Protein Alignment FMRFaR and MsR1

DIOPT Version :10

• Sequence 1: NP_647758.1
• Gene: FMRFaR / 38357
• FlyBaseID: FBgn0035385
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_001261324.1
• Gene: MsR1 / 38298
• FlyBaseID: FBgn0035331
• Length: 556
• Species: Drosophila melanogaster
• Alignment Length: 569
• Identity: 119/569 - (20%)
• Similarity: 206/569 - (36%)
• Gaps: 220/569 - (38%)

  Fly   108 NNRIEFWVCGVLIN---------------IVGVLGILGNIISMIILSRPQMRSSINYLLTGLARC 157
            ||..|...||..::               :|.:||.:.|.:::|:|:|.:|||..|.:|||||..
  Fly     5 NNETEPLYCGSGMDNFHTSYKNMHGYVSLVVCILGTIANTLNIIVLTRREMRSPTNAILTGLAVA 69

  Fly   158 DTVLIITSILLFGIPSIYPYTGHFFGYYNYVYPFISP----------------AVFPIGMIAQTA 206
            |..:::..|         |||.|     :|:.....|                ::|  ..:..|.
  Fly    70 DLAVMLEYI---------PYTIH-----DYILTDSLPREEKLSYSWACFIKFHSIF--AQVLHTI 118

  Fly   207 SIYMTFTVTLERYVAVCHPLKARALC----TYGRAKIYFIVCVCFSLAYNMPRFWEVLTVT-YPE 266
            ||::|.|:.:.||:||.:|.|.|..|    |.......::|||...    .|..:.:..:| |.:
  Fly   119 SIWLTVTLAVWRYIAVGYPQKNRVWCGMRTTIITITTAYVVCVLVV----SPSLYLITAITEYVD 179

  Fly   267 P----GKDVILHCV--------------------------------------------------- 276
            .    ||  :::.:
  Fly   180 QLDMNGK--VINSIPMTQYVIDYRNELLSARTAALNATPTSAPLNETVWLNASTLLTSTTTAAPP 242

  Fly   277 RPSRLRRSETYINIY-----IH---------WCYLIVNYIIPFLTLAILNCLIYRQVKRANRERQ 327
            .||.:.|:.|...:|     :|         ..|.:|..:||.:.|.||:..:...:..|.|.|:
  Fly   243 TPSPVVRNVTVYRLYHSDLALHNASLQNATFLIYSVVIKLIPCIALTILSVRLILALLEAKRRRK 307

  Fly   328 RLS-------------------------------RSEKREIGLATMLLCVVIVFFMLNF---LPL 358
            :|:                               ..||:......|||.|:::|.:..|   :..
  Fly   308 KLTSKPATPGASNGTKSPANGKAADRPRKNSKTLEKEKQTDRTTRMLLAVLLLFLITEFPQGIMG 372

  Fly   359 VLN--ISEAFYSTIDHKITKISNLLITINSSVNFLIYIIFGEKFKRIFLLIFFKRRL-------- 413
            :||  :.:.||.....:::.:.::|..||||:||::|....::|:..|.|:|..:.|
  Fly   373 LLNAVLGDVFYLQCYLRLSDLMDILALINSSINFILYCSMSKQFRTTFTLLFRPKFLDKWLPVAQ 437

  Fly   414 -------------------SRDQPDLIHYESSISNNGDGTLNH-RSSGRFS---------RHGTQ 449
                               .|.||.::...::.:......| | ||.||.:         :.|.:
  Fly   438 DEMAAARAERSAVAPVLEKGRQQPQVVMASTTTNITQVTNLXHRRSRGRRTLLSRLLSVLKRGRR 502

  Fly   450 RSTTTTYLVATGGPGGGGCGGGG----GNNSLNN------VRLTQVSGS 488
            ||:..          |||.||||    ||:::..      |.:.:|||:
  Fly   503 RSSGE----------GGGVGGGGAPLAGNDAVEPAFQAIVVVVDKVSGA 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_647758.1	7tmA_FMRFamide_R-like	114..404	CDD:410630	87/430 (20%)
		TM helix 1	115..141	CDD:410630	8/40 (20%)
		TM helix 2	147..172	CDD:410630	8/24 (33%)
		TM helix 3	193..223	CDD:410630	10/45 (22%)
		TM helix 4	235..255	CDD:410630	3/19 (16%)
		TM helix 5	289..314	CDD:410630	9/38 (24%)
		TM helix 6	334..362	CDD:410630	9/32 (28%)
		TM helix 7	372..397	CDD:410630	8/24 (33%)
MsR1	NP_001261324.1	7tmA_FMRFamide_R-like	28..420	CDD:410630	85/413 (21%)
		TM helix 1	28..53	CDD:410630	6/24 (25%)
		TM helix 2	59..84	CDD:410630	12/38 (32%)
		TM helix 3	105..135	CDD:410630	9/31 (29%)
		TM helix 4	147..167	CDD:410630	4/23 (17%)
		TM helix 5	269..294	CDD:410630	7/24 (29%)
		TM helix 6	345..375	CDD:410630	7/29 (24%)
		TM helix 7	388..413	CDD:410630	8/24 (33%)