Protein Alignment PAN3 and panl-3

DIOPT Version :10

• Sequence 1: NP_647767.1
• Gene: PAN3 / 38369
• FlyBaseID: FBgn0035397
• Length: 790
• Species: Drosophila melanogaster
• Sequence 2: NP_499177.3
• Gene: panl-3 / 176391
• WormBaseID: WBGene00014015
• Length: 632
• Species: Caenorhabditis elegans
• Alignment Length: 640
• Identity: 233/640 - (36%)
• Similarity: 336/640 - (52%)
• Gaps: 67/640 - (10%)

  Fly   172 QHPQKQQQHPPSVGGGAVSAASAPIAI-SGAPPNPAAAPFVSSMSAQTPLKGRGAMM------RQ 229
            |:.....:..||.|.|.....:||:.: ....|.||      .::|..|:..:.|.:      .|
 Worm    30 QYLANNNRQGPSFGPGTPINVNAPVFVPKHQQPQPA------QVAAPPPMVNQFAQLSIHDVPHQ 88

  Fly   230 ESPTAAMISGA---GPGEKSPPHGMTPHGASPIPSALPTSVHQ--------ENVGGTIYFY--PT 281
            ..| ...|:|.   |||:.. .|..:.|..||..:..|.::.|        ||.|||.|||  ||
 Worm    89 MIP-FGQINGPPTFGPGQHM-NHRASHHHQSPQMAQQPPTLQQSAYDRYQLENRGGTTYFYTEPT 151

  Fly   282 ANAQNSQPVVNSMVVDGTHPALHGVSAVAPMSAGVPAAMMYTGHVYPGPSSNVVTMQPK--TLLE 344
            ....:.:....:...||:            :....|.|..|..   |.|.|::...:.|  ..|:
 Worm   152 EAGPDDEQYTEAEAPDGS------------ILVNTPGAFGYNA---PLPISHMARFRGKANANLQ 201

  Fly   345 SAFFMPDEMRAEVLARNEISNLIMDAAEAAQHALPLEVENYHALYPLEPPAQPLHAKLTFPATTY 409
            :.|..| |:|.|::.|....:...|:|....  :|..||::..|.|||  ...:.::     |||
 Worm   202 TQFISP-EIRMELINRQLAYDTKADSAIIGD--IPHSVEHFSNLVPLE--IAGIQSQ-----TTY 256

  Fly   410 RATHNTTGYKYCLRRIHGFRLQSTKCMT-LVEMWKKLQHTNVVQLREV-FTTKAFGDNSLVLVYD 472
            :|.....|..||||||||.|:|.....| |||.||||.|.|||.|||| ...:||.|:||:..||
 Worm   257 KAFSCRDGNYYCLRRIHGNRIQHPGKQTHLVEQWKKLVHGNVVPLREVLINCRAFDDSSLIFAYD 321

  Fly   473 YHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIWSIIMQLTAGLK 537
            |:|.:.||:.|:|.....|  :.||..|..  .|...|:....:|....|..|||.|:|:.|.|:
 Worm   322 YYPLAGTLMEKHFDTKSGT--FFDPNNGFR--ISSPMNVSMPISGTGAHETLIWSYIIQIAAALR 382

  Fly   538 AIHHAGLACKVLDPTKIIVTGKRVRFSSCCISDITQFDPNASNPLALVNMHQQDDLTALGRLVLA 602
            |||.:||||:.||..|||..|.::..|.|.|.|:...||..      :...|.:||...|.|::|
 Worm   383 AIHSSGLACRTLDLNKIITYGNKIMISFCGIQDVLDPDPTT------IQQQQNEDLNMFGNLIVA 441

  Fly   603 LACRCLQSVQRDNVQSSIDMVTRNYSTDLRNFIVYLFTTNNRRSVTDLMPMIGARFYTQLDALQS 667
            ||.......::|..|.....:...||.||||.|.:|...:.|:::.::|||||.||:|.::.:|:
 Worm   442 LATGRANGWRKDLYQQLKKFIEDTYSMDLRNVIGFLHNNSTRKTINEIMPMIGGRFFTVMENMQA 506

  Fly   668 KIDMQEDELAKEMENGRLYRILVKLNSINERPDFNLDCTWSETGDRYMLKLFRDYLFHSVTEDGR 732
            |.|:.|.||::|||||||:|::.|:|::.||.:...|..|||||||:||||||||:||.||:.|:
 Worm   507 KTDVLEAELSREMENGRLFRLVAKMNTVLERVEHGTDDAWSETGDRFMLKLFRDYVFHQVTDQGK 571

  Fly   733 PWLDHAHIVQCLNKLDAGSIERVQLMSRDEQSVLIVSYAELKNCLENAFSELMSS 787
            .|||.|||||||||||.||.|:::::||...:.:|:.||.||.||:.:|.:|:.:
 Worm   572 AWLDMAHIVQCLNKLDCGSQEKIEMVSRSGDTQIIIDYATLKRCLDKSFRDLLGT 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAN3	NP_647767.1	DUF4797	245..284	CDD:435100	16/48 (33%)
		Protein Kinases, catalytic domain	409..>543	CDD:473864	60/135 (44%)
		Pan3_PK	647..784	CDD:465649	74/136 (54%)
panl-3	NP_499177.3	KLF1_2_4_N	<57..>136	CDD:425360	19/86 (22%)
		Pan3_PK	486..623	CDD:465649	74/136 (54%)