Protein Alignment FMRFaR and Ghsr

DIOPT Version :10

• Sequence 1: NP_647758.1
• Gene: FMRFaR / 38357
• FlyBaseID: FBgn0035385
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_114464.1
• Gene: Ghsr / 84022
• RGDID: 621397
• Length: 364
• Species: Rattus norvegicus
• Alignment Length: 377
• Identity: 93/377 - (24%)
• Similarity: 173/377 - (45%)
• Gaps: 63/377 - (16%)

  Fly    85 DLGLDPDPNWTRICEDVY----NPLLENNRIEFWVCGVLINIVG--VLGILGNIISMIILSR-PQ 142
            ||..|..|....:.:::.    .|||         .||....|.  |:||.||:::|:::|| .:
  Rat    17 DLDWDASPGNDSLPDELLPLFPAPLL---------AGVTATCVALFVVGISGNLLTMLVVSRFRE 72

  Fly   143 MRSSINYLLTGLARCDTVLIITSILLFGIPSIYPYTGHFFG-YYNYVYPFISPAVFPIGMIAQTA 206
            :|::.|..|:.:|..|  |:|...:...:..::.|....|| ....::.|:|.:.        |.
  Rat    73 LRTTTNLYLSSMAFSD--LLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESC--------TY 127

  Fly   207 SIYMTFT-VTLERYVAVCHPLKARALCTYGRAKIYFIVCVCFSLAYNMPRFWEVLTVTYPEPGKD 270
            :..:|.| :::|||.|:|.||:|:.:.|.||.|:..:|....:.....|.|  ||.....|.|.|
  Rat   128 ATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIF--VLVGVEHENGTD 190

  Fly   271 VILHCVRP---SRLRRSETYIN----IYIHWCYLIVNYIIPFLTLAILNCLIYRQVKRANRERQR 328
                   |   :..|.:|..:.    ..:.|...:. :.:|...|.:|..||.|::.| .|....
  Rat   191 -------PRDTNECRATEFAVRSGLLTVMVWVSSVF-FFLPVFCLTVLYSLIGRKLWR-RRGDAA 246

  Fly   329 LSRSEKREIGLATMLLCVVIVF-FMLNFLPLVLN---ISEAF------YSTIDHKITKISNLLIT 383
            :..|.:.:....|:.:..|:|| |:|.:||..:.   .|::|      .:.|......:|.:|..
  Rat   247 VGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFY 311

  Fly   384 INSSVNFLIYIIFGEKFK-RIFLLI----FFKRRLS--RDQPDLIHYESSIS 428
            :::::|.::|.|..:|:: .:|.|:    |.:|:||  :|:......:|||:
  Rat   312 LSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSIN 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_647758.1	7tmA_FMRFamide_R-like	114..404	CDD:410630	76/312 (24%)
		TM helix 1	115..141	CDD:410630	11/28 (39%)
		TM helix 2	147..172	CDD:410630	6/24 (25%)
		TM helix 3	193..223	CDD:410630	8/30 (27%)
		TM helix 4	235..255	CDD:410630	4/19 (21%)
		TM helix 5	289..314	CDD:410630	4/28 (14%)
		TM helix 6	334..362	CDD:410630	8/31 (26%)
		TM helix 7	372..397	CDD:410630	5/24 (21%)
Ghsr	NP_114464.1	7tmA_GHSR	44..332	CDD:320259	76/308 (25%)
		TM helix 1	44..70	CDD:320259	10/25 (40%)
		TM helix 2	77..102	CDD:320259	6/26 (23%)
		TM helix 3	115..145	CDD:320259	9/37 (24%)
		TM helix 4	157..179	CDD:320259	6/23 (26%)
		TM helix 5	208..237	CDD:320259	6/29 (21%)
		TM helix 6	254..284	CDD:320259	8/29 (28%)
		TM helix 7	300..325	CDD:320259	5/24 (21%)