DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1271 and Gk1

DIOPT Version :9

Sequence 1:	NP_647763.1	Gene:	CG1271 / 38364	FlyBaseID:	FBgn0035392	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	158/561 - (28%)
Similarity:	251/561 - (44%)	Gaps:	62/561 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DSQCAEESGPPD--SPAFILALDVGTTCVRSFVL----DE-----QCEVRGSAVDAVELLNPQPG 70
            ||...|.:.||.  |..|:.|:|.|||..|..:.    ||     |.|        ||.:..:.|
  Fly     2 DSPTTETTPPPPTLSGPFVGAIDEGTTSARFIIFRAGTDEIVCFHQIE--------VESIFQKEG 58

  Fly    71 YFEIEPESLWRKIVGVITQAVKNAQLT---PPDITCLTISTQRCTFLTWDHRSGEYYHNFITWKD 132
            :.|.:|.::...:...||.|.|.....   ..:|..:.|:.||.:.:.||..||:...|.|.|.|
  Fly    59 WCEQDPMAIVNTVNECITGACKKLVAVGGKVEEIITIGITNQRESTVVWDRNSGQPLVNAIIWLD 123

  Fly   133 LRADELVDQWNASWTKSSMNWFSYALFLLTRQSRFLAGSVLQLMNGQVTPRLLFEIMNNKKLKQA 197
            .|....|::...:...::.| .:|.        |.|.|..|......|..|.|.:  |...:.||
  Fly   124 NRTTSTVEELLETIPNNARN-INYL--------RPLCGLPLSPYFSGVKLRWLRD--NVPVVSQA 177

  Fly   198 LMQKKARVELLDSWILHKLRTGSSRDKDVEHITDVTSSTATGLYDPFTLSWSPLISWLFGINSKI 262
            :.:..|....:|:|:::.|..|  :|..| |.||||:::.|.|.:..||.|...:...||:...|
  Fly   178 MEKGTAMFGTIDTWLMYNLTGG--KDCGV-HKTDVTNASRTMLMNIETLQWDANLLKFFGLPKTI 239

  Fly   263 LPRVVDNGYKGFGHVHPTAFGPDWANTEIPIAASLSDQTAAIWGSQCFQKNDVKVTMGTGAFLNL 327
            ||.:..:. :.:|.:.....      ..|.|.:.|.||.||:.|.||..|...|.|.|||.||..
  Fly   240 LPEICSSS-EFYGSIAQGVL------QGIGITSVLGDQQAALVGQQCLAKGQAKATYGTGCFLLY 297

  Fly   328 VTGDRCQAVISGMYPLVAWQFKKPTRQQGAVYCIEGASHDFGTVVTWAQ-SCELFDSPANTSDIA 391
            .||........|:...|.:|.   .|:....|.:||:....|....|.: :..|..:......:|
  Fly   298 NTGPSIVHSTHGLLTTVGYQL---GRKAVPFYALEGSVSIAGAAFNWLRDNMNLIQNSGQIETMA 359

  Fly   392 QSVPDTNDVFFMPAFSGLGPPVNDYRSASGFIGLTPSTTKAHMVRALLESIVFRLVQLIEAAEKE 456
            .:|.::.||:|:|||:||..|..:..:.....||:..||..|:|||.||::.|::..::::..|:
  Fly   360 STVDNSLDVYFVPAFNGLYAPYWNQDARGVICGLSEETTSEHIVRATLEAVCFQVRDILDSMHKD 424

  Fly   457 TSQKLHMIRVDGGVSRNDFVCQFLADLSRLRVERADNAESSIMGATFMAGINLGIWRDVNDLKRF 521
            ....|..:.||||::.|:...|..:||..::|.||..||::.:||...|      ::.|.:  |:
  Fly   425 CKIPLAKLMVDGGMTVNNLFLQLQSDLVGIQVLRAKIAETTALGAAMAA------YKAVEN--RY 481

  Fly   522 RKVARVFEPRPKE------YETIAN-RMDKWSRTIARFSDW 555
            :..|.:.:..|:|      ..|..| |..||...|.|..:|
  Fly   482 QMEAPLSKSGPREAIKPSISATDRNLRYQKWKMAIDRSLNW 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1271	NP_647763.1	GlpK	32..555	CDD:223628	151/542 (28%)
CG1271	NP_647763.1	FGGY_GK5_metazoa	32..552	CDD:212665	150/539 (28%)
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	151/543 (28%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	151/543 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443072
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850