DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht7 and lmd-4

DIOPT Version :9

Sequence 1:	NP_647768.3	Gene:	Cht7 / 38370	FlyBaseID:	FBgn0035398	Length:	1013	Species:	Drosophila melanogaster
Sequence 2:	NP_504862.2	Gene:	lmd-4 / 179121	WormBaseID:	WBGene00017233	Length:	2011	Species:	Caenorhabditis elegans

Alignment Length:	959	Identity:	216/959 - (22%)
Similarity:	354/959 - (36%)	Gaps:	321/959 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 IPADLCT-HIIFAFGWLKKNKL-SSYESNDETK---DNVPG---LYER----MMTLKKANPKLKI 199
            :.||:|. .:.||    |...| .:.:.||.||   ::|||   |.:|    :::|.....||..
Worm  1162 VEADICVPSVTFA----KDTVLYCAKDKNDCTKKENEDVPGLKYLADRKLGGVISLCAVGSKLAK 1222

  Fly   200 LLALGGWS----------FG----------------------TQK-----FKDM------SSTRY 221
            ||..||.|          ||                      |.|     |.||      ....|
Worm  1223 LLTKGGLSLCWEILAADYFGFIGKLDLSSNLRLVVVDVEGGATMKVHGLAFPDMCEHSEFQCEDY 1287

  Fly   222 TR---------QTFVYSAIPFLRKRGFDG---LDMDWEYPK--GSDDKKNFVLLLKELREAFEAE 272
            .|         :.:.|.....|:..||.|   |:..::.|.  |.|:.|...::|:..|...:..
Worm  1288 CRWRADEWDNGKAYGYLKFKALKVFGFSGFKLLEESFDEPSRVGCDEGKEAAVVLRNTRTCKDQA 1352

  Fly   273 AQELKKPRLLLSAAVPVGPDNIRGGYDVPAIASYLDFINLMAYDFHGKWERETGHNAPLYAPSTD 337
            .:|::  |...|.      |::.|                        |::            .|
Worm  1353 EREIQ--RRCWSG------DDMMG------------------------WDK------------LD 1373

  Fly   338 SEWRKQLSVDNAASLWVKMGAPKEKLVIGMPTYGRS-FTLANPDKHGPNAPASGGGREGVYTKEG 401
            .||                     ........:||: |.....|||
Worm  1374 KEW---------------------SFAFQPHIFGRTLFVCEFTDKH------------------- 1398

  Fly   402 GFLAYYEICEMLLNGAVYVWDDEMKVPYLVDGDQWVGFDDERAIRNKMHWIKSNGFGGAMVWTID 466
                                            :|.:|||        ::..||:..|.|..:.:.
Worm  1399 --------------------------------NQKIGFD--------VYGGKSDNKGKATFYYVV 1423

  Fly   467 MDDFKGEVCGGNVKYPLIGAMREELLGISRGKEAKDVNWTAVAATFEDIEEKPEPIKISVDEILN 531
            .:|   .:..|..||     ..::|:|          :|.....     |:||||.|...    :
Worm  1424 KND---GIYFGTEKY-----KEDKLMG----------SWDNKCE-----EDKPEPPKPDP----S 1461

  Fly   532 KVRKPQVQKKQRIKSGANAVASNTRPAQVFCYLTSWSAKRPGAGKFQPENIDPKLCTHIVYAFAT 596
            ||.:|         :|.:::.:.:...::..|.|.|..:.      ..||...|| ||:::||..
Worm  1462 KVEEP---------TGKSSLPAASCGKRIVGYYTGWGDRE------ITENQLKKL-THVIFAFVA 1510

  Fly   597 LQD---YKLTEATDDD--PE----------NYESVIALRDNNPDLQILLAIGGWAFGSTPFKELT 646
            :.:   .|....::||  |:          |.:.  ..|..|..:::|.|:|||. .|..|..:.
Worm  1511 MYEDGSVKFGAVSEDDSGPQAAKKAERRFLNMKK--KARAANSGVRVLFAVGGWD-NSQYFSSVA 1572

