DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32485 and TTPA

DIOPT Version :9

Sequence 1:	NP_728794.1	Gene:	CG32485 / 38363	FlyBaseID:	FBgn0052485	Length:	222	Species:	Drosophila melanogaster
Sequence 2:	NP_000361.1	Gene:	TTPA / 7274	HGNCID:	12404	Length:	278	Species:	Homo sapiens

Alignment Length:	217	Identity:	49/217 - (22%)
Similarity:	83/217 - (38%)	Gaps:	51/217 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DFSLRRYLRAFKTTDDAFQAILKT-NKWRETYGVDKLSEMDRSQLDKKARLLRHRDCIGRPVIYI 98
            |..|.|:|||.....|....:||. .|||        :|......|     |..|..||    .:
Human    49 DSFLLRFLRARDFDLDLAWRLLKNYYKWR--------AECPEISAD-----LHPRSIIG----LL 96

  Fly    99 PAKNHSSERDIDEL-TRFIVYNLEEACKKCFEE--------VTDRLCI------------VFDLA 142
            .|..|...|..|.. ::.::|.:.....|.|..        :|..|.:            :|||.
Human    97 KAGYHGVLRSRDPTGSKVLIYRIAHWDPKVFTAYDVFRVSLITSELIVQEVETQRNGIKAIFDLE 161

  Fly   143 --EFSTSCMDYQL----VQNLIWLLGKHFPERLGVCLIINSPGLFSTIWPAIRVLLDDNTAKKVK 201
              :||.:   :|:    .:.:..:|...||.::....:||.|.:|..::..|:..|.:...:::.
Human   162 GWQFSHA---FQITPSVAKKIAAVLTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKERIH 223

  Fly   202 FVAD--EAELCQYLIPDILPTD 221
            ...:  :..|.|: .|||||.:
Human   224 MHGNNYKQSLLQH-FPDILPLE 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32485	NP_728794.1	CRAL_TRIO	85..219	CDD:279044	33/162 (20%)
TTPA	NP_000361.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		CRAL_TRIO_N	<40..73	CDD:215024	9/23 (39%)
		CRAL_TRIO	99..248	CDD:395525	30/150 (20%)
		Phosphatidylinositol 3,4-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:Q8BWP5	190..192		0/1 (0%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:Q8BWP5	208..211		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810