Protein Alignment scramb2 and PLSCR2

DIOPT Version :10

• Sequence 1: NP_647761.1
• Gene: scramb2 / 38362
• FlyBaseID: FBgn0035390
• Length: 263
• Species: Drosophila melanogaster
• Sequence 2: NP_001186907.1
• Gene: PLSCR2 / 57047
• HGNCID: 16494
• Length: 297
• Species: Homo sapiens
• Alignment Length: 247
• Identity: 111/247 - (44%)
• Similarity: 153/247 - (61%)
• Gaps: 8/247 - (3%)

  Fly    24 LQPQAANVG----NNANGPEN--WMSIPVGMPNCPQGLEYLTALDQLLVSQKIEKLELLTGFETK 82
            |.|.|...|    |....||.  ||..|....|||.|||||:.:|.:|:.|:||.||:|..||:.
Human    50 LVPPAGTAGIPVQNQPGRPEGVPWMPAPPPPLNCPPGLEYLSQIDMILIHQQIELLEVLFSFESS 114

  Fly    83 NRFKVKNSLGQNVYFAYEESDCCTRNMLGRSRPFEMKILDNFQNEVLHLYRPFKCDILCCFPSCM 147
            |.:::|||.||.:|||.|:::.|.||..||||||.::|.||...||:.|.||.:|:..|| |.|:
Human   115 NMYEIKNSFGQRIYFAAEDTNFCIRNCCGRSRPFTLRITDNVGREVITLERPLRCNCCCC-PCCL 178

  Fly   148 NAVEVSAPPGQVIGSVEQVCTFMRPKFNIKNTCGDTVLQIEGPVCPCKCFSDTNFKVLSANNE-E 211
            ..:|:.||||..:|.|.|.......||.|||...:.||:|.||...|.|.:..:|::.|.:.: .
Human   179 QEIEIQAPPGVPVGYVTQTWHPCLTKFTIKNQKREDVLKISGPCIVCSCIAGVDFEITSLDEQIV 243

  Fly   212 IGKISKQWSGLGRELFTDADYFSVTFPLNLDVRMKALIFAALFLIDAVYYEQ 263
            :|:|||.|||..||.|||||.|.:.||.:|||:|||::..|.||||.:::|:
Human   244 VGRISKHWSGFLREAFTDADNFGIQFPRDLDVKMKAVMIGACFLIDYMFFER 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scramb2	NP_647761.1	Scramblase	42..263	CDD:252175	102/221 (46%)
PLSCR2	NP_001186907.1	Proline-rich domain (PRD). /evidence=ECO:0000250|UniProtKB:O15162	1..72		7/21 (33%)
		Scramblase	86..295	CDD:252175	97/209 (46%)