Protein Alignment FMRFaR and Ghsr

DIOPT Version :10

• Sequence 1: NP_647758.1
• Gene: FMRFaR / 38357
• FlyBaseID: FBgn0035385
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: XP_017175002.1
• Gene: Ghsr / 208188
• MGIID: 2441906
• Length: 427
• Species: Mus musculus
• Alignment Length: 459
• Identity: 105/459 - (22%)
• Similarity: 190/459 - (41%)
• Gaps: 93/459 - (20%)

  Fly    15 LPSPGVMP-------------PPPTDYDYGGPISDDEFLASAMATEGPTVRYDLFPQNNSQPTLQ 66
            |.||.::|             |.||....|||.....|...  ....|...::..|....:|.:.
Mouse    16 LSSPSILPAARAHSSPHAAPRPAPTLPRLGGPPQGTRFPRG--CDPKPGNMWNATPSEEPEPNVT 78

  Fly    67 IVLNHTEVQTDLQYPHYEDLGLDPDPNWTRICEDVY----NPLLENNRIEFWVCGVLINIVG--V 125
            :                 ||..|..|....:.:::.    .|||         .||....|.  |
Mouse    79 L-----------------DLDWDASPGNDSLSDELLPLFPAPLL---------AGVTATCVALFV 117

  Fly   126 LGILGNIISMIILSR-PQMRSSINYLLTGLARCDTVLIITSILLFGIPSIYPYTGHFFG-YYNYV 188
            :||.||:::|:::|| .::|::.|..|:.:|..|  |:|...:...:..::.|....|| ....:
Mouse   118 VGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSD--LLIFLCMPLDLVRLWQYRPWNFGDLLCKL 180

  Fly   189 YPFISPAVFPIGMIAQTASIYMTFT-VTLERYVAVCHPLKARALCTYGRAKIYFIVCVCFSLAYN 252
            :.|:|.:.        |.:..:|.| :::|||.|:|.||:|:.:.|.||.|:..:|....:....
Mouse   181 FQFVSESC--------TYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSA 237

  Fly   253 MPRFWEVLTVTYPEPGKDVILHCVRP---SRLRRSETYIN----IYIHWCYLIVNYIIPFLTLAI 310
            .|.|  ||.....|.|.|       |   :..|.:|..:.    ..:.|...:. :.:|...|.:
Mouse   238 GPIF--VLVGVEHENGTD-------PRDTNECRATEFAVRSGLLTVMVWVSSVF-FFLPVFCLTV 292

  Fly   311 LNCLIYRQVKRANRERQRLSRSEKREIGLATMLLCVVIVFFMLNFLPLVLN---ISEAF------ 366
            |..||.|::.|...:....|....:.......:|.||:..|:|.:||..:.   .|::|
Mouse   293 LYSLIGRKLWRRRGDAAVGSSLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLE 357

  Fly   367 YSTIDHKITKISNLLITINSSVNFLIYIIFGEKFK-RIFLLI----FFKRRLS--RDQPDLIHYE 424
            .:.|......:|.:|..:::::|.::|.|..:|:: .:|.|:    |.:|:||  :|:......:
Mouse   358 IAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTK 422

  Fly   425 SSIS 428
            |||:
Mouse   423 SSIN 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_647758.1	7tmA_FMRFamide_R-like	114..404	CDD:410630	74/311 (24%)
		TM helix 1	115..141	CDD:410630	11/28 (39%)
		TM helix 2	147..172	CDD:410630	6/24 (25%)
		TM helix 3	193..223	CDD:410630	8/30 (27%)
		TM helix 4	235..255	CDD:410630	4/19 (21%)
		TM helix 5	289..314	CDD:410630	4/28 (14%)
		TM helix 6	334..362	CDD:410630	7/30 (23%)
		TM helix 7	372..397	CDD:410630	5/24 (21%)
Ghsr	XP_017175002.1	7tmA_GHSR	107..395	CDD:320259	74/307 (24%)
		TM helix 1	107..133	CDD:320259	10/25 (40%)
		TM helix 2	140..165	CDD:320259	6/26 (23%)
		TM helix 3	178..208	CDD:320259	9/37 (24%)
		TM helix 4	220..242	CDD:320259	6/23 (26%)
		TM helix 5	271..300	CDD:320259	6/29 (21%)
		TM helix 6	317..347	CDD:320259	7/29 (24%)
		TM helix 7	363..388	CDD:320259	5/24 (21%)