DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht7 and Cht10

DIOPT Version :9

Sequence 1:	NP_647768.3	Gene:	Cht7 / 38370	FlyBaseID:	FBgn0035398	Length:	1013	Species:	Drosophila melanogaster
Sequence 2:	NP_001036422.1	Gene:	Cht10 / 3355116	FlyBaseID:	FBgn0250907	Length:	2286	Species:	Drosophila melanogaster

Alignment Length:	976	Identity:	353/976 - (36%)
Similarity:	519/976 - (53%)	Gaps:	125/976 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 KVDDGTPKIVCYYTNWSQYRVKIGKFVPEDIPADLCTHIIFAFGWLKKNKLSSYESNDETKDNVP 181
            |..|...|::||:|||:.||..||:|.|:||..:||||:|:.|..|..::| ...::|...|...
  Fly   959 KPRDSHYKVICYFTNWAWYRKGIGRFTPDDINTELCTHVIYGFAVLDYSEL-VLRTHDSWADVEN 1022

  Fly   182 GLYERMMTLKKANPKLKILLALGGWSFGT-QKFKDMSSTRYTRQTFVYSAIPFLRKRGFDGLDMD 245
            ..|.|:.:||...  :|:.||||||:... .|:..:..:...|..||..|:.|:.|.||:|||:|
  Fly  1023 NFYTRVTSLKSKG--IKVSLALGGWNDSQGDKYSRLVRSPMARSRFVRHALEFIEKYGFEGLDLD 1085

  Fly   246 WEYP--------KGS-DDKKNFVLLLKELREAFEAEAQELKKPR-LLLSAAVPVGPDNIRGGYDV 300
            ||||        ||| ::|..|...::||.|||        :|| |:||.||......|..|||:
  Fly  1086 WEYPVCWQTECNKGSTEEKDGFTAWVQELSEAF--------RPRGLMLSTAVSPSRKIIDAGYDI 1142

  Fly   301 PAIASYLDFINLMAYDFHGKWERETGHNAPLY-APSTDSEWRKQLSVDNAASLWVKMGAPKEKLV 364
            |.::.|.|:|.:|.|||||.|:::|||.|||| .|..|.|:   .:|:.:.:.|::.|||.:|||
  Fly  1143 PQLSRYFDWIAVMTYDFHGHWDKKTGHVAPLYHHPDDDFEY---FNVNYSINYWMEKGAPSQKLV 1204

  Fly   365 IGMPTYGRSFTLANPDKHGPNAPASGGGREGVYTKEGGFLAYYEICEMLLNGAVYVWDDEM--KV 427
            :|:|.||:||||.|.:..|.||.|...|..|.:|:..||||||||||.:......|..||.  ..
  Fly  1205 MGIPLYGQSFTLENTNSSGLNAKAPAPGEAGEFTRAAGFLAYYEICERVNRQGWQVVHDEFGRMG 1269

  Fly   428 PYLVDGDQWVGFDDERAIRNKMHWIKSNGFGGAMVWTIDMDDFKGEVCGGNVKYPLIGAMRE--- 489
            ||...|.|||.:|....:|.|...::|...||.|||.:|:||||.. ||..| :||:..:..
  Fly  1270 PYAYKGTQWVSYDSPDMVRKKSLLVRSLKLGGGMVWALDLDDFKNR-CGNGV-HPLLTEIHNVLK 1332

  Fly   490 ---ELLGISRGKEAKDVNWTAVAATFEDIEEK----PE--PIKISVDEILNKVRKPQ-------V 538
               .|:.|....|.....:..:.   |:|.|.    ||  ||:..:....|:..:.:       |
  Fly  1333 DPPSLMEIPGPIETTPTEYPGME---EEIHESNGEGPEVQPIEAVMQTCENEGEEHEGILDPNHV 1394

  Fly   539 QKKQRIKSGANAVASNTRPAQVFCYLTSWSAKRPGAGKFQPENIDPKLCTHIVYAFATLQDYKLT 603
            .:::.|:  |..:|:..:   :.||.|:|:..|.|.|||.||:||..|||||:|.||.|....||
  Fly  1395 LEEENIE--ATEMATEFK---IICYFTNWAWYRQGGGKFLPEDIDSDLCTHIIYGFAVLSRDNLT 1454

