DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1271 and Gk5

DIOPT Version :9

Sequence 1:	NP_647763.1	Gene:	CG1271 / 38364	FlyBaseID:	FBgn0035392	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001355808.1	Gene:	Gk5 / 235533	MGIID:	2443336	Length:	534	Species:	Mus musculus

Alignment Length:	540	Identity:	211/540 - (39%)
Similarity:	308/540 - (57%)	Gaps:	24/540 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 QCAEESGPPDSPAFILALDVGTTCVRSFVLDEQCEVRGSAVDAVELLNPQPGYFEIEPESLWRKI 83
            :.:..:.||.  .|:|.||||:|.:|..|.|:...||||:...||.:.||||:.||:|:|||.:.
Mouse    14 ELSASASPPS--RFVLGLDVGSTVIRCHVYDQTARVRGSSAQKVENVYPQPGWVEIDPDSLWAQF 76

  Fly    84 VGVITQAVKNAQLTPPDITCLTISTQRCTFLTWDHRSGEYYHNFITWKDLRADELVDQWNASWTK 148
            |.||..|||.|.:....|..|.|||||.||:||:.::|.::||||:|:||||.|||..||.|...
Mouse    77 VAVIKDAVKAAGVQMNQIVGLGISTQRATFITWNKKTGHHFHNFISWQDLRAAELVKSWNNSLIM 141

  Fly   149 SSMNWFSYALFLLTRQSRFLAGSVLQLMNGQVTPRLLFEIMNNKKLKQALMQKKARVELLDSWIL 213
            ..::..:..|...:|....|..|.........|.||.:.:.|..::|:|:.:.......:|:|:|
Mouse   142 KLLHGATRVLHFFSRSKVMLTVSRFNFSTQHATLRLTWILQNLSEVKRAVEEDNCCFGTIDTWLL 206

  Fly   214 HKLRTGSSRDKDVEHITDVTSSTATGLYDPFTLSWSPLISWLFGINSKILPRVVDNGYKGFGHVH 278
            :||..|||      :.||.::::.||.:||:.:.||.||:.:..|...|||.|.|..| .||.|.
Mouse   207 YKLTKGSS------YATDYSNASTTGFFDPYAMRWSRLITTMVSIPLSILPPVKDTSY-NFGSVD 264

  Fly   279 PTAFGPDWANTEIPIAASLSDQTAAIWGSQCFQKNDVKVTMGTGAFLNLVTGDRCQAVISGMYPL 343
            ...||     ..||:.|.:.||.:|::|..||:..|||:|||||.||::.||...|.|..|.|||
Mouse   265 EKIFG-----VPIPVVALVGDQQSAMFGECCFETGDVKLTMGTGTFLDINTGKNLQHVNGGFYPL 324

  Fly   344 VAWQFKKPTRQQGAVYCIEGASHDFGTVVTWAQSCELFDSPANTSDIAQSVPDTNDVFFMPAFSG 408
            :.|:.     .|..|...||.:.|.||.:.|||..:||...|.|..:|.|:.|:..|:|:|:|||
Mouse   325 IGWKI-----GQELVCLAEGNAGDTGTAIMWAQKLDLFTDAAETEKMALSLEDSEGVYFVPSFSG 384

  Fly   409 LGPPVNDYRSASGFIGLTPSTTKAHMVRALLESIVFRLVQLIEAAEKETSQKLHMIRVDGGVSRN 473
            |..|:||..:.:.|:||..||.|.|:|||:||||.||..||.:..::|....:..||.||||..|
Mouse   385 LQAPLNDPCACASFMGLKHSTNKYHLVRAILESIAFRNKQLYDMLQREIQIPVTNIRADGGVCNN 449

  Fly   474 DFVCQFLADLSRLRVERADNAESSIMGATFMAGINLGIWRDVNDLKRFRKVARVFEPRPK--EYE 536
            .||.|..:||...:::|..:.:.|.:||..:||:.:|.|.|..:|::.|:...||:|:.|  |||
Mouse   450 AFVMQMTSDLINEKIDRPAHFDMSCLGAASLAGLAVGFWADKEELQKLRQSEMVFKPQKKWQEYE 514

  Fly   537 TIANRMDKWSRTIARFSDWY 556
            .   .|:.|.:.:.|..:||
Mouse   515 V---NMENWVKAVKRSMNWY 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1271	NP_647763.1	GlpK	32..555	CDD:223628	207/524 (40%)
CG1271	NP_647763.1	FGGY_GK5_metazoa	32..552	CDD:212665	206/521 (40%)
Gk5	NP_001355808.1	FGGY_GK5_metazoa	25..527	CDD:212665	206/521 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833657
Domainoid	1	1.000	151	1.000	Domainoid score	I4348
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15141
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2029
Isobase	1	0.950	-	0	Normalized mean entropy	S2298
OMA	1	1.010	-	-		QHG56138
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0006572
OrthoInspector	1	1.000	-	-		oto95344
orthoMCL	1	0.900	-	-		OOG6_107542
Panther	1	1.100	-	-	LDO	PTHR10196
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4008
SonicParanoid	1	1.000	-	-		X5572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750