DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht7 and cht-1

DIOPT Version :9

Sequence 1:	NP_647768.3	Gene:	Cht7 / 38370	FlyBaseID:	FBgn0035398	Length:	1013	Species:	Drosophila melanogaster
Sequence 2:	NP_508588.1	Gene:	cht-1 / 180628	WormBaseID:	WBGene00000503	Length:	617	Species:	Caenorhabditis elegans

Alignment Length:	407	Identity:	182/407 - (44%)
Similarity:	250/407 - (61%)	Gaps:	8/407 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 GAAVAAGGTALVASGSSLKGKKTKVDDGTPKIV--CYYTNWSQYRVKIGKFVPEDIPADLCTHII 156
            ||.:......:||:.:.:..:.....:.|...:  ||:|||:|||....||||||....|||||:
Worm    22 GATIRNHPADVVAARNKITSRSVARSEPTNSYIRPCYFTNWAQYRQGRAKFVPEDYTPGLCTHIL 86

  Fly   157 FAFGWLKKN-KLSSYESNDETKDNV-PGLYERMMTLKKANPKLKILLALGGWSFGTQKFKDMSST 219
            |||||:..: .:.:|:..|...|.. .|:|.|:..||..:.:||.||:.|||||||..|:.|:::
Worm    87 FAFGWMNADYTVRAYDPADLPNDWAGEGMYRRVNKLKVTDTQLKTLLSFGGWSFGTALFQGMAAS 151

  Fly   220 RYTRQTFVYSAIPFLRKRGFDGLDMDWEYPKGSDDKKNFVLLLKELREAFEAEAQELKKPRLLLS 284
            ..:|:.|:.|||.|:|..||||:|:|||||.|:.|..|:|.|:|||:.|.|:||....|.|||::
Worm   152 SASRKVFIDSAITFVRTWGFDGIDIDWEYPSGATDMANYVALVKELKAACESEAGSTGKDRLLVT 216

  Fly   285 AAVPVGPDNIRGGYDVPAIASYLDFINLMAYDFHGKWERETGHNAPLYAPS-TDSEWRKQLSVDN 348
            |||..||..|..|||:|.:|...|||.||:|||.|.|....|.|:||||.: ..:|| ...:||:
Worm   217 AAVAAGPATIDAGYDIPNLAPNFDFILLMSYDFFGAWASLVGFNSPLYATTELPAEW-NGWNVDS 280

  Fly   349 AASLWVKMGAPKEKLVIGMPTYGRSFTLANPDKHGPNAPASGGGREGVYTKEGGFLAYYEICEML 413
            :|..|.:.|.||||:::|||||||.:||.|.....|....| ..:...|.:|.|..||:|.||||
Worm   281 SARYWNQKGMPKEKIIVGMPTYGRGWTLNNASAINPGTSGS-PAKITQYVQEAGVGAYFEFCEML 344

  Fly   414 LNGAVYVWDDEMKVPYLVDGDQWVGFDDERAIRNKMHWIKSNGFGGAMVWTIDMDDFKGEVCGGN 478
            .|||...||.:.:|||||.|:||..:|||.:..|||.::|..|:|||.|||:|.|||.......|
Worm   345 ANGATRYWDSQSQVPYLVQGNQWWSYDDEESFANKMAYVKREGYGGAFVWTLDFDDFNAGCSNSN 409

  Fly   479 VK-YPLIGAMREELLGI 494
            .: ||||..:.:||.|:
Worm   410 GQLYPLISVIAKELGGV 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht7	NP_647768.3	Glyco_18	124..468	CDD:214753	166/348 (48%)
		GH18_chitolectin_chitotriosidase	125..491	CDD:119351	174/371 (47%)
		Glyco_18	559..898	CDD:214753
		GH18_chitolectin_chitotriosidase	560..919	CDD:119351
		CBM_14	951..1005	CDD:279884
cht-1	NP_508588.1	GH18_chitolectin_chitotriosidase	55..423	CDD:119351	174/369 (47%)
		Glyco_18	57..399	CDD:214753	166/343 (48%)
		CBM_14	481..532	CDD:279884
		CBM_14	567..615	CDD:279884
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167339
Domainoid	1	1.000	337	1.000	Domainoid score	I589
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68318
Inparanoid	1	1.050	382	1.000	Inparanoid score	I1186
Isobase	1	0.950	-	0	Normalized mean entropy	S2365
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	1	1.000	-	-		otm14141
orthoMCL	1	0.900	-	-		OOG6_100224
Panther	1	1.100	-	-	O	PTHR11177
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2066
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.780