DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht7 and chia.2

DIOPT Version :9

Sequence 1:	NP_647768.3	Gene:	Cht7 / 38370	FlyBaseID:	FBgn0035398	Length:	1013	Species:	Drosophila melanogaster
Sequence 2:	NP_998414.1	Gene:	chia.2 / 406338	ZFINID:	ZDB-GENE-040426-2014	Length:	470	Species:	Danio rerio

Alignment Length:	458	Identity:	196/458 - (42%)
Similarity:	270/458 - (58%)	Gaps:	30/458 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   562 CYLTSWSAKRPGAGKFQPENIDPKLCTHIVYAFATLQD-YKLTEATDDDPENYESVIALRDNNPD 625
            ||.|:||..|||.||:.|.|:||.||||:.||||.:.. .:|.....:|...|::...|::.||.
Zfish    25 CYFTNWSQYRPGIGKYTPANVDPFLCTHLFYAFAMINHANELITYEWNDETLYKAFNELKNTNPH 89

  Fly   626 LQILLAIGGWAFGSTPFKELTSNVFRMNQFVYEAIDFLRDYKFNGLDVDWEYP--RGA--EDRVA 686
            |:.|||:|||.||||.|..:.|:......|:..:|.|||.|.|:|:|:|||||  ||:  ||:..
Zfish    90 LRTLLAVGGWNFGSTQFSIMVSSAANRQTFIQSSIKFLRTYGFDGMDLDWEYPGSRGSPPEDKQR 154

  Fly   687 YVSLLKELRVAFEGEAKSSGLPRLLLTAAVPASFEAIAAGYDVPEISKYLDFINVMTYDFHGQWE 751
            :..|.|||..|:|.|.|::|..||:|:|||.|....|..||::.||:|||||||:|||||||.||
Zfish   155 FTLLCKELLEAYEAEGKATGRRRLMLSAAVSAGKGTIDDGYEIAEIAKYLDFINIMTYDFHGTWE 219

  Fly   752 RTVGHNSPLFALESATGYQKKLTVDYSAREWVKQGAPKEKLLIGMPTYGRSFELV-NDTQFDIGS 815
            |..||||||:......|.......||:.|.|...|.|.|||.:|..||||:|.|. :||  .:|:
Zfish   220 RFTGHNSPLYQGSKDEGDLVYFNTDYAMRYWRDNGTPVEKLRMGFATYGRTFRLTSSDT--SVGA 282

  Fly   816 PSSGGGKAGKFTNEAGFLSYYEVCSFLAADNTTLVWDSEQQVPFAYRGNQWVGFDDERSLKTKTE 880
            |:||...||.:|.||||.||||:|.||  :.||:.|..:|:||:|.:.::|||||.:.|.:||..
Zfish   283 PASGPASAGTYTREAGFWSYYEICGFL--EGTTVQWIDDQKVPYATKNSEWVGFDTKESYETKVR 345

  Fly   881 WLKEQGFGGIMVWSIDMDDFSGR-CGSGKYPLLTALNDELKDYKVELEYDGPYESHGPRGAYTTK 944
            :||::.|||..||::|:|||:|: ||.|.:||:..|.:.|   .:||....|..:..| |..||:
Zfish   346 YLKDKKFGGAFVWALDLDDFAGQFCGQGNHPLMGHLRNLL---DIELPPLPPPTTAKP-GQSTTR 406

  Fly   945 DPHDVT----------C-AEEDGHISYHKDWADCTHYYMCEGERKHHMPCPANLVFNPQENVCDW 998
            .....|          | .:.||..::    .|...||.|.|.:.:...|.|...|:.....|.|
Zfish   407 PTTTTTTTTHAPGPGFCNGKPDGLYAH----PDPNKYYSCAGGQTYVDNCGAGTEFDESCKCCGW 467

  Fly   999 PEN 1001
            |::
Zfish   468 PKH 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht7	NP_647768.3	Glyco_18	124..468	CDD:214753
		GH18_chitolectin_chitotriosidase	125..491	CDD:119351
		Glyco_18	559..898	CDD:214753	163/341 (48%)
		GH18_chitolectin_chitotriosidase	560..919	CDD:119351	173/363 (48%)
		CBM_14	951..1005	CDD:279884	14/52 (27%)
chia.2	NP_998414.1	GH18_chitolectin_chitotriosidase	23..385	CDD:119351	173/363 (48%)
		Glyco_18	24..363	CDD:214753	163/341 (48%)
		CBM_14	423..468	CDD:279884	12/48 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592086
Domainoid	1	1.000	352	1.000	Domainoid score	I965
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	1	1.000	-	-		mtm6443
orthoMCL	1	0.900	-	-		OOG6_100224
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.750