DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAN3 and pan3

DIOPT Version :9

Sequence 1:	NP_647767.1	Gene:	PAN3 / 38369	FlyBaseID:	FBgn0035397	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	NP_001099162.2	Gene:	pan3 / 100126012	ZFINID:	ZDB-GENE-070928-13	Length:	799	Species:	Danio rerio

Alignment Length:	790	Identity:	315/790 - (39%)
Similarity:	442/790 - (55%)	Gaps:	141/790 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 APMQLSNGLNGVNG--------LTAAAAAAAAA----AAAAAAAVPSSTS--------------- 133
            |.:.|..|..|..|        |:.|..|..||    ..:||:.||:|.|
Zfish    50 ASLSLHGGGTGAGGGGGGSPVSLSLAGGAVTAAGYVLGGSAASGVPASVSKKNDSLGPEGQLLSI 114

  Fly   134 ------SASSASVT---ISKTANG--GASMLALQKTASIASVTIAQQQP----------QHPQKQ 177
                  :.:.||:|   .|.|..|  |....|..|.:.:..:|.:...|          .|....
Zfish   115 PGMEGGALNEASLTNSYFSSTFIGVNGFGGPAESKYSMMQRMTSSSSSPSLLNDGAKSYSHSTHD 179

  Fly   178 QQHPPSVG----GGAVSAASAPIAISGAPPNPAAAPFV-------SSMSAQTPLKGRGAMMRQES 231
            ..:.|:..    .||:|.:....|     |||||:.||       :|||..|.......:.....
Zfish   180 PVNSPTSSLFSDFGALSISQRRKA-----PNPAASEFVPKGAPRMASMSQTTVPAFASPIFPHPG 239

  Fly   232 PTAAMISGAGPG-----EKSPPHG--MTPHGASPIPS---------------ALPTS-------- 266
            .:::..|...||     ..||.|.  :||| .||.|.               .:||:
Zfish   240 LSSSTASALAPGMSLSAGSSPLHSPKITPH-TSPAPRRRSHTPNPNPNPANYMVPTTAPDQAGGA 303

  Fly   267 --VHQENVGGTIYFYPTANAQNSQPVVNSMVVDGTHPALHGVSAVAPMSAGVPAAMMYTGHVYPG 329
              :.:|.||||.|||                .|.|...|.|:  |.|           |.|:||.
Zfish   304 HIIQKETVGGTTYFY----------------TDNTPAPLAGM--VFP-----------TYHMYPQ 339

  Fly   330 PSSNVVTMQPKTLLESAFFMPDEMRAEVLARNEISNLIMDAAEAAQHALPLEVENYHALYPLEPP 394
            .:.:|..||||....| |||.||:|.|::.|:.|:...:|.:|  ...:|.||::||:|:||||.
Zfish   340 TAPHVAYMQPKANAPS-FFMADELRQELINRHLITMAQIDQSE--NPGVPSEVDSYHSLFPLEPL 401

  Fly   395 AQPLHAKLT----FPATTYRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLRE 455
            ..|...:.|    :..:.|:|.::.....|||||||||||.:||||.||:||||:||:|.|.|||
Zfish   402 PPPNRLQKTSNFSYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMMLVDMWKKIQHSNTVTLRE 466

  Fly   456 VFTTKAFGDNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLL 520
            |||||||||:|||..||:|.|::|:.:::|......:.:|....|:     |:....|...| ||
Zfish   467 VFTTKAFGDHSLVFSYDFHAGAETMFSRHFNDPAADSYFTKRKWGQ-----HELPPPRQHAG-LL 525

  Fly   521 PEATIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGK-RVRFSSCCISDITQFDPNASNPLAL 584
            ||:.||:.|:||::.|:.||.|||||:|:||:||::||| |:|.:...:.|:..||.:.:|.|||
Zfish   526 PESLIWAYIVQLSSALRTIHTAGLACRVMDPSKILITGKTRLRVNCVGMFDVLTFDNSQTNHLAL 590

  Fly   585 VNMHQQDDLTALGRLVLALACRCLQSVQRDNVQSSIDMVTRNYSTDLRNFIVYLFTTNNR-RSVT 648
            :..:||.||.:||::||||||..|..:||:|:|.::::|:.|||:||:|.|:||.:..:| |||.
Zfish   591 MPQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVSINYSSDLKNLILYLLSEQSRLRSVN 655

  Fly   649 DLMPMIGARFYTQLDALQSKIDMQEDELAKEMENGRLYRILVKLNSINERPDFNLDCTWSETGDR 713
            |:||||||||||||||.|.:.|:.|::||||::||||:|:|.||.:|||||:|..|.||||||||
Zfish   656 DIMPMIGARFYTQLDASQMRNDVIEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTWSETGDR 720

  Fly   714 YMLKLFRDYLFHSVTEDGRPWLDHAHIVQCLNKLDAGSIERVQLMSRDEQSVLIVSYAELKNCLE 778
            |:||||||:|||.|||.|.||:|.:|||.||||||||..|::.|:||||:|||:|:|::||.|.|
Zfish   721 YLLKLFRDHLFHQVTETGTPWVDLSHIVSCLNKLDAGVPEKISLVSRDEKSVLVVTYSDLKRCFE 785

  Fly   779 NAFSELMSSA 788
            :.|.||:::|
Zfish   786 STFQELLATA 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN3	NP_647767.1	DUF4797	245..284	CDD:292670	19/65 (29%)
PAN3	NP_647767.1	PKc	406..>570	CDD:270622	80/164 (49%)
pan3	NP_001099162.2	ZnF_C3H1	21..46	CDD:214632
pan3	NP_001099162.2	PKc_like	417..>600	CDD:304357	90/188 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590042
Domainoid	1	1.000	200	1.000	Domainoid score	I2993
eggNOG	1	0.900	-	-		E1_KOG3741
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	488	1.000	Inparanoid score	I1387
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1515085at2759
OrthoFinder	1	1.000	-	-		FOG0003944
OrthoInspector	1	1.000	-	-		oto40120
orthoMCL	1	0.900	-	-		OOG6_103887
Panther	1	1.100	-	-	LDO	PTHR12272
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2218
SonicParanoid	1	1.000	-	-		X3243
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790