  Fly   604 EATDD-----DPENYESVIALRDNNPDLQILLAIGGW-AFGSTPFKELTSNVFRMNQFVYEAIDF 662
            ....|     |.:.||.::|.|...  .::.:||||| ......:..|..|....::|:...:||
  Fly  1455 IQPHDSWADLDNKFYERIVAYRKKG--AKVTVAIGGWNDSAGDKYSRLVRNPEARSRFIRNVLDF 1517

  Fly   663 LRDYKFNGLDVDWEYP--------RG-AEDRVAYVSLLKELRVAFEGEAKSSGLPR-LLLTAAVP 717
            :.:|.|:|||:|||||        :| ||:::.:.:|::||..||:        || |:|:|||.
  Fly  1518 IEEYNFDGLDLDWEYPVCWQVDCKKGTAEEKIGFSALVRELFYAFQ--------PRGLILSAAVS 1574

  Fly   718 ASFEAIAAGYDVPEISKYLDFINVMTYDFHGQWERTVGHNSPLFALESATGYQKKLTVDYSAREW 782
            .:.:.|.|||:|.|:|.|..:|:||.||:||||::..||.:|:::....|.   ....::|...|
  Fly  1575 PNKKVIDAGYEVAELSHYFSWISVMAYDYHGQWDKKTGHVAPMYSHPEGTA---NFNANFSMNYW 1636

  Fly   783 VKQGAPKEKLLIGMPTYGRSFELVNDTQFDIGSPSSGGGKAGKFTNEAGFLSYYEVCSFLAADNT 847
            :..||.:.||::|:|.||:||.|...|:..:.:|:.|||:||:.|...|||:|||:|..:.....
  Fly  1637 ISMGADRRKLVMGIPLYGQSFSLAETTKHQLNAPTYGGGEAGEATRARGFLAYYEICLKIRHHRW 1701

  Fly   848 TLVWDSEQQV-PFAYRGNQWVGFDDERSLKTKTEWLKEQGFGGIMVWSIDMDDFSGRCGSGKYPL 911
            .:|.|::.:: ||||.|:|||.|||...::.|:|::|..|.||.|:|::|:|||...|....|||
  Fly  1702 NVVRDTKGRIGPFAYHGDQWVSFDDVPMIRHKSEYIKAMGLGGAMIWALDLDDFKNVCECESYPL 1766

  Fly   912 LTALNDELKDY-----KVELEYDGPYESHGPRGAYTTKDPHDVTCAEEDG--------------- 956
            |.|:|..|:.:     |..||  .|..:..|    ..|.|...|.....|
  Fly  1767 LKAINRVLRGFGGPQPKCLLE--NPKSTMKP----NIKPPFRPTINAPSGPNLDSPTQNVSLNVL 1825

  Fly   957 HISYHK------DWADCTHYYMCEGERKHHMPCPANLVFNPQENVCDWPENVE---GCHTPTEAP 1012
            .|..|.      :| |||.||:||........||..|.:|  :..||||.||:   |.:..|:.|
  Fly  1826 SIKCHSKNYLAHEW-DCTKYYICEHGTYVERSCPLGLQWN--KTYCDWPTNVQSSLGSNQRTQEP 1887

  Fly  1013 A 1013
            |
  Fly  1888 A 1888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht7	NP_647768.3	Glyco_18	124..468	CDD:214753	147/357 (41%)
		GH18_chitolectin_chitotriosidase	125..491	CDD:119351	155/385 (40%)
		Glyco_18	559..898	CDD:214753	136/355 (38%)
		GH18_chitolectin_chitotriosidase	560..919	CDD:119351	146/375 (39%)
		CBM_14	951..1005	CDD:279884	21/77 (27%)
Cht10	NP_001036422.1	Glyco_18	220..565	CDD:214753
		GH18_chitolectin_chitotriosidase	221..586	CDD:119351
		ChtBD2	697..737	CDD:214696
		CBM_14	801..848	CDD:279884
		CBM_14	875..918	CDD:279884
		Glyco_18	966..1310	CDD:214753	147/357 (41%)
		GH18_chitolectin_chitotriosidase	967..1331	CDD:119351	155/379 (41%)
		Glyco_18	1410..1753	CDD:214753	136/358 (38%)
		GH18_chitolectin_chitotriosidase	1411..1774	CDD:119351	146/375 (39%)
		ChtBD2	1834..1871	CDD:214696	14/39 (36%)
		Glyco_18	1909..2253	CDD:214753
		GH18_chitolectin_chitotriosidase	1910..2274	CDD:119351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463783
Domainoid	1	1.000	188	1.000	Domainoid score	I962
eggNOG	1	0.900	-	-		E1_COG3325
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12932at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6443
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850