DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1271 and MPA43

DIOPT Version :9

Sequence 1:	NP_647763.1	Gene:	CG1271 / 38364	FlyBaseID:	FBgn0035392	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_014150.1	Gene:	MPA43 / 855472	SGDID:	S000005193	Length:	542	Species:	Saccharomyces cerevisiae

Alignment Length:	589	Identity:	115/589 - (19%)
Similarity:	199/589 - (33%)	Gaps:	195/589 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LALDVGTTCVR----SFVLDEQCEVRGSAVDAVELLNPQPGYFEIEPES--LWRK---IVGVITQ 89
            :.:|||::..|    ::..|...|:      |.|   |.|.|.:...:|  .|:|   |:..:.:
Yeast     9 IGIDVGSSSARIGVYNYYNDALLEM------AQE---PVPYYQDSSKKSWKFWQKSTEIIKALQK 64

  Fly    90 AVKNAQLTPPDI-TCLTISTQRCTFLTWDHRSGEYY-----HNFITWKDLRADELVDQWNASWTK 148
            .::...:...:: :|...:|........|..|....     .|.|.|.|               .
Yeast    65 CLQKLNIREYEVKSCGVSATCSLAIFERDRTSNMLIPYPNEDNVIFWMD---------------S 114

  Fly   149 SSMNWFSYALFLLTRQSRFLAGSVLQLMNGQVTPRLLFEIMNNKKLKQALMQKKARVELLDSWIL 213
            |::|...:......:|       :|..:.|:..|.     |...|||.          .||.:
Yeast   115 SAVNECQWLNMQCPQQ-------LLDYLGGKFVPE-----MGVPKLKY----------FLDEY-- 155

  Fly   214 HKLRTGSSRDKDVEHITDVTSSTATGLYDPFTLSWSPLISWLFGINSKILPRVVDNGYKGFGHVH 278
                 ...|||.. ||.|        |:.......|.|..|..   ..:|.|...||....|.|
Yeast   156 -----SHLRDKHF-HIFD--------LHQYIAYELSRLYEWNI---EGLLGRENLNGIGNDGEV- 202

  Fly   279 PTAFGPDWANTEIPIAASLSDQTAAIWGSQCFQKNDV----KVTMGTGAFLNLVTGDRCQAVI-- 337
                 ..|                    |..|.||.:    .|::||   .:||........:
Yeast   203 -----SGW--------------------SSSFYKNIINLPSNVSIGT---TSLVANKHISTTVVR 239

  Fly   338 SGMYPLVAWQFKKPTRQQGAVYCIEGAS--HDFGTVVT-------W------------------A 375
            |.:....:|........:.:::.|.|.|  :.:||.::       |                  .
Yeast   240 SCIDSYASWFAVASPHLETSLFMIAGTSSCYMYGTTISDTRIPGVWGPFDTILDNRGDFSVYAAG 304

  Fly   376 QSC------ELFDS-PA------NTSDI----AQSVPD------------TNDVFFMPAFSGLGP 411
            |||      .||:| |.      :.:||    .|::.|            |.|:||...:.|...
Yeast   305 QSCTGKLIEHLFESHPCARKILKDGADIYQVLEQTIRDIEKNNGLSIHILTKDMFFYGDYEGNRT 369

  Fly   412 PVNDYRSASGFIGLTPSTTKAHMVR---ALLESIVFRLVQLIEAAEKETSQKLHM--IRVDGGVS 471
            |..|.|....|||.:..|:..::..   .:||.:.|:...:|:..:.|.| .:|:  :|:.|..:
Yeast   370 PFADPRIKGSFIGESTDTSMLNLTYKYICILEFLSFQTKLIIDTFQNENS-NIHIKELRISGSQA 433

  Fly   472 RNDFVCQFLADLSRLR-----VERADNAE-SSIMGATFMAG--------INLGIWRDV-NDLKRF 521
            :|:   :.|:.:|.:.     ::..:|.: ..|.||..:|.        .::...||: ||.::|
Yeast   434 KNE---RLLSLISLVNNGVAIIKPKENVDMMGIKGAYVLAKSAKEKKQLADVITERDISNDSEKF 495

  Fly   522 RKVA 525
            ..:|
Yeast   496 ESLA 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1271	NP_647763.1	GlpK	32..555	CDD:223628	115/589 (20%)
CG1271	NP_647763.1	FGGY_GK5_metazoa	32..552	CDD:212665	115/589 (20%)
MPA43	NP_014150.1	AraB	4..542	CDD:223995	115/589 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900