Protein Alignment FMRFaR and Gpr142

DIOPT Version :10

• Sequence 1: NP_647758.1
• Gene: FMRFaR / 38357
• FlyBaseID: FBgn0035385
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_001333701.1
• Gene: Gpr142 / 217302
• MGIID: 2668437
• Length: 371
• Species: Mus musculus
• Alignment Length: 379
• Identity: 81/379 - (21%)
• Similarity: 145/379 - (38%)
• Gaps: 84/379 - (22%)

  Fly    60 NSQPTLQI--VLNHTEVQTDLQYPHYEDLGLDP-----------DPNWTRICEDVYNPLLENNRI 111
            ||.|...|  ...|.::...|. ||.....:.|           :|.:..:  |.:.|  |:...
Mouse     4 NSNPNSYICDAYQHADLLWSLS-PHVLTKAVQPQVTLLPTVNGSNPRYDGV--DGHWP--ESPER 63

  Fly   112 EFWVCGVL----INIVGVLGILGNIISMIILSRPQMRS---SINYLLTGLARCD----TVLIITS 165
            ...|.|::    .:::..||:..|:::.:.|:|...|:   |.:||| .|...|    .:::...
Mouse    64 SPCVAGIIPVIYYSVLLSLGLPVNVLTSVALARLAARTRKPSYHYLL-ALTASDIVTQVIIVFVG 127

  Fly   166 ILLFG------IPSIYPYTGHFFGYYNYVYPFISPAVFPIGMIAQTASIYMTFTVTLERYVAVCH 224
            .||.|      :|.....|.:...:                 .|..||:::....|::||.|:|.
Mouse   128 FLLQGAVLARQVPQAVVRTANILEF-----------------AANHASVWIAVLFTVDRYNALCR 175

  Fly   225 PLKARALCTYGRAKIYFIVCVCFSLAYNMPRFWEVLTVTYPEPGKDVILHCVRPSRLRRSETYIN 289
            ||:.||..:.||........:..:|...:|.:|.:          ||......||.:.:
Mouse   176 PLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWL----------DVWRDADPPSTMDK------ 224

  Fly   290 IYIHWCYLIVNYIIPFLTLAILN-CLIYRQVKRANRERQRLSRSEKREIGLATMLLCVVIVFFML 353
             .:.|.:.::.|.||.....:.| .:|.|..||..|..:.|       :..:|.:|..|...|.|
Mouse   225 -LLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPL-------VSKSTAILLGVTSLFAL 281

  Fly   354 NFLPLVLNISEAFYSTIDHK------ITKISNLLITINSSVNFLIYIIFGEKFK 401
            .:.|.::.:....|....|:      ...|:|:|..:|:.|||.:|....:.|:
Mouse   282 LWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFR 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_647758.1	7tmA_FMRFamide_R-like	114..404	CDD:410630	68/312 (22%)
		TM helix 1	115..141	CDD:410630	6/29 (21%)
		TM helix 2	147..172	CDD:410630	8/34 (24%)
		TM helix 3	193..223	CDD:410630	7/29 (24%)
		TM helix 4	235..255	CDD:410630	3/19 (16%)
		TM helix 5	289..314	CDD:410630	5/25 (20%)
		TM helix 6	334..362	CDD:410630	6/27 (22%)
		TM helix 7	372..397	CDD:410630	9/30 (30%)
Gpr142	NP_001333701.1	7tm_GPCRs	70..338	CDD:475119	66/308 (21%)
		TM helix 1	72..96	CDD:320257	4/23 (17%)
		TM helix 2	106..128	CDD:320257	5/22 (23%)
		TM helix 3	145..167	CDD:320257	4/38 (11%)
		TM helix 4	190..206	CDD:320257	1/15 (7%)
		TM helix 5	224..247	CDD:320257	4/29 (14%)
		TM helix 6	269..291	CDD:320257	6/21 (29%)
		TM helix 7	306..331	CDD:320257	8/24 (33%)