DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2162 and R3hcc1l

DIOPT Version :9

Sequence 1:	NP_001163332.2	Gene:	CG2162 / 38360	FlyBaseID:	FBgn0035388	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_803415.1	Gene:	R3hcc1l / 52013	MGIID:	1196316	Length:	775	Species:	Mus musculus

Alignment Length:	726	Identity:	193/726 - (26%)
Similarity:	298/726 - (41%)	Gaps:	184/726 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 ENRKQQQQREKDR------------EREAARSWRSNNNSHYHTNGRSSSASRRSATELCKM---- 128
            |.::...|..|||            ::.|..|..:::..|.|   |:..|...|:..|.::
Mouse    83 EGKRSASQLRKDRCPQKQNKEKACSKKGAEESTEASSQEHQH---RAPDAGIVSSIPLQRLFKPK 144

  Fly   129 ----------GVKKHISETPLSKSNSVDLYRPPA--LRN------------NSNNNNSSSEEA-- 167
                      |...|...:|...|:.|...:.|:  .:|            |.|..:|...||
Mouse   145 DMDCWEVQTAGATGHWRVSPSQSSSEVSAAQVPSRPFQNVELCDFSGETFVNRNLESSIVTEAKV 209

  Fly   168 ----AAVNEAITTPLAA-GTA------TTASTSPTSKESP-----NREADASAAAAAAATRRERR 216
                :...:.:||.|.. |.|      :.:.|:|:|.|:|     :...|.|..:....
Mouse   210 PELVSQFPQVVTTLLKPDGMAMPVTLSSDSETAPSSLETPDGMSKHSPGDISVVSVPGG------ 268

  Fly   217 PDRAV---YVPRARRSQTT-----------------------------------------PPTTT 237
            ||..|   :|.....|:.|                                         |..|.
Mouse   269 PDEDVDSTFVDFEVESEGTVNSTESVLGQKGVDSILETVDNVSLKMAVVSKLESTNGTIDPAVTR 333

  Fly   238 TTTTAAAATAVATTSPPAAAAVVAATITTAPDSPPVADTQPSKA----------DDV------NG 286
            ...:.::|..:...|.|:..||:...|.|......|.|: .|||          |.|      .|
Mouse   334 ECESDSSADELCVKSEPSDTAVLVHEIDTDDGFRNVCDS-TSKACMVDIAGTACDPVTEGSSCTG 397

  Fly   287 QPPSKSKKSKSHRERRERAKKTTTATTADNATVLVISASENDTQSNEEHRPAKPADCDKEIMSGA 351
            ......:.|.:.|...:..:.:......|.|      .||||:::.......  :|...|.::..
Mouse   398 AVGESGESSGNMRNFSDYIEMSADVAPLDRA------KSENDSENISSLSAC--SDIYAESIASG 454

  Fly   352 QRTKPGNGNKSASNGKSQASPPLR------------------------IEDVVAARSTNGEEPAK 392
            .....|...:|.|:|.|  |.|::                        :|..:.:.....||..:
Mouse   455 FTESTGKLIESVSDGAS--SLPIKKTADSNIATCLDSELSMSDASDVLLESALGSDLDTTEEMTE 517

  Fly   393 CDNDVRELQR-ASKEINRSNRRIMKQTFNSDVLEIPEKIETSATKAIPTSPQASATAKPPVDSTT 456
            ..:|::..:. .:||.:.|...:...:|:...:|....::|:.|..|    |.|:..
Mouse   518 ALHDLKTAEEFKTKEEDYSESVVCGISFSDSSVETSVDLKTTDTSHI----QGSSAV-------- 570

  Fly   457 EDDDEEDEDDWEKMFDESGDCLDPKLLQELTESVGKCK-IELPKMDYTVFHIKQQLLNEEEFPHV 520
                   |:.||.||::.|||:||:||.||:.:|...| |:.|:.||....:....|:|.|||||
Mouse   571 -------EESWESMFNDDGDCVDPRLLLELSGNVKNRKSIQEPRFDYYSHELPDIDLSECEFPHV 628

  Fly   521 LEVSNFPVEFKTPDLLMLFAQYRGSGFDIKWVDDTHALAVFSSSRIAAEVLTMGHPFVKLKPLAE 585
            :|:.:||.||:|.|||.:|..|:..|||||||||||||.||:|...|.:.|...|..||::||::
Mouse   629 IEIYDFPQEFRTEDLLRIFCSYQKKGFDIKWVDDTHALGVFASPITARDALGTKHTMVKIRPLSQ 693

  Fly   586 ATLESRLKAKKAGAVSMQPYRQRPETCTALARRLVSGALGVKLPTAPQERENERRVLREAKERKL 650
            ||..::.|| :|.|..:||.::||||..|||||||..||||:...:..|||.|.|.|:||:|||.
Mouse   694 ATRAAKAKA-RACAEFLQPAKERPETSAALARRLVISALGVRSKQSKTEREAELRKLQEARERKR 757

  Fly   651 LAAKQRDEVWE 661
            |.||||:::||
Mouse   758 LEAKQREDIWE 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2162	NP_001163332.2	R3H	6..70	CDD:294210
CG2162	NP_001163332.2	RRM_SF	519..583	CDD:302621	34/63 (54%)
R3hcc1l	NP_803415.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..127		10/46 (22%)
		EJC-binding motif, may mediate interaction with the EJC. /evidence=ECO:0000250	7..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..262		6/26 (23%)
		RRM_PARN	627..691	CDD:240874	34/63 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..775		9/14 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836918
Domainoid	1	1.000	224	1.000	Domainoid score	I2538
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3494
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363445at33208
OrthoFinder	1	1.000	-	-		FOG0002567
OrthoInspector	1	1.000	-	-		oto93852
orthoMCL	1	0.900	-	-		OOG6_106213
Panther	1	1.100	-	-	O	PTHR21678
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3424
SonicParanoid	1	1.000	-	-		X4368
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.020