DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1271 and ATAD2

DIOPT Version :9

Sequence 1:	NP_647763.1	Gene:	CG1271 / 38364	FlyBaseID:	FBgn0035392	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_054828.2	Gene:	ATAD2 / 29028	HGNCID:	30123	Length:	1390	Species:	Homo sapiens

Alignment Length:	614	Identity:	108/614 - (17%)
Similarity:	186/614 - (30%)	Gaps:	232/614 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ILALDVGTTCVRSFVLDEQCEV----RGSAVDAVELLNPQPGYFEIE-----PESLWRKIVGVIT 88
            :|||..|        ||.:.|:    ..:.:|:::....:||.|:.|     |:...||.:..|.
Human   555 LLALMDG--------LDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIH 611

  Fly    89 QAVKNAQLTPPDITCLTISTQRCT-FLTWDHRS-----------GEYYHNFITWKDLRADELVDQ 141
            ....|.:  |.| |.|....:.|. :...|.:|           ..|...:.|.:.|:.|
Human   612 TRDWNPK--PLD-TFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLD----- 668

  Fly   142 WNASWTKSSMNWFSYALFLLTRQSRFLAGSVLQLMNGQVTPRLLFEIMNN--KKLKQALMQKKAR 204
                  .||:| .|...|.:..|....|........||....::..::.|  .|:.:||.:....
Human   669 ------LSSIN-ISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKILEALQRVFPH 726

  Fly   205 VELLDSWILHKLRTGSSRDKDVE----------HITDVTSSTATGL------------------- 240
            .|         .||..:.|.|:.          ...||.|....||
Human   727 AE---------FRTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHLNR 782

  Fly   241 ---YDPFTLSWSPLISWLFGINSKILPRVVDNGYKGFG---HVHP---------TAFGPDWANTE 290
               |.|.:..                ||::..|..|||   |:.|         |.:     ..:
Human   783 NACYQPMSFR----------------PRILIVGEPGFGQGSHLAPAVIHALEKFTVY-----TLD 826

  Fly   291 IPIAASLSDQTAAIWGSQCFQK-NDVKVTMGTGAFLNLVTGDRCQAVISGMYPLVAWQFKKPTRQ 354
            ||:...:|..:..   ..|.|. .:.|.|              ..:::...:..|.|:...||.:
Human   827 IPVLFGVSTTSPE---ETCAQVIREAKRT--------------APSIVYVPHIHVWWEIVGPTLK 874

  Fly   355 QGAVYCIEGASHDFGTVVTWAQSCELFDSPA---NTSDIAQS-VPDTNDVFFMPAFSGL-GPPVN 414
                          .|..|..|:...| :|.   .|||...| :|:.....|:..:..: ...:.
Human   875 --------------ATFTTLLQNIPSF-APVLLLATSDKPHSALPEEVQELFIRDYGEIFNVQLP 924

  Fly   415 DYRSASGFI-------GLTPSTTKAHMVRALLE-----------SIVFRLVQLIEAAEKETSQKL 461
            |....:.|.       ...|..:|...|...||           |:....|:.:|..|::|.::|
Human   925 DKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLPVAPPPEPRSLTAEEVKRLEEQEEDTFREL 989

  Fly   462 HMIRVDGGVSRNDFVCQFLADLS-RLRVERADNAESSIMGATFMAGINLGIWRDVNDLKRFRKVA 525
            .:               ||.::: ||.::                             ||||...
Human   990 RI---------------FLRNVTHRLAID-----------------------------KRFRVFT 1010

  Fly   526 RVFEP-----------RPKEYETIANRMD 543
            :..:|           :|.:..::.:::|
Human  1011 KPVDPDEVPDYVTVIKQPMDLSSVISKID 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1271	NP_647763.1	GlpK	32..555	CDD:223628	108/614 (18%)
CG1271	NP_647763.1	FGGY_GK5_metazoa	32..552	CDD:212665	108/614 (18%)
ATAD2	NP_054828.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..63
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..380
		AAA	459..600	CDD:214640	12/52 (23%)
		AAA	464..598	CDD:278434	12/50 (24%)
		COG5076	<915..1153	CDD:227408	24/169 (14%)
		Bromo_AAA	987..1097	CDD:99957	12/97 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1124..1163
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1242
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900