DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAN3 and PAN3

DIOPT Version :9

Sequence 1:	NP_647767.1	Gene:	PAN3 / 38369	FlyBaseID:	FBgn0035397	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	NP_787050.6	Gene:	PAN3 / 255967	HGNCID:	29991	Length:	887	Species:	Homo sapiens

Alignment Length:	779	Identity:	318/779 - (40%)
Similarity:	443/779 - (56%)	Gaps:	149/779 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 SNGLNGVNGLTAAAAAAAAAAAAAAAAVPSSTSSASSASVTISKTANGGASMLALQKTAS----- 160
            |....||||.       .:........:...|:|:||.|: ::.:|...::...|...||
Human   163 STSFIGVNGF-------GSPVETKYPLMQRMTNSSSSPSL-LNDSAKPYSAHDPLTSPASSLFND 219

  Fly   161 IASVTIAQQQPQHPQK------QQQHPPSVGGGAVSAASAPIAI------SGAP----------- 202
            ..::.|:|:  :.|:|      :::..|.  |.....|..||..      ||.|
Human   220 FGALNISQR--RKPRKYRLGMLEERLVPM--GSKARKAKNPIGCLADRCKSGVPINMVWWNRVTE 280

  Fly   203 -----PNPAAAPFV--------------SSMSAQTPLKGRGAMMRQESPTAAMISGAGPG----- 243
                 |||.|:.|:              |:|||.:.:....:|   .||..|   |..||
Human   281 NNLQTPNPTASEFIPKGGSTSRLSNVSQSNMSAFSQVFSHPSM---GSPATA---GLAPGMSLSA 339

  Fly   244 EKSPPHG--MTPHGASP---------------IPSALPTSVH--------------QENVGGTIY 277
            ..||.|.  :||| .||               :||:..|||:              :|.||||.|
Human   340 GSSPLHSPKITPH-TSPAPRRRSHTPNPASYMVPSSASTSVNNPVSQTPSSGQVIQKETVGGTTY 403

  Fly   278 FYPTANAQNSQPVVNSMVVDGTHPALHGVSAVAPMSAGVPAAMMYTGHVYPGPSSNVVTMQPKTL 342
            ||                .|.|...|.|:  |.|           ..|:||..:.:|..||||..
Human   404 FY----------------TDTTPAPLTGM--VFP-----------NYHIYPPTAPHVAYMQPKAN 439

  Fly   343 LESAFFMPDEMRAEVLARNEISNLIMDAAEAAQHALPLEVENYHALYPLE--PPAQPLHAKLTFP 405
            ..| |||.||:|.|::.|:.|:...:|.|:  ..|:|.||::||:|:|||  ||...:.....|.
Human   440 APS-FFMADELRQELINRHLITMAQIDQAD--MPAVPTEVDSYHSLFPLEPLPPPNRIQKSSNFG 501

  Fly   406 ATT--YRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGDNSLV 468
            ..|  |:|.::.....|||||||||||.:||||.||:||||:||:|:|.||||||||||.:.|||
Human   502 YITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTKAFAEPSLV 566

  Fly   469 LVYDYHPGSQTLLAKYFTPAPETNGY-TDPFQGEARPFSHKSNMQRTSNGPLLPEATIWSIIMQL 532
            ..||:|.|.:|:::::|.. |..:.| |....|:     |:..:.|...| ||||:.||:.|:||
Human   567 FAYDFHAGGETMMSRHFND-PNADAYFTKRKWGQ-----HEGPLPRQHAG-LLPESLIWAYIVQL 624

  Fly   533 TAGLKAIHHAGLACKVLDPTKIIVTGK-RVRFSSCCISDITQFDPNA-SNPLALVNMHQQDDLTA 595
            ::.|:.||.|||||:|:|||||::||| |:|.:...:.|:..||.:. :|||||:..:||.||.:
Human   625 SSALRTIHTAGLACRVMDPTKILITGKTRLRVNCVGVFDVLTFDNSQNNNPLALMAQYQQADLIS 689

  Fly   596 LGRLVLALACRCLQSVQRDNVQSSIDMVTRNYSTDLRNFIVYLFTTNNR-RSVTDLMPMIGARFY 659
            ||::||||||..|..:||:|:|.::::||.|||:||:|.|:||.|..|| |||.|:|||||||||
Human   690 LGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNRMRSVNDIMPMIGARFY 754

  Fly   660 TQLDALQSKIDMQEDELAKEMENGRLYRILVKLNSINERPDFNLDCTWSETGDRYMLKLFRDYLF 724
            |||||.|.:.|:.|::||||::||||:|:|.||.:|||||:|..|.|||||||||:||||||:||
Human   755 TQLDAAQMRNDVIEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTWSETGDRYLLKLFRDHLF 819

  Fly   725 HSVTEDGRPWLDHAHIVQCLNKLDAGSIERVQLMSRDEQSVLIVSYAELKNCLENAFSELMSSA 788
            |.|||.|.||:|.:||:.||||||||..|::.|:||||:|||:|:|::||.|.||.|.||:::|
Human   820 HQVTEAGAPWIDLSHIISCLNKLDAGVPEKISLISRDEKSVLVVTYSDLKRCFENTFQELIAAA 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN3	NP_647767.1	DUF4797	245..284	CDD:292670	21/69 (30%)
PAN3	NP_647767.1	PKc	406..>570	CDD:270622	82/167 (49%)
PAN3	NP_787050.6	zf-CCCH	49..68	CDD:279036
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..147
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..307		7/27 (26%)
		PABPC-interacting motif-2 (PAM-2). /evidence=ECO:0000255\|HAMAP-Rule:MF_03181, ECO:0000269\|PubMed:17595167	284..299		4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	325..392		20/80 (25%)
		Pseudokinase domain. /evidence=ECO:0000255\|HAMAP-Rule:MF_03181	463..750		151/292 (52%)
		PKc_like	493..>661	CDD:304357	82/170 (48%)
		PKc_like	<610..733	CDD:304357	69/125 (55%)
		Knob domain. /evidence=ECO:0000255\|HAMAP-Rule:MF_03181	790..887		36/61 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155012
Domainoid	1	1.000	202	1.000	Domainoid score	I3004
eggNOG	1	0.900	-	-		E1_KOG3741
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1414
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1515085at2759
OrthoFinder	1	1.000	-	-		FOG0003944
OrthoInspector	1	1.000	-	-		oto91353
orthoMCL	1	0.900	-	-		OOG6_103887
Panther	1	1.100	-	-	LDO	PTHR12272
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2218
SonicParanoid	1	1.000	-	-		X3243
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790