Protein Alignment scramb2 and PLSCR3

DIOPT Version :10

• Sequence 1: NP_647761.1
• Gene: scramb2 / 38362
• FlyBaseID: FBgn0035390
• Length: 263
• Species: Drosophila melanogaster
• Sequence 2: NP_065093.2
• Gene: PLSCR3 / 57048
• HGNCID: 16495
• Length: 295
• Species: Homo sapiens
• Alignment Length: 255
• Identity: 105/255 - (41%)
• Similarity: 149/255 - (58%)
• Gaps: 9/255 - (3%)

  Fly    10 LPQNAPQDENGAVVLQPQAANVGNNANGPENWMSIPVGMPNCPQGLEYLTALDQLLVSQKIEKLE 74
            :|...|....| ..|.|....|...:..|    .:|  :|..|.|||:|..:||:|:.||.|::|
Human    38 VPAQVPAPAPG-FALFPSPGPVALGSAAP----FLP--LPGVPSGLEFLVQIDQILIHQKAERVE 95

  Fly    75 LLTGFETKNRFKVKNSLGQNVYFAYEESDCCTRNMLGRSRPFEMKILDNFQNEVLHLYRPFKCDI 139
            ...|:||.||:::::..||.:..|.|||:||.|...|..||..:::.|....|||.|.||..|..
Human    96 TFLGWETCNRYELRSGAGQPLGQAAEESNCCARLCCGARRPLRVRLADPGDREVLRLLRPLHCGC 160

  Fly   140 LCCFPSCMNAVEVSAPPGQVIGSVEQVCTFMRPKFNIKNTCGDTVLQIEGPVCPCKCFSDTNFKV 204
            .|| |..:..:||.||||..||.|.|......|||:|::....|||::.||...|.|.:||||:|
Human   161 SCC-PCGLQEMEVQAPPGTTIGHVLQTWHPFLPKFSIQDADRQTVLRVVGPCWTCGCGTDTNFEV 224

  Fly   205 LSAN-NEEIGKISKQWSGLGRELFTDADYFSVTFPLNLDVRMKALIFAALFLIDAVYYEQ 263
            .:.: :..:|:|||||.||.||..||||.|.:.|||:||||:||::..|.||||.:::|:
Human   225 KTRDESRSVGRISKQWGGLVREALTDADDFGLQFPLDLDVRVKAVLLGATFLIDYMFFEK 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scramb2	NP_647761.1	Scramblase	42..263	CDD:252175	97/221 (44%)
PLSCR3	NP_065093.2	Proline-rich domain (PRD). /evidence=ECO:0000250|UniProtKB:O15162	1..57		5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		0/1 (0%)
		SH3-binding 1. /evidence=ECO:0000255	7..15
		PPxY motif. /evidence=ECO:0000255	15..18
		SH3-binding 2. /evidence=ECO:0000255	21..27
		PRK05641	<31..>71	CDD:235540	8/39 (21%)
		Scramblase	62..284	CDD:252175	98/228 (43%)
		SH3-binding 3. /evidence=ECO:0000255	65..70		2/10 (20%)