DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1271 and Gykl1

DIOPT Version :9

Sequence 1:	NP_647763.1	Gene:	CG1271 / 38364	FlyBaseID:	FBgn0035392	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_034423.2	Gene:	Gykl1 / 14625	MGIID:	891990	Length:	549	Species:	Mus musculus

Alignment Length:	548	Identity:	152/548 - (27%)
Similarity:	254/548 - (46%)	Gaps:	57/548 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DSPAFIL-----ALDVGTTCVRSFVLDEQ-----CEVRGSAVDAVELLN--PQPGYFEIEPESLW 80
            ::|..:|     |:|.||:..|..|.:.|     |.      ..||:..  |:.|:.|.:|:::.
Mouse     3 EAPKAVLGPLVGAVDQGTSSTRFLVFNPQTAELLCH------HQVEIAQEFPKEGWVEQDPKAIL 61

  Fly    81 RKIVGVITQAVKNAQLTPPDIT---CLTISTQRCTFLTWDHRSGEYYHNFITWKDLRADELVDQW 142
            :.:...|.:|.:.......||:   .:.::.||.|.:.||..:||..:|.:.|.|||....|:
Mouse    62 QSVYECIEKACEKLGQQSIDISNIKAIGVTNQRETTIVWDKFTGEPLYNAVVWLDLRTQSTVE-- 124

  Fly   143 NASWTKSSMNWFSYALFLLTRQSRFLAGSVLQLMNGQVTPRLLFEIMNNKKLKQALMQKKARVEL 207
            |.|.:.|..|.|......|...:.|.|            .:|.:.|.|.:|:::|:...:|....
Mouse   125 NLSKSISVSNNFVKNKTGLPISTYFSA------------VKLHWLIENVRKVQKAIEDGRAIFGT 177

  Fly   208 LDSWILHKLRTGSSRDKDVEHITDVTSSTATGLYDPFTLSWSPLISWLFGINSKILPRVVDNGYK 272
            :|||::..:..|.:..   .|.|||::::.|.|::..:|.|...:...|||...||||:..:. :
Mouse   178 VDSWLIWCMTGGINGG---VHCTDVSNASRTMLFNIHSLQWDEELCDFFGIPMTILPRIRSSS-E 238

  Fly   273 GFGHVHPTAFGPDWANTEIPIAASLSDQTAAIWGSQCFQKNDVKVTMGTGAFLNLVTGDRCQAVI 337
            .:|.|.....      ..:||:..|.||:||:.|..|.|....|.|.|||.||...||.:|....
Mouse   239 IYGLVKSGVL------EGVPISGCLGDQSAALVGQLCLQDGQAKSTYGTGCFLLCNTGQKCVNSE 297

  Fly   338 SGMYPLVAWQFKKPTRQQGAVYCIEGASHDFGTVVTWAQ-SCELFDSPANTSDIAQSVPDTNDVF 401
            .|:...||:|.   .||:...|.:||:....|.||:|.: :.::..|.:....:|:....:...:
Mouse   298 HGLLTTVAYQL---GRQEPVYYALEGSVAIAGAVVSWIKNNLQIIQSSSEIEKLAEVAGTSYGCY 359

  Fly   402 FMPAFSGLGPPVNDYRSASGFI-GLTPSTTKAHMVRALLESIVFRLVQLIEAAEKETSQKLHMIR 465
            |:||||||..|..| .||.|.| |||..|.|.|:..|.||::.|:..::::|...:....|..::
Mouse   360 FVPAFSGLYAPYWD-PSARGIICGLTQFTNKFHIAFAALEAVCFQTREILDAMNSDCGIPLTHLQ 423

  Fly   466 VDGGVSRNDFVCQFLADLSRLRVERADNAESSIMGATFMAGI--NLGIWR-DVNDLKRFRKVARV 527
            ||||::.|..:.|..||:..:.|.:....|::.:|....||.  .:.:|. |..||...:  ...
Mouse   424 VDGGMTANRVLMQLQADILCIPVMKPFMPETTALGVAMAAGAAEGVSVWSLDPKDLSSVQ--MEK 486

  Fly   528 FEPRPKEYETIANRMDKWSRTIARFSDW 555
            |||:....|: ..|...|.:.:.:...|
Mouse   487 FEPQINVEES-EGRYATWKKAVLKSMGW 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1271	NP_647763.1	GlpK	32..555	CDD:223628	150/542 (28%)
CG1271	NP_647763.1	FGGY_GK5_metazoa	32..552	CDD:212665	150/539 (28%)
Gykl1	NP_034423.2	glycerol_kin	11..513	CDD:273549	149/538 (28%)
Gykl1	NP_034423.2	FGGY_GK1-3_metazoa	11..513	CDD:212664	149/538 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820