DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAN3 and panl-3

DIOPT Version :9

Sequence 1:	NP_647767.1	Gene:	PAN3 / 38369	FlyBaseID:	FBgn0035397	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	NP_499177.3	Gene:	panl-3 / 176391	WormBaseID:	WBGene00014015	Length:	632	Species:	Caenorhabditis elegans

Alignment Length:	640	Identity:	233/640 - (36%)
Similarity:	336/640 - (52%)	Gaps:	67/640 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 QHPQKQQQHPPSVGGGAVSAASAPIAI-SGAPPNPAAAPFVSSMSAQTPLKGRGAMM------RQ 229
            |:.....:..||.|.|.....:||:.: ....|.||      .::|..|:..:.|.:      .|
Worm    30 QYLANNNRQGPSFGPGTPINVNAPVFVPKHQQPQPA------QVAAPPPMVNQFAQLSIHDVPHQ 88

  Fly   230 ESPTAAMISGA---GPGEKSPPHGMTPHGASPIPSALPTSVHQ--------ENVGGTIYFY--PT 281
            ..| ...|:|.   |||:.. .|..:.|..||..:..|.::.|        ||.|||.|||  ||
Worm    89 MIP-FGQINGPPTFGPGQHM-NHRASHHHQSPQMAQQPPTLQQSAYDRYQLENRGGTTYFYTEPT 151

  Fly   282 ANAQNSQPVVNSMVVDGTHPALHGVSAVAPMSAGVPAAMMYTGHVYPGPSSNVVTMQPK--TLLE 344
            ....:.:....:...||:            :....|.|..|..   |.|.|::...:.|  ..|:
Worm   152 EAGPDDEQYTEAEAPDGS------------ILVNTPGAFGYNA---PLPISHMARFRGKANANLQ 201

  Fly   345 SAFFMPDEMRAEVLARNEISNLIMDAAEAAQHALPLEVENYHALYPLEPPAQPLHAKLTFPATTY 409
            :.|..| |:|.|::.|....:...|:|....  :|..||::..|.|||  ...:.::     |||
Worm   202 TQFISP-EIRMELINRQLAYDTKADSAIIGD--IPHSVEHFSNLVPLE--IAGIQSQ-----TTY 256

  Fly   410 RATHNTTGYKYCLRRIHGFRLQSTKCMT-LVEMWKKLQHTNVVQLREV-FTTKAFGDNSLVLVYD 472
            :|.....|..||||||||.|:|.....| |||.||||.|.|||.|||| ...:||.|:||:..||
Worm   257 KAFSCRDGNYYCLRRIHGNRIQHPGKQTHLVEQWKKLVHGNVVPLREVLINCRAFDDSSLIFAYD 321

  Fly   473 YHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIWSIIMQLTAGLK 537
            |:|.:.||:.|:|.....|  :.||..|..  .|...|:....:|....|..|||.|:|:.|.|:
Worm   322 YYPLAGTLMEKHFDTKSGT--FFDPNNGFR--ISSPMNVSMPISGTGAHETLIWSYIIQIAAALR 382

  Fly   538 AIHHAGLACKVLDPTKIIVTGKRVRFSSCCISDITQFDPNASNPLALVNMHQQDDLTALGRLVLA 602
            |||.:||||:.||..|||..|.::..|.|.|.|:...||..      :...|.:||...|.|::|
Worm   383 AIHSSGLACRTLDLNKIITYGNKIMISFCGIQDVLDPDPTT------IQQQQNEDLNMFGNLIVA 441

  Fly   603 LACRCLQSVQRDNVQSSIDMVTRNYSTDLRNFIVYLFTTNNRRSVTDLMPMIGARFYTQLDALQS 667
            ||.......::|..|.....:...||.||||.|.:|...:.|:::.::|||||.||:|.::.:|:
Worm   442 LATGRANGWRKDLYQQLKKFIEDTYSMDLRNVIGFLHNNSTRKTINEIMPMIGGRFFTVMENMQA 506

  Fly   668 KIDMQEDELAKEMENGRLYRILVKLNSINERPDFNLDCTWSETGDRYMLKLFRDYLFHSVTEDGR 732
            |.|:.|.||::|||||||:|::.|:|::.||.:...|..|||||||:||||||||:||.||:.|:
Worm   507 KTDVLEAELSREMENGRLFRLVAKMNTVLERVEHGTDDAWSETGDRFMLKLFRDYVFHQVTDQGK 571

  Fly   733 PWLDHAHIVQCLNKLDAGSIERVQLMSRDEQSVLIVSYAELKNCLENAFSELMSS 787
            .|||.|||||||||||.||.|:::::||...:.:|:.||.||.||:.:|.:|:.:
Worm   572 AWLDMAHIVQCLNKLDCGSQEKIEMVSRSGDTQIIIDYATLKRCLDKSFRDLLGT 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN3	NP_647767.1	DUF4797	245..284	CDD:292670	16/48 (33%)
PAN3	NP_647767.1	PKc	406..>570	CDD:270622	75/165 (45%)
panl-3	NP_499177.3	PKc_like	254..>409	CDD:304357	72/158 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163629
Domainoid	1	1.000	172	1.000	Domainoid score	I2231
eggNOG	1	0.900	-	-		E1_KOG3741
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H135900
Inparanoid	1	1.050	351	1.000	Inparanoid score	I1333
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49341
OrthoDB	1	1.010	-	-		D1515085at2759
OrthoFinder	1	1.000	-	-		FOG0003944
OrthoInspector	1	1.000	-	-		oto17777
orthoMCL	1	0.900	-	-		OOG6_103887
Panther	1	1.100	-	-	LDO	PTHR12272
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2218
SonicParanoid	1	1.000	-	-		X3243
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800