Protein Alignment CG1271 and GK2

DIOPT Version :10

• Sequence 1: NP_647763.1
• Gene: CG1271 / 38364
• FlyBaseID: FBgn0035392
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_149991.2
• Gene: GK2 / 2712
• HGNCID: 4291
• Length: 553
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 148/582 - (25%)
• Similarity: 258/582 - (44%)
• Gaps: 96/582 - (16%)

  Fly     1 MSAPSKVAAKPAGAAKDSQCAEESGPPDSPAFILALDVGTTCVRSFVLDEQCEVRGSAVDAVELL 65
            |:||...|..|                    .:.|:..||...|..|.:.:         ..|||
Human     1 MAAPKTAAVGP--------------------LVGAVVQGTNSTRFLVFNSK---------TAELL 36

  Fly    66 N----------PQPGYFEIEPESLWRKIVGVITQAVKNAQLTPPDIT---CLTISTQRCTFLTWD 117
            :          |:.|:.|.:|:.:.:.:...|.:..:.......||:   .:.:|.||.|.:.||
Human    37 SHHKVELTQEFPKEGWVEQDPKEILQSVYECIARTCEKLDELNIDISNIKAVGVSNQRETTVIWD 101

  Fly   118 HRSGEYYHNFITWKDLRADELVDQ------WNASWTKSSMNWFSYALFLLTRQSRFLAGSVLQLM 176
            ..:||..:|.:.|.|||....|:.      .|:::.||...        |...:.|.|
Human   102 KLTGEPLYNAVVWLDLRTQTTVEDLSKKIPGNSNFVKSKTG--------LPLSTYFSA------- 151

  Fly   177 NGQVTPRLLFEIMNNKKLKQALMQKKARVELLDSWILHKLRTGSSRDKDVEHITDVTSSTATGLY 241
                 .:|.:.:.|.:.:::|:.:.:|....:|||::..|..|.:..   .|.||||:::.|.|:
Human   152 -----VKLRWMLDNVRNVQKAVEEGRALFGTIDSWLIWSLTGGVNGG---VHCTDVTNASRTMLF 208

  Fly   242 DPFTLSWSPLISWLFGINSKILPRVVDNGYKGFGHVHPTAFGPDWANTEIPIAASLSDQTAAIWG 306
            :..:|.|...:...|.|...:||.|..:. :.:|.:...|.      ..:||:..|.||.||:.|
Human   209 NIHSLEWDKELCDFFEIPMDLLPNVFSSS-EIYGLIKTGAL------EGVPISGCLGDQCAALVG 266

  Fly   307 SQCFQKNDVKVTMGTGAFLNLVTGDRCQAVISGMYPLVAWQFKKPTRQQGAVYCIEGASHDFGTV 371
            ..|||:...|.|.|||.||...||.:|.....|:...||:   |..|::.|.|.:||:....|.|
Human   267 QMCFQEGQAKNTYGTGCFLLCNTGRKCVFSEHGLLTTVAY---KLGREKPAYYALEGSVAIAGAV 328

  Fly   372 VTWAQ-SCELFDSPANTSDIAQSVPDTNDVFFMPAFSGLGPPVNDYRSASGFI-GLTPSTTKAHM 434
            :.|.: :..:.::..:...:|:.|..:...:|:||||||..|..: .||.|.: |||..|.|.|:
Human   329 IRWLRDNLGIIETSGDIERLAKEVGTSYGCYFVPAFSGLYAPYWE-PSARGILCGLTQFTNKCHI 392

  Fly   435 VRALLESIVFRLVQLIEAAEKETSQKLHMIRVDGGVSRNDFVCQFLADLSRLRVERADNAESSIM 499
            ..|.||::.|:..:::||..::....|..::||||::.|..:.|..||:..:.|.:....|::.:
Human   393 AFAALEAVCFQTREILEAMNRDCGIPLRHLQVDGGMTNNKVLMQLQADILHIPVIKPFMPETTAL 457

  Fly   500 GATFMAGI--NLGIW----RDVNDLKRFRKVARVFEPRPKEYETIANRMDKWSRTIARFSDW 555
            ||...||.  .:.:|    :.::.|:..|     |||:.:..|: ..|...|.:.:.:...|
Human   458 GAAMAAGAAEGVSVWSLEPQALSVLRMER-----FEPQIQATES-EIRYATWKKAVMKSMGW 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1271	NP_647763.1	ASKHA_NBD_FGGY_GK5-like	32..549	CDD:466803	142/543 (26%)
GK2	NP_149991.2	ASKHA_NBD_FGGY_GK1-3-like	11..510	CDD:466802	143/567 (25%)