DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1271 and R11F4.1

DIOPT Version :9

Sequence 1:	NP_647763.1	Gene:	CG1271 / 38364	FlyBaseID:	FBgn0035392	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_494721.1	Gene:	R11F4.1 / 173747	WormBaseID:	WBGene00020007	Length:	502	Species:	Caenorhabditis elegans

Alignment Length:	545	Identity:	143/545 - (26%)
Similarity:	241/545 - (44%)	Gaps:	70/545 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ILALDVGTTCVRSFVLD---------EQCEVRGSAVDAVELLNPQPGYFEIEPESLWRKIVGVIT 88
            :.|:|.||:..|..|.:         .|.|||        .|.|..|:.|::|..|:..:|..|:
Worm     4 LAAIDQGTSSSRFLVFEADTGELVTSHQIEVR--------QLFPHGGWVEMDPMELYDTVVSCIS 60

  Fly    89 QAV---KNAQLTPPDITCLTISTQRCTFLTWDHRSGEYYHNFITWKDLRADELVDQWNASWTKSS 150
            :.:   :|..::..:|..:.::.||.|.:.||..:|:..:|.|.|.|.|...|.|:..:.....|
Worm    61 KTIEKLENLGISADEIKSVGVANQRETSIVWDKETGKPLYNAIVWLDTRTSSLADEAISRTASKS 125

  Fly   151 MNWFSYALFLLTRQSRFLAGSVLQLMNGQVTPRLLFEIMNNKKLKQALMQKKARVELLDSWILHK 215
            .:.|           |...|..:......:..:.||:  |..::|:|..........:|:|::.|
Worm   126 KDEF-----------RAKTGLPIHPYFSALKLKWLFQ--NVPEVKKAYADGNLMFGTVDTWLIWK 177

  Fly   216 LRTGSSRDKDVEHITDVTSSTATGLYDPFTLSWSPLISWLFGINSKILPRVVDNGYKGFGHVHPT 280
            | ||:       ::|||::::.|.|.|.....||..:...|.:..:|||.:..:. :.:||...
Worm   178 L-TGA-------YVTDVSNASRTLLLDLHKRKWSTQLCEFFDLPIEILPEIRSSA-EVYGHFDK- 232

  Fly   281 AFGPDWANTEIPIAASLSDQTAAIWGSQCFQKNDVKVTMGTGAFLNLVTGDRCQAVISGMYPLVA 345
              ||   ...:|::..|.||.||:.|.||......|.|.|||.|:....|.|.....:|:...|.
Worm   233 --GP---LEGVPLSGCLGDQQAAMVGHQCLNAGQTKNTYGTGTFMLCNIGTRPIISKNGLLTTVG 292

  Fly   346 WQFKKPTRQQGA----VYCIEGASHDFGTVVTWAQSCELFDSPANTSD-IAQSVPDTNDVFFMPA 405
            :||       ||    ||.:||:....|.||.:.:....|.|.|...: :.:||.||:..:|:|:
Worm   293 FQF-------GADSPVVYALEGSGSIGGNVVRFLRDNFKFISDAKEMEGLCRSVEDTSGAYFVPS 350

  Fly   406 FSGLGPPVNDYRSASGFIGLTPSTTKAHMVRALLESIVFRLVQLIEAAEK--ETSQKLHMIRVDG 468
            |:||..|..|..:....:|||..|.:.|:..|.|.::.|:..::|.|.|:  |...|:..::|||
Worm   351 FTGLYTPYWDSTARGTILGLTQVTQREHICLAALRAVAFQSAEMIAAVEQDLEGGTKVTTLKVDG 415

  Fly   469 GVSRNDFVCQFLADLSRLRVERADNAESSIMGATFMAGINLGIWRDVNDLKRFRKVA---RVFEP 530
            |:..|....:..||:....:......|.|..||. :||   ||......|..|.:.:   ..:.|
Worm   416 GMIANKLFNEIQADIMGRDIVTPKITEISGWGAA-VAG---GIGAQQISLDEFLQQSSEDNRYTP 476

  Fly   531 RPKEYETIANRMDKWSRTIARFSDW 555
            : |:....:..:.:|...:.|...|
Worm   477 Q-KDDNWRSAELARWKEAVKRSCGW 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1271	NP_647763.1	GlpK	32..555	CDD:223628	142/543 (26%)
CG1271	NP_647763.1	FGGY_GK5_metazoa	32..552	CDD:212665	141/540 (26%)
R11F4.1	NP_494721.1	glycerol_kin	3..500	CDD:273549	142/543 (26%)
R11F4.1	NP_494721.1	FGGY_GK	3..491	CDD:198347	140/534 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820