DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1271 and GK

DIOPT Version :9

Sequence 1:	NP_647763.1	Gene:	CG1271 / 38364	FlyBaseID:	FBgn0035392	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	XP_011543793.1	Gene:	GK / 2710	HGNCID:	4289	Length:	587	Species:	Homo sapiens

Alignment Length:	578	Identity:	153/578 - (26%)
Similarity:	248/578 - (42%)	Gaps:	102/578 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ALDVGTTCVRSFVLDEQCEVRGSAVDAVELLN----------PQPGYFEIEPESLWRKIVGVITQ 89
            |:|.||:..|..|.:.:         ..|||:          |:.|:.|.:|:.:...:...|.:
Human    15 AVDQGTSSTRFLVFNSK---------TAELLSHHQVEIKQEFPREGWVEQDPKEILHSVYECIEK 70

  Fly    90 AV-KNAQLT--PPDITCLTISTQRCTFLTWDHRSGEYYHNFI----------------------- 128
            .. |..||.  ..:|..:.:|.||.|.:.||..:||..:|.:
Human    71 TCEKLGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVAAPVSPGPSVPVAVVPSGSSVPA 135

  Fly   129 -----TWKDLRADELVDQ------WNASWTKSSMNWFSYALFLLTRQSRFLAGSVLQLMNGQVTP 182
                 .|.|||....|:.      .|.::.||.                  .|..|......|..
Human   136 PGTSSVWLDLRTQSTVESLSKRIPGNNNFVKSK------------------TGLPLSTYFSAVKL 182

  Fly   183 RLLFEIMNNKKLKQALMQKKARVELLDSWILHKLRTGSSRDKDVEHITDVTSSTATGLYDPFTLS 247
            |.|.:  |.:|:::|:.:|:|....:|||::..|..|.:..   .|.||||:::.|.|::..:|.
Human   183 RWLLD--NVRKVQKAVEEKRALFGTIDSWLIWSLTGGVNGG---VHCTDVTNASRTMLFNIHSLE 242

  Fly   248 WSPLISWLFGINSKILPRVVDNG--YKGFGHVHPTAFGPDWANTEIPIAASLSDQTAAIWGSQCF 310
            |...:...|||..:|||.|..:.  |......|....|   |...:||:..|.||:||:.|..||
Human   243 WDKQLCEFFGIPMEILPNVRSSSEIYGLMKISHSVKAG---ALEGVPISGCLGDQSAALVGQMCF 304

  Fly   311 QKNDVKVTMGTGAFLNLVTGDRCQAVISGMYPLVAWQFKKPTRQQGAVYCIEGASHDFGTVVTWA 375
            |....|.|.|||.||...||.:|.....|:...||:   |..|.:...|.:||:....|.|:.|.
Human   305 QIGQAKNTYGTGCFLLCNTGHKCVFSDHGLLTTVAY---KLGRDKPVYYALEGSVAIAGAVIRWL 366

  Fly   376 Q-SCELFDSPANTSDIAQSVPDTNDVFFMPAFSGLGPPVNDYRSASGFI-GLTPSTTKAHMVRAL 438
            : :..:..:......:|:.|..:...:|:||||||..|..: .||.|.| |||..|.|.|:..|.
Human   367 RDNLGIIKTSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWE-PSARGIICGLTQFTNKCHIAFAA 430

  Fly   439 LESIVFRLVQLIEAAEKETSQKLHMIRVDGGVSRNDFVCQFLADLSRLRVERADNAESSIMGATF 503
            ||::.|:..::::|..::....|..::||||::.|..:.|..||:..:.|.:....|::.:||..
Human   431 LEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAM 495

  Fly   504 MAGI--NLGIW----RDVNDLKRFRKVARVFEPRPKEYETIANRMDKWSRTIARFSDW 555
            .||.  .:|:|    .|::.:...|     |||:....|: ..|...|.:.:.:...|
Human   496 AAGAAEGVGVWSLEPEDLSAVTMER-----FEPQINAEES-EIRYSTWKKAVMKSMGW 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1271	NP_647763.1	GlpK	32..555	CDD:223628	152/576 (26%)
CG1271	NP_647763.1	FGGY_GK5_metazoa	32..552	CDD:212665	152/573 (27%)
GK	XP_011543793.1	FGGY_GK1-3_metazoa	11..547	CDD:212664	152/576 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820