DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scramb2 and Plscr4

DIOPT Version :9

Sequence 1:	NP_647761.1	Gene:	scramb2 / 38362	FlyBaseID:	FBgn0035390	Length:	263	Species:	Drosophila melanogaster
Sequence 2:	NP_848826.1	Gene:	Plscr4 / 235527	MGIID:	2143267	Length:	326	Species:	Mus musculus

Alignment Length:	256	Identity:	98/256 - (38%)
Similarity:	145/256 - (56%)	Gaps:	4/256 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LPQNAPQDENGAVVLQPQAANVGNNANGPENWMSIPVGMPNCPQGLEYLTALDQLLVSQKIEKLE 74
            :|...|......:..||....| .|...|..||:.|..:||||.|||||..||.:.|.|.:|.||
Mouse    65 IPLYHPTGGTHPIQYQPGKYPV-TNQPAPIMWMAGPAPVPNCPPGLEYLAQLDNIHVLQHVEPLE 128

  Fly    75 LLTGFETKNRFKVKNSLGQNVYFAYEESDCCTRNMLGRSRPFEMKILDNFQNEVLHLYRPFKCDI 139
            |:|.|||.||:.:||::.|.||...|::|..|||.....|||.:::.|....|::.:.|||:|..
Mouse   129 LMTRFETNNRYDIKNNIDQMVYIVTEDTDDFTRNAYRNLRPFVLRVTDCLGREIMTMQRPFRCTC 193

  Fly   140 LC-CFPSCMNAVEVSAPPGQVIGSVEQVCTFMRPKFNIKNTCGDTVLQIEGPVCPCKCFSDTNFK 203
            .| |.|.....:||..|||..||.|.:.....|..::|:|...::::::.||.....|.||:.|:
Mouse   194 CCFCCPCARQELEVQCPPGVTIGFVAEHWNLCRASYSIQNEKKESMMRVRGPCATYGCGSDSVFE 258

  Fly   204 VLSANN-EEIGKISKQWSGLGRELFTDADYFSVTFPLNLDVRMKALIFAALFLIDAVYYEQ 263
            :.|.:. ..||.|.::|:|. .....:||:|.:.|||.|||:|||:||.:.||||.:|:|:
Mouse   259 INSLDGVSNIGSIIRKWNGF-LSTMVNADHFEIRFPLALDVKMKAMIFGSCFLIDFMYFER 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scramb2	NP_647761.1	Scramblase	42..263	CDD:252175	89/222 (40%)
Plscr4	NP_848826.1	Proline-rich domain (PRD). /evidence=ECO:0000250	1..94		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		SH3-binding 1. /evidence=ECO:0000255	18..25
		DAZAP2	27..>113	CDD:287943	18/48 (38%)
		PPxY motif. /evidence=ECO:0000255	30..33
		SH3-binding 2. /evidence=ECO:0000255	41..49
		SH3-binding 3. /evidence=ECO:0000255	94..102		3/7 (43%)
		Scramblase	96..318	CDD:252175	89/222 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0621
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1015148at2759
OrthoFinder	1	1.000	-	-		FOG0000205
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X164
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.880