Protein Alignment CG1271 and FGGY

DIOPT Version :10

• Sequence 1: NP_647763.1
• Gene: CG1271 / 38364
• FlyBaseID: FBgn0035392
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_001106882.1
• Gene: FGGY / 55277
• HGNCID: 25610
• Length: 575
• Species: Homo sapiens
• Alignment Length: 632
• Identity: 135/632 - (21%)
• Similarity: 218/632 - (34%)
• Gaps: 160/632 - (25%)

  Fly    24 SGPPDSP-AFILALDVGTTCVRSFVLDEQCEVRGSAVDAVELLNPQPGYFEIEPESLWRKIVGVI 87
            ||....| .:.:.:||||..||:.::|:...:...|...::...||..:.|...|.:|.....|.
Human     2 SGGEQKPERYYVGVDVGTGSVRAALVDQSGVLLAFADQPIKNWEPQFNHHEQSSEDIWAACCVVT 66

  Fly    88 TQAVKNAQLTPP-----DITCLTISTQRCTFLTWDHRSGEYYHNFITWKDLRADELVDQWNASWT 147
            .:.|:...|...     |.||..:...:.......::.|:.:.|.|.|.|.||...|::.|.  |
Human    67 KKVVQGIDLNQIRGLGFDATCSLVVLDKQFHPLPVNQEGDSHRNVIMWLDHRAVSQVNRINE--T 129

  Fly   148 KSSMNWFSYALFLLTRQSRFLAGSVLQLMNGQVT-----PRLLFEIMNNKKLKQALMQKKAR-VE 206
            |.                     ||||.:.|.::     |:||:   ..:.|::....|... .:
Human   130 KH---------------------SVLQYVGGVMSVEMQAPKLLW---LKENLREICWDKAGHFFD 170

  Fly   207 LLD--SWILHKLRTGSSRDKDVEHITDVTSSTATGLYDPFTLS----WSPLISWLFGIN------ 259
            |.|  ||                ..|.||:.:...|...:|.|    |......:.|:.
Human   171 LPDFLSW----------------KATGVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDFVADN 219

  Fly   260 -SKILPRVVDNGYKGFGHVHPTAFGPDWANTEIPIAASLSD------------------------ 299
             |||..:|:..|......:.|.|.........|.:||||.|
Human   220 YSKIGNQVLPPGASLGNGLTPEAARDLGLLPGIAVAASLIDAHAGGLGVIGADVRGHGLICEGQP 284

  Fly   300 ---QTAAIWG-SQC---FQKNDVKV---------TMGTGAFLN----LVTGDRCQAVISGMYPLV 344
               :.|.|.| |.|   ..|:.:.|         .|..|.:||    .|||.....::.|.....
Human   285 VTSRLAVICGTSSCHMGISKDPIFVPGVWGPYFSAMVPGFWLNEGGQSVTGKLIDHMVQGHAAFP 349

  Fly   345 AWQFKKPTRQQGAVYCIEGASHD---------FGTV--VTWAQSCELFDSPANTS---DIAQSVP 395
            ..|.|...|.| ::|....:..|         |.||  ..|.      |...|.|   |:.....
Human   350 ELQVKATARCQ-SIYAYLNSHLDLIKKAQPVGFLTVDLHVWP------DFHGNRSPLADLTLKGM 407

  Fly   396 DTNDVFFMPAFSGLGPPVNDYRSASGFIGLTPSTT----------KAHMVRALLESIVFRLVQLI 450
            .|....::||.:.|..|.:         .|:|..|          .|.:..|.:::|......:|
Human   408 RTTGYLYIPALAALHSPSS---------LLSPQVTGLKLSQDLDDLAILYLATVQAIALGTRFII 463

  Fly   451 EAAEKETSQKLHMIRVDGGVSRNDFVCQFLADLSRLRVERADNAESSIMGATFMAGINLGIWRDV 515
            ||.| .....:..:.:.||:|:|....|..||::.:.|..:...||.::||..:.....|.:..|
Human   464 EAME-AAGHSISTLFLCGGLSKNPLFVQMHADITGMPVVLSQEVESVLVGAAVLGACASGDFASV 527

  Fly   516 ND-LKRFRKVARVFEPR-------PKEYETIANRMDKWSRTIARFSD 554
            .: :.:..||.:|..||       .|:|:.....::.....:|..:|
Human   528 QEAMAKMSKVGKVVFPRLQDKKYYDKKYQVFLKLVEHQKEYLAIMND 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1271	NP_647763.1	ASKHA_NBD_FGGY_GK5-like	32..549	CDD:466803	130/616 (21%)
FGGY	NP_001106882.1	ASKHA_NBD_FGGY_D-RBK	11..568	CDD:466800	130/615 (21%)