DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1271 and CG11594

DIOPT Version :9

Sequence 1:	NP_647763.1	Gene:	CG1271 / 38364	FlyBaseID:	FBgn0035392	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001261391.1	Gene:	CG11594 / 38473	FlyBaseID:	FBgn0035484	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	565	Identity:	118/565 - (20%)
Similarity:	198/565 - (35%)	Gaps:	152/565 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SGPPDSPAFILALDVGTTCVRSFVLDEQCEVRGSAVDAVELLNPQPGYFEIEPESLWRKIVGVIT 88
            |||     |.:.:||||...|:.::.....|...||..::..||:|||:....:::|:.|..|:.
  Fly     3 SGP-----FFVGVDVGTGSARAALVACDGRVLEQAVQTIQTWNPEPGYYNQSSDNIWQSICQVVK 62

  Fly    89 QAVKNAQLTPP-----DITC-----------LTISTQRCTFLTWDHRSGEYYHNFITWKDLRADE 137
            :.:.....:..     |.||           ||:|           :|||...|.|.|.|.||::
  Fly    63 KVIGGVDKSKVKGIGFDATCSLVVLGPQGSPLTVS-----------KSGEAEQNIILWMDHRAEQ 116

  Fly   138 LVDQWNASWTKSSMNWFSYALFLLTRQSRFLAGSVLQLMNGQVT-----PRLLFEIMNNKKLKQA 197
            ...:.||         |.:              |:|:.:.|||:     |:||:       ||:.
  Fly   117 ETQEINA---------FKH--------------SLLKYVGGQVSLEMEVPKLLW-------LKRN 151

  Fly   198 LMQKKARVELLDSWILHKLRTGSSRDKDVEHITDVTSSTATGL-------------YDPFTLSWS 249
            |.|....:     |             .|..:.|..:..|||:             ||....||:
  Fly   152 LSQTFGNI-----W-------------RVFDLPDFLTWRATGVDTRSLCSVVCKWNYDAANGSWN 198

  Fly   250 PLISWLFGINSKILPRVVDNGYKGFG-HVHP-----------TAFGPDWANTEIPIAASLSDQTA 302
            ...     :....|..:..|.::..| .|.|           .|.|....:....::.||.|..|
  Fly   199 KEF-----LKQADLEELTQNNFEKLGSDVQPPGRTVGKGLTAKAAGELGLSAGTVVSTSLIDAHA 258

  Fly   303 AIWGS-QCFQK-----NDVKVTM----GTGAFLNLVTGDRCQAV-ISGMY--PLVAWQFKKPTRQ 354
            ...|. .|..|     :||:..|    ||......:|...|.|. :.|.|  .::...|.....|
  Fly   259 GALGMFGCRSKESKGADDVQGKMALIAGTSTCHMSITRKACFAQGVWGPYQDAIIPGYFLNEGGQ 323

  Fly   355 QGAVYCIEGA--SHDFGTVVTWAQ-SCELFDSPANTSDIAQSVPD-------------TNDVFFM 403
            ..|.:.::..  ||:     ::|: ..:|.:.......:.:.:|:             |.||...
  Fly   324 SIAGHLLDHVLKSHE-----SYAELKSQLGEDKFIYQHLNKLLPELAAARGLSQVGCLTQDVHVW 383

  Fly   404 PAFSGLGPPVND--YRSASGFIGLTPST-TKAHMVRALLESIVFRLVQLIEAAEKETSQKLHMIR 465
            |...|...|:.|  .|.....:.:|..| :.|....|.::::.:....:||...:........:.
  Fly   384 PDLHGNRSPIADPTLRGVITGLDMTRGTESLAIKYLAFVQALAYGTRHIIENLYQYGRAPFQTLL 448

  Fly   466 VDGGVSRNDFVCQFLADLSRLRVERADNAESSIMGATFMAGINLG 510
            ..||:::|....|..||:..|.....|..|..::||..:.....|
  Fly   449 FCGGLAKNPLYVQCHADICNLPALIPDEQEMVLVGAAALGAAASG 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1271	NP_647763.1	GlpK	32..555	CDD:223628	115/557 (21%)
CG1271	NP_647763.1	FGGY_GK5_metazoa	32..552	CDD:212665	115/557 (21%)
CG11594	NP_001261391.1	FGGY_YpCarbK_like	5..540	CDD:212663	116/563 (21%)
CG11594	NP_001261391.1	5C_CHO_kinase	6..540	CDD:273552	115/557 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443086
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740