DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scramb2 and Plscr3

DIOPT Version :9

Sequence 1:	NP_647761.1	Gene:	scramb2 / 38362	FlyBaseID:	FBgn0035390	Length:	263	Species:	Drosophila melanogaster
Sequence 2:	NP_001161969.1	Gene:	Plscr3 / 70310	MGIID:	1917560	Length:	296	Species:	Mus musculus

Alignment Length:	257	Identity:	105/257 - (40%)
Similarity:	149/257 - (57%)	Gaps:	13/257 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LPQNAPQDENG-AVVLQPQAANVGNNANGPENWMSIP-VGMPNCPQGLEYLTALDQLLVSQKIEK 72
            :|...|....| |:...|     |..|.||    ..| |.:|..|.|||:|..:||:|:.||.|:
Mouse    39 VPTQVPAPAPGFALFPSP-----GPVAPGP----PAPFVPLPGVPPGLEFLVQIDQILIHQKAER 94

  Fly    73 LELLTGFETKNRFKVKNSLGQNVYFAYEESDCCTRNMLGRSRPFEMKILDNFQNEVLHLYRPFKC 137
            :|...|:||.|.:::::..||.:..|.|||:||.|...|..|||.:::.|....|||.|.||..|
Mouse    95 VETFLGWETCNMYELRSGTGQQLGQAAEESNCCARLCCGARRPFRIRLADPGDREVLRLLRPLHC 159

  Fly   138 DILCCFPSCMNAVEVSAPPGQVIGSVEQVCTFMRPKFNIKNTCGDTVLQIEGPVCPCKCFSDTNF 202
            ...|| |..:..:||.||||..||.|.|......|||:|.:.....||::.||...|.|.:||||
Mouse   160 GCSCC-PCGLQEMEVQAPPGTTIGHVLQTWHPFLPKFSILDADRQPVLRVVGPCWTCGCGTDTNF 223

  Fly   203 KVLSAN-NEEIGKISKQWSGLGRELFTDADYFSVTFPLNLDVRMKALIFAALFLIDAVYYEQ 263
            :|.:.: :..:|:|||||.||.||..||||.|.:.||::|||::||::..|.||||.:::|:
Mouse   224 EVKTKDESRSVGRISKQWGGLLREALTDADDFGLQFPVDLDVKVKAVLLGATFLIDYMFFEK 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scramb2	NP_647761.1	Scramblase	42..263	CDD:252175	95/222 (43%)
Plscr3	NP_001161969.1	Proline-rich domain (PRD). /evidence=ECO:0000250\|UniProtKB:O15162	1..58		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45		1/5 (20%)
		SH3-binding 1. /evidence=ECO:0000255	7..15
		PPxY motif. /evidence=ECO:0000255	15..18
		SH3-binding 2. /evidence=ECO:0000255	21..27
		SH3-binding 3. /evidence=ECO:0000255	66..71		2/4 (50%)
		Scramblase	69..285	CDD:252175	93/216 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0621
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23219
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1015148at2759
OrthoFinder	1	1.000	-	-		FOG0000205
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X164
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.880