DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAN3 and Pan3

DIOPT Version :9

Sequence 1:	NP_647767.1	Gene:	PAN3 / 38369	FlyBaseID:	FBgn0035397	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	XP_006248904.1	Gene:	Pan3 / 360760	RGDID:	1590880	Length:	887	Species:	Rattus norvegicus

Alignment Length:	815	Identity:	322/815 - (39%)
Similarity:	452/815 - (55%)	Gaps:	123/815 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SDTAAMDPIF---FSPTNGI--PSESKLATYMNRQNVATPSGYGLN--------------NGFSL 58
            :||:..|..|   |...||.  |.|:|. ..|.|...::.|...||              :..||
  Rat   149 TDTSLTDSYFSTSFIGVNGFGSPVETKY-PLMQRMTSSSSSPSLLNDSAKPYTGHDPLTSSASSL 212

  Fly    59 LNLDSPLNKKSQVTPQSPEFIPTRLGSTPNFYAPYHNAPMQLSNGLNGVNGLTAAAAAAAAAAAA 123
            .|....||...:..|:.     .|||.......|..:...:..|.:             ...|..
  Rat   213 FNDFGALNISQRRKPRK-----YRLGMLEERLVPMGSKARKAKNPI-------------GCLADR 259

  Fly   124 AAAAVPSSTSSASSASVTISKTANGGASMLALQKTASIASVTIAQQQPQHPQKQQQHPPSVG--- 185
            ..:.||.:....:..:....:|.|..||.. :.|..|.:.::...|.......|....||:|
  Rat   260 CKSGVPINMVWWNRVTENNLQTPNPTASEF-IPKGGSTSRLSNVSQSNMSAFSQVFSHPSMGSPA 323

  Fly   186 ------GGAVSAASAPIAISGAPPNPAAAPFVSSMSAQTPLKGRGAMMRQESPTAAMISGAGPGE 244
                  |.::||.|:|:......|:.:.||   ...:.||           :|.:.|:
  Rat   324 TAGLAPGMSLSAGSSPLHSPKITPHTSPAP---RRRSHTP-----------NPASFMV------- 367

  Fly   245 KSPPHGMTPHGASPIPSALPTS---VHQENVGGTIYFYPTANAQNSQPVVNSMVVDGTHPALHGV 306
              ||...|| ..:|:|.. |:|   :.:|.||||.|||                .|.|...|.|:
  Rat   368 --PPSASTP-ANNPVPQT-PSSGQVIQKETVGGTTYFY----------------TDTTPAPLTGM 412

  Fly   307 SAVAPMSAGVPAAMMYTGHVYPGPSSNVVTMQPKTLLESAFFMPDEMRAEVLARNEISNLIMDAA 371
              |.|           ..|:||..:.:|..||||....| |||.||:|.|::.|:.|:...:|.|
  Rat   413 --VFP-----------NYHIYPPTAPHVAYMQPKANAPS-FFMADELRQELINRHLITMAQIDQA 463

  Fly   372 EAAQHALPLEVENYHALYPLE--PPAQPLHAKLTFPATT--YRATHNTTGYKYCLRRIHGFRLQS 432
            :..  |:|.||::||:|:|||  ||...:.....|...|  |:|.::.....|||||||||||.:
  Rat   464 DLP--AVPTEVDSYHSLFPLEPLPPPNRIQKSSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVN 526

  Fly   433 TKCMTLVEMWKKLQHTNVVQLREVFTTKAFGDNSLVLVYDYHPGSQTLLAKYFTPAPETNGY-TD 496
            ||||.||:||||:||:|:|.||||||||||.:.|||..||:|.|.:|:::::|.. |.::.| |.
  Rat   527 TKCMVLVDMWKKIQHSNIVTLREVFTTKAFSEPSLVFAYDFHAGGETMMSRHFND-PNSDAYFTK 590

  Fly   497 PFQGEARPFSHKSNMQRTSNGPLLPEATIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGK-R 560
            ...|:     |...:.|...| ||||:.||:.|:||::.|:.||.|||||:|:|||||::|.| |
  Rat   591 RKWGQ-----HDGPLPRQHAG-LLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILITSKTR 649

  Fly   561 VRFSSCCISDITQFDPNA-SNPLALVNMHQQDDLTALGRLVLALACRCLQSVQRDNVQSSIDMVT 624
            :|.:...:.|:..||.:. :|||||:..:||.||.:||::||||||..|..:||:|:|.::::||
  Rat   650 LRVNCVGVFDVLTFDNSQNNNPLALMAQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVT 714

  Fly   625 RNYSTDLRNFIVYLFTTNNR-RSVTDLMPMIGARFYTQLDALQSKIDMQEDELAKEMENGRLYRI 688
            .|||:||:|.|:||.|..|| |||.|:||||||||||||||.|.:.|:.|::||||::||||:|:
  Rat   715 INYSSDLKNLILYLLTDQNRMRSVNDIMPMIGARFYTQLDAAQMRNDVIEEDLAKEVQNGRLFRL 779

  Fly   689 LVKLNSINERPDFNLDCTWSETGDRYMLKLFRDYLFHSVTEDGRPWLDHAHIVQCLNKLDAGSIE 753
            |.||.:|||||:|..|.|||||||||:||||||:|||.|||.|.||:|.:||:.||||||||..|
  Rat   780 LAKLGTINERPEFQKDPTWSETGDRYLLKLFRDHLFHQVTEAGAPWIDLSHIISCLNKLDAGVPE 844

  Fly   754 RVQLMSRDEQSVLIVSYAELKNCLENAFSELMSSA 788
            ::.|.||||:|||:|:|::||.|.||.|.||:::|
  Rat   845 KISLTSRDEKSVLVVTYSDLKRCFENTFQELIAAA 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN3	NP_647767.1	DUF4797	245..284	CDD:292670	16/41 (39%)
PAN3	NP_647767.1	PKc	406..>570	CDD:270622	81/167 (49%)
Pan3	XP_006248904.1	zf-CCCH	51..70	CDD:279036
		PKc_like	489..>657	CDD:304357	82/174 (47%)
		PKc_like	<606..729	CDD:304357	63/123 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348887
Domainoid	1	1.000	280	1.000	Domainoid score	I1602
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1351
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1515085at2759
OrthoFinder	1	1.000	-	-		FOG0003944
OrthoInspector	1	1.000	-	-		oto98435
orthoMCL	1	0.900	-	-		OOG6_103887
Panther	1	1.100	-	-	LDO	PTHR12272
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3243
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900