DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32486 and CYHR1

DIOPT Version :9

Sequence 1:	NP_647765.1	Gene:	CG32486 / 38367	FlyBaseID:	FBgn0266918	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_001317547.1	Gene:	CYHR1 / 50626	HGNCID:	17806	Length:	404	Species:	Homo sapiens

Alignment Length:	387	Identity:	178/387 - (45%)
Similarity:	258/387 - (66%)	Gaps:	29/387 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SSSTSSSSSSVGGGNVVGVPLDT-----------QGSGEP--PAKKQLLDGGGGGATSSSGSSLL 90
            :::..::::::|.....|:|.:.           :.:|:|  |.||:|       ..:.:..:..
Human    34 AAAGQAAAAALGEAAGPGLPDEAGLAGARQLQLQEAAGDPDAPPKKRL-------RAAEAAEAAA 91

  Fly    91 SSAAAASGMHEKLAHRISNALCCAVCLDLPKTAMYQCQMGHLMCAACFTHLLADGRLRDQIATCP 155
            ::|||.||   ||..|:.:.|||.|||||||.::|||..||||||.||.|||||.||:::.||||
Human    92 AAAAAGSG---KLEERLYSVLCCTVCLDLPKASVYQCTNGHLMCAGCFIHLLADARLKEEQATCP 153

  Fly   156 NCRVEISKSTASRNLAVEKAASELPSECQFCNKEFPYKSLERHEQHECQERPTKCKYHRIGCQWR 220
            |||.|||||...||||||||.|||||||.||.::||...||||::.|||:|.|:|||.||||.|.
Human   154 NCRCEISKSLCCRNLAVEKAVSELPSECGFCLRQFPRSLLERHQKEECQDRVTQCKYKRIGCPWH 218

  Fly   221 GPYHETNEHERNCLHPQKSGYEVMAALEAHDDRIKEEKKMFNTLIDLLSYEKIIFNDLQMKPYRT 285
            ||:||...||..|.||.|:|.|:|..|:..|...::|.:::|::..|||:|||.:.::|.:||||
Human   219 GPFHELTVHEAACAHPTKTGSELMEILDGMDQSHRKEMQLYNSIFSLLSFEKIGYTEVQFRPYRT 283

  Fly   286 DEYVHKLFYETARFSAFNQQWVVKARINNSQRDPHQSNERTITYQLILKTKTSTPMSIHFFALKG 350
            |:::.:|:|||.||:..||.||:|||:|:|:|:|:.|.:||:::||:||:|.:.|:...|..|||
Human   284 DDFITRLYYETPRFTVLNQTWVLKARVNDSERNPNLSCKRTLSFQLLLKSKVTAPLECSFLLLKG 348

  Fly   351 PFSDMKVSTQIYKHEFTETSTESEYYVLPLPDGVGGSGSSECNRMLANKGINFRLLMFLLNK 412
            |:.|:::|..||...||..|.|::|..||:.|.|      |||::||.|.||.||.:|.:.|
Human   349 PYDDVRISPVIYHFVFTNESNETDYVPLPIIDSV------ECNKLLAAKNINLRLFLFQIQK 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32486	NP_647765.1	zf-C3HC4_3	109..164	CDD:290631	38/54 (70%)
CG32486	NP_647765.1	Sina	168..>232	CDD:302762	42/63 (67%)
CYHR1	NP_001317547.1	RING-HC_CYHR1	108..156	CDD:319419	33/47 (70%)
		RING-HC finger (C3HC4-type)	111..155	CDD:319419	30/43 (70%)
		Sina	166..>227	CDD:388509	40/60 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140673
Domainoid	1	1.000	270	1.000	Domainoid score	I1834
eggNOG	1	0.900	-	-		E1_KOG3002
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32791
Inparanoid	1	1.050	332	1.000	Inparanoid score	I2437
Isobase	1	0.950	-	0	Normalized mean entropy	S5622
OMA	1	1.010	-	-		QHG48416
OrthoDB	1	1.010	-	-		D1174688at2759
OrthoFinder	1	1.000	-	-		FOG0007898
OrthoInspector	1	1.000	-	-		oto89433
orthoMCL	1	0.900	-	-		OOG6_109690
Panther	1	1.100	-	-	LDO	PTHR23059
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4529
SonicParanoid	1	1.000	-	-		X1167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750