DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2162 and F09C8.2

DIOPT Version :9

Sequence 1:	NP_001163332.2	Gene:	CG2162 / 38360	FlyBaseID:	FBgn0035388	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_510635.2	Gene:	F09C8.2 / 181690	WormBaseID:	WBGene00008622	Length:	762	Species:	Caenorhabditis elegans

Alignment Length:	744	Identity:	152/744 - (20%)
Similarity:	282/744 - (37%)	Gaps:	191/744 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DIELFVKKRLNRGVLLFPPVGNYRRYLIHQTCEKYRQQYDL---FTFSVGQGPQR---RTVLCF- 69
            |.||:  :.||...|  ||...:  :.:||..::.:|...:   ....:.|.||.   .:.:|:
Worm   116 DEELY--QALNMSPL--PPTATF--HALHQQQQQQQQHQSMKQQHAMHLQQQPQTDYLSSEVCYP 174

  Fly    70 RNQLLDPSGF---------------ENRKQQQQREKDRER---EAARSWRSNNNSHYHTNGRSSS 116
            .....:|||:               :.:..|...:.|.|.   |..|....:.....|:...::|
Worm   175 STSSYEPSGYNESGYCPQNSTILPDDPQNYQHGNDGDDEESFGEPERYEPMSPTFSIHSFAPTTS 239

  Fly   117 ASRRSATELCKMGVKKHISETPLSKSNSVDLYRPPALRNNSNNNNSSSEEAAAVNEAITTPLAAG 181
            .:...|.:|....:..|........|:.:|::......:::..|:.|        ::..|...:.
Worm   240 TNTAEAEDLEVELINNHKPTPRYQLSDDIDIFLHTGTTDDTEYNDDS--------DSRPTTTFSH 296

  Fly   182 TATTASTSPTSKESPNREADASAAAAAAATRRERRPDRA-VYVPRARRS----QTT-------PP 234
            .:|.|.|.|.|:.:   .|....|||......:::|..: :..|.::.|    |||       .|
Worm   297 RSTKAPTPPASRPA---YAQKFTAAAQNLKPEQQQPTTSDITSPISKTSPLFLQTTGQDPAGFTP 358

  Fly   235 TTTTTTTAAAATAVATT--SPPAAAAVVAATITTAPDSPP----VADTQPSKADDVNGQPPSKSK 293
            ..|..:.|.....::..  :||..|..::| ....|..||    ..:.|..:.:.|..|||
Worm   359 LLTPNSDALLQKKLSEVVHNPPQRAIGLSA-FPAFPQQPPHLTRFQENQRYEGNFVEYQPP---- 418

  Fly   294 KSKSHRERRERAKK-------TTTATTADN-----------------------ATVLV-ISASEN 327
            ..:.|::::.:|.:       ..|....|:                       .||.| :|..|.
Worm   419 PPQQHQQQQPQAPEGFYPPISLNTRYDYDSDRDILPLLLDTFQPLPAPPQIPPVTVSVPVSVPEL 483

  Fly   328 DTQSNEEHRPAK--------PADCDKEIMSGAQRTKPGNGNKSASNGKSQASPPLRIEDVVAARS 384
            .|.:.:..:|||        |...|:|:.|.:|:                    |.: ||::...
Worm   484 LTSTKKPSQPAKVPAAPIKAPRLSDQELESESQK--------------------LAL-DVISNLF 527

  Fly   385 TNGEEPAKCDNDVRELQRASKEINRSNRRIMKQTFNSDVLEIPEKIETSATKAIPTSPQASATAK 449
            :|.:|         .:.||: .::...:.:.:..|.:|    ||.:|            .:.:::
Worm   528 SNKKE---------IIDRAA-VLSAPKKPVARNLFCND----PESLE------------KAKSSE 566

  Fly   450 PPVDSTTEDDDEEDEDD----WEKMFDESGDCLDPKLLQELTESVGKCKIELP----KMDY-TVF 505
            |...|..:|.:..|:||    .|.:..      |.|..::..:|:.|..   |    ..|: |.|
Worm   567 PLTMSVLDDWETADDDDLTVRMENLLK------DKKKEEKKAQSMSKAP---PPPQRNSDWDTAF 622

  Fly   506 HIKQQLLNEEEFPHVLEVSNFPVEFKTPDLLMLFAQYRGSGFDIK--WVDDTHALAVFSSSRIAA 568
                       ..||||:...| ::|..:.::...:..|:| |.|  |::.....|||.|...|.
Worm   623 -----------LQHVLEIYGVP-DYKMQEDVVKAMETIGNG-DCKVMWMERKVVFAVFESVNRAK 674

  Fly   569 EVLTMG-HPFVKLKPLAEATLESRLKAKKAGAVSMQPYRQRPETCTALARRLVSGALGVKLPTAP 632
            ..||:. |.:::.:.||::....:..| |..|.|:...:::.:|...:|||:|..|||.|...:.
Worm   675 NCLTLSKHDWLRFRSLADSPKVVQDSA-KTNAASLGILKKKQQTTATVARRMVENALGKKATVST 738

  Fly   633 QERENERRVLREAKERKLLAAKQRDEVWE 661
            ::|:.||:.|..||     |||:....|:
Worm   739 EKRQEERKQLAAAK-----AAKKNTIQWD 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2162	NP_001163332.2	R3H	6..70	CDD:294210	15/64 (23%)
CG2162	NP_001163332.2	RRM_SF	519..583	CDD:302621	19/66 (29%)
F09C8.2	NP_510635.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59841
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002567
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106213
Panther	1	1.100	-	-	LDO	PTHR21678
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3424
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.970