DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1271 and Gykl1

DIOPT Version :9

Sequence 1:	NP_647763.1	Gene:	CG1271 / 38364	FlyBaseID:	FBgn0035392	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_599168.1	Gene:	Gykl1 / 291468	RGDID:	1305596	Length:	549	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	153/552 - (27%)
Similarity:	252/552 - (45%)	Gaps:	65/552 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DSPAFIL-----ALDVGTTCVRSFVLDEQ-----CEVRGSAVDAVELLN--PQPGYFEIEPESLW 80
            |:|..:|     |:|.||:..|..|.:.|     |.      ..||:..  |:.|:.|.:|:.:.
  Rat     3 DAPKAVLGPLVGAVDQGTSSTRFLVFNPQTAELLCH------HQVEIAQEFPREGWVEQDPKVIL 61

  Fly    81 RKIVGVITQAVKNAQLTPPDIT---CLTISTQRCTFLTWDHRSGEYYHNFITWKDLRADELVDQW 142
            :.:...|.:..:.......||:   .:.::.||.|.:.||..:||..:|.:.|.|||....|:..
  Rat    62 QSVYECIEKTCEKLGQQSIDISNIKAIGVTNQRETTIVWDKFTGEPLYNAVVWLDLRTQSTVENL 126

  Fly   143 NASWTKSSMNWFSYALFLLTRQSRFLAGSVLQLMNGQVTPRLLFEIMNNKKLKQALMQKKARVEL 207
            |.| ..:|.|:.           :...|..:......|  :|.:.|.|.|.:::|:...:|....
  Rat   127 NKS-ISASNNFI-----------KIKTGLPISTYFSAV--KLHWLIENVKNVQKAIEDGRAFFGT 177

  Fly   208 LDSWILHKLRTGSSRDKDVEHITDVTSSTATGLYDPFTLSWSPLISWLFGINSKILPRVVDN--- 269
            :|||::..:..|.:..   .|.|||::::.|.|::..:|.|...:...|||...||||:..:
  Rat   178 VDSWLIWCMTGGINGG---VHCTDVSNASRTMLFNIHSLQWDEELCEFFGIPMTILPRIRSSSEI 239

  Fly   270 -GYKGFGHVHPTAFGPDWANTEIPIAASLSDQTAAIWGSQCFQKNDVKVTMGTGAFLNLVTGDRC 333
             |....|.:.           .:||:..|.||:||:.|..|.|....|.|.|||.||...||.:|
  Rat   240 YGLMKSGVLE-----------GVPISGCLGDQSAALVGQLCLQDGQAKSTYGTGCFLLCNTGQKC 293

  Fly   334 QAVISGMYPLVAWQFKKPTRQQGAVYCIEGASHDFGTVVTWAQ-SCELFDSPANTSDIAQSVPDT 397
            .....|:...||:   |..|::...|.:||:....|.||:|.: :.::..|.::...:|:....:
  Rat   294 VNSDHGLLTTVAY---KMGREEPVYYALEGSVAIAGAVVSWLKNNLQIIKSSSDIEKLAEKAGTS 355

  Fly   398 NDVFFMPAFSGLGPPVNDYRSASGFI-GLTPSTTKAHMVRALLESIVFRLVQLIEAAEKETSQKL 461
            ...:|:||||||..|..| .||.|.| |||..|.|.|:..|.||::.|:..::::|...:....|
  Rat   356 YGCYFVPAFSGLYAPYWD-PSARGIICGLTQFTNKFHIAFAALEAVCFQTREILDAMNSDCGIPL 419

  Fly   462 HMIRVDGGVSRNDFVCQFLADLSRLRVERADNAESSIMGATFMAGINLGI--WR-DVNDLKRFRK 523
            ..::||||::.|..:.|..||:..:.|.:....|::.:||...||...||  |. |..||...:
  Rat   420 THLQVDGGMTANKILMQLQADILCIPVMKPFMPETTALGAAMAAGAAEGIRVWSLDPKDLTGVQ- 483

  Fly   524 VARVFEPRPKEYETIANRMDKWSRTIARFSDW 555
             ...|||:....|: ..|...|.|.:.:...|
  Rat   484 -MEKFEPQINVEES-EGRYSTWKRAVMKSMGW 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1271	NP_647763.1	GlpK	32..555	CDD:223628	150/546 (27%)
CG1271	NP_647763.1	FGGY_GK5_metazoa	32..552	CDD:212665	150/543 (28%)
Gykl1	NP_599168.1	glycerol_kin	11..513	CDD:273549	149/542 (27%)
Gykl1	NP_599168.1	FGGY_GK1-3_metazoa	11..513	CDD:212664	149/542 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820