DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PAN3 and SPAC1B1.04c

DIOPT Version :9

Sequence 1:	NP_647767.1	Gene:	PAN3 / 38369	FlyBaseID:	FBgn0035397	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	NP_594234.2	Gene:	SPAC1B1.04c / 2542552	PomBaseID:	SPAC1B1.04c	Length:	681	Species:	Schizosaccharomyces pombe

Alignment Length:	822	Identity:	203/822 - (24%)
Similarity:	335/822 - (40%)	Gaps:	231/822 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 FFSPTN--GIPSESK--LATYMNRQNVATPSGYGLNNGFSL-LNLDSP------LNKKSQVTPQS 75
            ||...|  ..|:.||  .||.::.|          |:|||. |:::||      |:|.|..:..:
pombe    32 FFQHKNQDNAPASSKPPSATAIDPQ----------NSGFSTKLSINSPSFTPLKLSKTSISSASN 86

  Fly    76 PEFIP-TRLGSTPNFYAPYHNAPMQLSNGLNG------------VNGLTAAAAAAAA------AA 121
            .|.:| ||    |..|:      ..||:|.||            |:.:|:::.||.|      :.
pombe    87 KESVPLTR----PKSYS------SALSSGKNGAAAQQAANSPKTVSLMTSSSKAANALQTHKSSL 141

  Fly   122 AAAAAAVPSSTSSASSASVTISKTANGGASMLALQKTASIASVTIAQQQPQHPQKQQQHPPSVGG 186
            |.||:|||.|.|.|::.|:..|      ||:.:|....|::::.
pombe   142 ARAASAVPFSPSKATTVSLKES------ASLTSLSNNKSVSNLN--------------------- 179

  Fly   187 GAVSAASAPIAISGAPPNPAAAPFVSSMSAQTPLKGRGAMMRQESPTAAMISGAGPGEKSPPHGM 251
                      :||||                            .||:.::::         .|.:
pombe   180 ----------SISGA----------------------------SSPSGSLVN---------LHSL 197

  Fly   252 TPHGASPIPSALPTSVHQENVGGTIYFYPTANAQNSQPVVNSMVVDGTHPALHGVSAVAPMSAGV 316
            | ..||                    |.|..:..||..:.|                 |.||..:
pombe   198 T-RSAS--------------------FVPQPSVPNSGQLSN-----------------ADMSRHI 224

  Fly   317 PAAMMYTGHVYPGPSSNVVTMQPKTLLESAFFMPDEMRAEVLARNEISNLIMDAAEAAQHA---- 377
            .|.       :|....|:...|.||   ::||:.|:         .:........|..|.|
pombe   225 LAR-------FPPFFHNLNEQQQKT---TSFFLADD---------HLKWFTYLTQEFYQFANIPK 270

  Fly   378 LPLEVENYHALYPLEPPAQPLHAKLTFPATTYRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMW 442
            ||..|.:||:|.|.......|.. |.:..:.|:......|..|...::..|.|.:.:.:|.|..|
pombe   271 LPSHVLSYHSLIPRRMIVTVLPV-LRYATSIYKVIDGNNGLPYSFVQLRDFTLLNDRNITNVSPW 334

  Fly   443 KKLQHTNVVQLREVFTTKAFGDNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSH 507
            .|:...:|:::||.|||.||...|:|.||:|.|...:|...:|                |.|...
pombe   335 TKVDSPHVIKIREAFTTHAFEQKSIVFVYNYLPSCPSLYDLFF----------------ASPVFR 383

  Fly   508 KSNMQRTSNGPLLPEAT---IWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGK-RVRFSSCCI 568
            |.......:.||  :||   :|....||.:.|.:||.:|||.|::....:::.|| |:......|
pombe   384 KRTSSFYFSQPL--KATKEVLWCFASQLISALYSIHSSGLAAKMVSLKNVLMVGKMRLAIFGLGI 446

  Fly   569 SDITQFDPNASNPLALVNMHQQDDLTALGRLVLALACRCLQSVQRDNVQSSIDMVTRNYSTDLRN 633
            .|:.|  ..::.||..:   |::|...:|.::||||.. .::|.....::.:..:....|||...
pombe   447 MDVIQ--EESTEPLTSL---QRNDCRDVGLILLALATD-TENVTLSTAKAHLTRLKTIVSTDASL 505

  Fly   634 F-IVYLFTTNNRRSVTDLMPMIGARFYTQLDALQSKIDMQEDELAKEMENGRLYRILVKLNSINE 697
            . ::.:...|....:..|:|.:.:......:::....|:.|..||:::||.||.|:|:||..:::
pombe   506 VELIEVLIFNEELRIQTLLPTMLSYMVNNYESVLLMEDVYETYLAEQVENDRLLRLLLKLEFLDD 570

  Fly   698 RPDFNLDCTWSETGDRYMLKLFRDYLF--------------HSVTEDGRPWLDHAHIVQCLNKLD 748
            ||::..|..||.:|..::::|||.|:|              .|.|...|..|:.||::.||||||
pombe   571 RPEYVDDPDWSASGVYFVIRLFRKYMFQVQTIDDASKKPTLQSTTTPPRKLLNKAHLLSCLNKLD 635

  Fly   749 AGSIERVQLMSRDEQSVLIVSYAELKNCLENAFSELMSSAAN 790
            ||:.|  |::..||.:.:|:|:.|:|..:..||.||....:|
pombe   636 AGTDE--QILLEDEFTRIIMSFKEVKTTINTAFMELERRCSN 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN3	NP_647767.1	DUF4797	245..284	CDD:292670	6/38 (16%)
PAN3	NP_647767.1	PKc	406..>570	CDD:270622	46/167 (28%)
SPAC1B1.04c	NP_594234.2	PKc	299..>456	CDD:270622	48/176 (27%)
SPAC1B1.04c	NP_594234.2	PKc_like	<405..510	CDD:304357	28/110 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	90	1.000	Domainoid score	I2079
eggNOG	1	0.900	-	-		E1_KOG3741
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I1221
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003944
OrthoInspector	1	1.000	-	-		oto101952
orthoMCL	1	0.900	-	-		OOG6_103887
Panther	1	1.100	-	-	O	PTHR12272
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2218
SonicParanoid	1	1.000	-	-		X3243
TreeFam	1	0.960	-	-
	11	10.850