  Fly   647 SNVFRMNQFVYEAIDFLRDYKFNGLDVDWEYP-RGAEDRVAYVSLLKELRVAFEGEAKSSGL--P 708
            ::..:..:||.....|:.|.|.:|:|:||||| ...:|...:|.|:||:|..|...||....  |
Worm  1573 ADSGKRKKFVDSIASFVEDQKIDGVDLDWEYPDSNGKDAKNHVQLIKEIREKFSEMAKKKKRKDP 1637

  Fly   709 RLLLTAAVPASFEAIAAGYDVPEISKYLDFINVMTYDFHGQWERT----VGHNSPLFALESATGY 769
            .::..|:....:. :..|||:..|.||.|||||||||::|.||..    .|..:||: ..|..|:
Worm  1638 YVITLASAAGEWN-LRKGYDLKGILKYADFINVMTYDYYGAWESKWGAYTGTPAPLY-FGSLKGF 1700

  Fly   770 QKKLTVDYSAREWVKQGAPKEKLLIGMPTYGRSFELV------NDTQFDIGSPSSGGGKAGKFTN 828
            ..||..|:|.:.:..:.....:|.:|:|.|||.::.|      :|..:...:|.:     ||:
Worm  1701 SGKLNADFSMKFYACKTEKPSQLNMGVPFYGRYWKNVLGPIDKSDNMWRTAAPQN-----GKY-- 1758

  Fly   829 EAGFLSYYEVCSFLAAD---NTTLVWDSEQQVPFAYR--GNQWVGFDDERSLKTKTEWLKEQGFG 888
            |.|::.:..    ||.:   ..:..|..:.:.|:...  ..:::||::|||||.|.::..::..|
Worm  1759 EGGYVGWRN----LAKEGWNKGSASWHEKTKTPYIMNNGAKKFLGFENERSLKEKMKYATDRNLG 1819

  Fly   889 GIMVWSIDMDD----------FSGRCGSGKYPLLT----ALND------ELKDYKVELEYDGPYE 933
            |:|:|::|:||          .:|.|..||...:|    .::|      |..|.|.:    |...
Worm  1820 GLMIWALDLDDDADTLLNLVSSAGLCSGGKGDKVTYKCVPIDDVRWWTPENSDEKKQ----GQCG 1880

  Fly   934 SHGP--RGAYTTKDPHD--VTCAEEDGHISYHKDWADCTHYYMCEGERK 978
            ...|  .|.|...||.|  .:|....|:....|::.||..   |...||
Worm  1881 KSAPLINGFYPVCDPDDPGFSCCGAAGYCGSGKEYCDCKG---CVNYRK 1926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht7	NP_647768.3	Glyco_18	124..468	CDD:214753	68/390 (17%)
		GH18_chitolectin_chitotriosidase	125..491	CDD:119351	72/413 (17%)
		Glyco_18	559..898	CDD:214753	105/371 (28%)
		GH18_chitolectin_chitotriosidase	560..919	CDD:119351	113/411 (27%)
		CBM_14	951..1005	CDD:279884	8/28 (29%)
lmd-4	NP_504862.2	LysM	25..65	CDD:197609
		LysM	79..120	CDD:197609
		LysM	142..185	CDD:197609
		LysM	209..250	CDD:197609
		LysM	270..313	CDD:197609
		LysM	334..377	CDD:197609
		LysM	401..444	CDD:197609
		LysM	469..509	CDD:197609
		LysM	550..590	CDD:197609
		LysM	635..678	CDD:197609
		LysM	710..750	CDD:197609
		LysM	760..802	CDD:197609
		LysM	876..919	CDD:197609
		Self-incomp_S1	1359..1433	CDD:283566	23/198 (12%)
		Glyco_18	1480..1825	CDD:214753	103/367 (28%)
		GH18_chitinase-like	1481..1824	CDD:299167	103/365 (28%)
		ChtBD1_GH18_2	1873..1924	CDD:211315	14/57 (25%)
		ChtBD1_GH18_2	1951..2002	CDD:211315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14141
orthoMCL	1	0.900	-	-		OOG6_100224
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710