DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FMRFaR and frpr-19

DIOPT Version :9

Sequence 1:	NP_001261347.1	Gene:	FMRFaR / 38357	FlyBaseID:	FBgn0035385	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_001370911.1	Gene:	frpr-19 / 189817	WormBaseID:	WBGene00021510	Length:	390	Species:	Caenorhabditis elegans

Alignment Length:	386	Identity:	113/386 - (29%)
Similarity:	187/386 - (48%)	Gaps:	57/386 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 IVLNHTEVQTDLQYPHYEDLGLDPDPNWTRICEDVYNPLLENNRIEFWVCGVLINIVGVLGILGN 131
            :::..|||      |.:|:..:....|.:..|...|:......|:   ..|::...|.:.|||.|
Worm    26 LMIGSTEV------PLFEEEDMCTPLNISCACHTDYSSYEGLERV---FLGLVAVPVIMFGILAN 81

  Fly   132 IISM-IILSRPQMRSSINYLLTGLARCDTVLIITSILLFGIPSIYPYTGHFFGYY------NYVY 189
            :.|| |...|....||||:.|..|:..||:::.::..:..:|.        ||.|      ||:.
Worm    82 VTSMRIFTHRIMSGSSINWYLAVLSASDTLILFSAFFVLSLPR--------FGEYLTWWRANYIS 138

  Fly   190 PFISPAVFPIGMIAQTASIYMTFTVTLERYVAVCHPLKARALCTYGRAKIYFIVCVCFSLAYNMP 254
            ..::|.::.:.|.|||.|::||..|::.||:.||||.|:.......|...:.|..:.||:.:|..
Worm   139 YSVTPCMYGLMMTAQTCSVFMTVGVSVHRYIGVCHPYKSVEWLPKKRVTTFIIGLLTFSVIFNTT 203

  Fly   255 RFWEV--LTVTYPEPGKDVILHCVRPSRLRRSETYINIYIHWCYLIVNYIIPFLTLAILNCLIYR 317
            ||:||  ..|.|.| ..|..:..::|:.||.::.|..|:..|.|.||.|::||..|..||.::..
Worm   204 RFFEVHISNVCYRE-NIDYYMPSLQPTALRMNDLYRQIFFGWAYTIVMYVVPFTLLIALNSMVLS 267

  Fly   318 QVKRANR---------ERQRLS-RSEKREIGLATMLLCVVIVFFMLNFLPLVLNISE------AF 366
            .|:|:.|         |.:..| ::|::|...:.||:.:|::|...|.|..|.||.|      |.
Worm   268 AVRRSRRMHMVSQCGAESEEFSKKAERKERQTSIMLISIVLLFIACNTLAFVCNIMENMGTEGAI 332

  Fly   367 YSTIDHKITKISNLLITINSSVNFLIYIIFGEKFK---RIFLLIFFKR-------RLSRDQ 417
            |.|    :...:|||:.||:|.|..:|::|..|::   |.:|...:.|       ||.:.|
Worm   333 YQT----LVTFNNLLVIINASCNICVYMLFSGKYRMLLRYYLFCDWSRQGELLIDRLEKSQ 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_001261347.1	7tm_4	122..394	CDD:304433	94/296 (32%)
FMRFaR	NP_001261347.1	7tm_1	130..393	CDD:278431	90/287 (31%)
frpr-19	NP_001370911.1	7tmA_FMRFamide_R-like	64..363	CDD:410630	98/314 (31%)
		TM helix 1	66..90	CDD:410630	9/23 (39%)
		TM helix 2	99..121	CDD:410630	5/21 (24%)
		TM helix 3	143..165	CDD:410630	9/21 (43%)
		TM helix 4	188..204	CDD:410630	4/15 (27%)
		TM helix 5	240..263	CDD:410630	10/22 (45%)
		TM helix 6	300..322	CDD:410630	7/21 (33%)
		TM helix 7	334..359	CDD:410630	9/28 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001391
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_109179
Panther	1	1.100	-	-	O	PTHR46641
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.870