Protein Alignment FMRFaR and Gpr139

DIOPT Version :10

• Sequence 1: NP_647758.1
• Gene: FMRFaR / 38357
• FlyBaseID: FBgn0035385
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_001019412.1
• Gene: Gpr139 / 293545
• RGDID: 1311729
• Length: 345
• Species: Rattus norvegicus
• Alignment Length: 372
• Identity: 84/372 - (22%)
• Similarity: 152/372 - (40%)
• Gaps: 88/372 - (23%)

  Fly   116 CG------VLINIVGVLGILGNIISMIILSR---PQMRSSINYLLTGLARCDTVLIITSILLFGI 171
            ||      |..:.:..||:..||:::||||:   .:.:||.|||| .||..| :|::..|:...
  Rat    15 CGLGFVPVVYYSFLLCLGLPANILTVIILSQLVARRQKSSYNYLL-ALAAAD-ILVLFFIVFVD- 76

  Fly   172 PSIYPYTGHFFGYYNYVYPFISPAVFPIGMI------AQTASIYMTFTVTLERYVAVCHPLKARA 230
                      |...:::.....|.: |..:|      :...||::|..:|::||:|||||||...
  Rat    77 ----------FLLEDFILTMQMPPI-PDKIIEVLEFSSIHTSIWITVPLTVDRYIAVCHPLKYHT 130

  Fly   231 LCTYGRAK----IYFIVCVCFSLAYN-MPRFWEVLTVTYPEPGKDVILHCVRPSRLRRSETYINI 290
            :....|.:    ..:|.|...|:.|. .|..|                          :|.||:.
  Rat   131 VSYPARTRKVILSVYITCFLTSIPYYWWPNIW--------------------------TEDYIST 169

  Fly   291 YIH----WCYLIVNYIIPFLTLAILNCLIYRQVKRANRERQRLSRSEKREIGLATMLLCVVIVFF 351
            .:|    |.:....|::|.....|||.:|..:::|.:..|.|     ....|..|.:|..:...|
  Rat   170 SMHHVLVWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLR-----GYSTGKTTAILFTITSIF 229

  Fly   352 MLNFLPLVLNISEAFYST------IDHKITKISNLLITINSSVNFLIYIIFGEKFKRI---FLLI 407
            ...:.|.::.|....|..      :.|.:..::|:|..:|:::||.:|....::|:.:   .|..
  Rat   230 ATLWAPRIIMILYHLYGAPIQNPWLVHIMLDVANMLALLNTAINFFLYCFISKRFRTMAAATLKA 294

  Fly   408 FFKRRLSRDQPDLIHYESSISNNGDGTLNHRSSG-------RFSRHG 447
            .||   .:.||...:...:.|......::..:|.       ::.:||
  Rat   295 LFK---CQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKHG 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_647758.1	7tmA_FMRFamide_R-like	114..404	CDD:410630	75/320 (23%)
		TM helix 1	115..141	CDD:410630	11/33 (33%)
		TM helix 2	147..172	CDD:410630	9/24 (38%)
		TM helix 3	193..223	CDD:410630	10/35 (29%)
		TM helix 4	235..255	CDD:410630	5/24 (21%)
		TM helix 5	289..314	CDD:410630	7/28 (25%)
		TM helix 6	334..362	CDD:410630	5/27 (19%)
		TM helix 7	372..397	CDD:410630	7/24 (29%)
Gpr139	NP_001019412.1	7tmA_GPR139	19..288	CDD:320585	73/313 (23%)
		TM helix 1	20..46	CDD:320585	9/25 (36%)
		TM helix 2	54..79	CDD:320585	11/37 (30%)
		TM helix 3	93..123	CDD:320585	8/29 (28%)
		TM helix 4	135..155	CDD:320585	4/19 (21%)
		TM helix 5	172..197	CDD:320585	7/24 (29%)
		TM helix 6	213..245	CDD:320585	6/31 (19%)
		TM helix 7	256..281	CDD:320585	7/24 (29%)