DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1271 and GK5

DIOPT Version :9

Sequence 1:	NP_647763.1	Gene:	CG1271 / 38364	FlyBaseID:	FBgn0035392	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001034636.1	Gene:	GK5 / 256356	HGNCID:	28635	Length:	529	Species:	Homo sapiens

Alignment Length:	541	Identity:	213/541 - (39%)
Similarity:	314/541 - (58%)	Gaps:	27/541 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 QCAEESGPPDSPAFILALDVGTTCVRSFVLDEQCEVRGSAVDAVELLNPQPGYFEIEPESLWRKI 83
            |.|:|   |..|.|:|.||||::.:|..|.|....|.||:|..||.|.||.|:.||:|:.||.:.
Human    10 QRAQE---PRYPGFVLGLDVGSSVIRCHVYDRAARVCGSSVQKVENLYPQIGWVEIDPDVLWIQF 71

  Fly    84 VGVITQAVKNAQLTPPDITCLTISTQRCTFLTWDHRSGEYYHNFITWKDLRADELVDQWNASWTK 148
            |.||.:|||.|.:....|..|.|||||.||:||:.::|.::||||:|:||||.|||..||.|...
Human    72 VAVIKEAVKAAGIQMNQIVGLGISTQRATFITWNKKTGNHFHNFISWQDLRAVELVKSWNNSLLM 136

  Fly   149 SSMNWFSYALFLLTRQSRFLAGSVLQLMNGQVTPRLLFEIMNNKKLKQALMQKKARVELLDSWIL 213
            ...:.....|...||..|....|:......|.:.||::.:.|..::::|:.::......:|:|:|
Human   137 KIFHSSCRVLHFFTRSKRLFTASLFTFTTQQTSLRLVWILQNLTEVQKAVEEENCCFGTIDTWLL 201

  Fly   214 HKLRTGSSRDKDVEHITDVTSSTATGLYDPFTLSWSPLISWLFGINSKILPRVVDNGYKGFGHVH 278
            :||..||      .:.||.::::.|||:||:.:.||.:|:.|..|...:||.|.|..: .||.|.
Human   202 YKLTKGS------VYATDFSNASTTGLFDPYKMCWSGMITSLISIPLSLLPPVRDTSH-NFGSVD 259

  Fly   279 PTAFGPDWANTEIPIAASLSDQTAAIWGSQCFQKNDVKVTMGTGAFLNLVTGDRCQAVISGMYPL 343
            ...||     ..|||.|.::||.:|::|..|||..|||:|||||.||::.||:..|....|.|||
Human   260 EEIFG-----VPIPIVALVADQQSAMFGECCFQTGDVKLTMGTGTFLDINTGNSLQQTTGGFYPL 319

  Fly   344 VAWQFKKPTRQQGAVYCI-EGASHDFGTVVTWAQSCELFDSPANTSDIAQSVPDTNDVFFMPAFS 407
            :.|:..:      .|.|: |..:.|.||.:.|||..:||...|.|..:|:|:.|:..|.|:|:||
Human   320 IGWKIGQ------EVVCLAESNAGDTGTAIKWAQQLDLFTDAAETEKMAKSLEDSEGVCFVPSFS 378

  Fly   408 GLGPPVNDYRSASGFIGLTPSTTKAHMVRALLESIVFRLVQLIEAAEKETSQKLHMIRVDGGVSR 472
            ||..|:||..:.:.|:||.|||:|.|:|||:||||.||..||.|..:||....:..||.||||.:
Human   379 GLQAPLNDPWACASFMGLKPSTSKYHLVRAILESIAFRNKQLYEMMKKEIHIPVRKIRADGGVCK 443

  Fly   473 NDFVCQFLADLSRLRVERADNAESSIMGATFMAGINLGIWRDVNDLKRFRKVARVFEPRPK--EY 535
            |.||.|..:||....::|..:.:.|.:||..:||:.:|.|.|..:||:.|:...||:|:.|  ||
Human   444 NGFVMQMTSDLINENIDRPADIDMSCLGAASLAGLAVGFWTDKEELKKLRQSEVVFKPQKKCQEY 508

  Fly   536 ETIANRMDKWSRTIARFSDWY 556
            |.   .::.|::.:.|..:||
Human   509 EM---SLENWAKAVKRSMNWY 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1271	NP_647763.1	GlpK	32..555	CDD:223628	206/525 (39%)
CG1271	NP_647763.1	FGGY_GK5_metazoa	32..552	CDD:212665	205/522 (39%)
GK5	NP_001034636.1	GlpK	19..525	CDD:223628	206/526 (39%)
GK5	NP_001034636.1	FGGY_GK5_metazoa	20..522	CDD:212665	205/522 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143500
Domainoid	1	1.000	156	1.000	Domainoid score	I4201
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15141
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2056
Isobase	1	0.950	-	0	Normalized mean entropy	S2298
OMA	1	1.010	-	-		QHG56138
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0006572
OrthoInspector	1	1.000	-	-		oto91764
orthoMCL	1	0.900	-	-		OOG6_107542
Panther	1	1.100	-	-	LDO	PTHR10196
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4008
SonicParanoid	1	1.000	-	-		X5572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750