DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FMRFaR and T02D1.4

DIOPT Version :9

Sequence 1:	NP_001261347.1	Gene:	FMRFaR / 38357	FlyBaseID:	FBgn0035385	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_503104.2	Gene:	T02D1.4 / 187984	WormBaseID:	WBGene00011371	Length:	446	Species:	Caenorhabditis elegans

Alignment Length:	400	Identity:	92/400 - (23%)
Similarity:	170/400 - (42%)	Gaps:	77/400 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 CEDVYNPLLENNRIEFWVCGVLINIVGVLGILGNIISMIILSRPQMRSSINYLLTGLARCDTVLI 162
            |:.:.| |.||.::..|:.|.....|.:|.:.||:::::|.:    ...|.|.:.....|..:|:
Worm    73 CDRIAN-LCENRQLYTWLVGYGFIFVFLLALFGNVVNLLIYN----SDHIKYYIAIRMLCTRLLM 132

  Fly   163 ITSILLFGIP------SIYPYTGH----FFGYYNYVYPFISPAVFPIGMIAQTASIYMTFTVTLE 217
            .:..|:..:|      |.:....|    ::.||.|...|::...|        .::::|..:|.|
Worm   133 NSLTLICMLPQALRIVSAWDSDSHINEIYWVYYPYQIYFVNLFGF--------CAMWLTVLMTAE 189

  Fly   218 RYVAVCHPLKARALCT-YGRAKIYFIVCVCFSLAYNMPRFWEVLTVTYPEPGKDVILHCVR--PS 279
            .|:.|..|..:::||| ...::.|||:.|..:|...|.:|...:|::         .||.|  |:
Worm   190 CYLHVFFPSHSKSLCTKRNLSRSYFIILVVGALLALMYKFNRSVTLS---------THCNRVIPT 245

  Fly   280 RLRRSETYINIYIHWCYLIVN----YIIP-----FLTLAILNCLIYRQ---VKRANRERQRLSRS 332
             :..||.::.|.:...:...|    .::|     |:..:||..|:.::   |.....|::.::|.
Worm   246 -IHASEDFVMICLEKIHTFANLLFAIVVPMGLLLFMAASILWKLVLKRSDFVSHFTAEKRCVTRI 309

  Fly   333 EKREIGLATM--LLCVVIVFFMLNFLPLVLN-ISEAFYSTIDHKITKISNLLITINSSVNFLIYI 394
            .....||..:  |..:.:..:...|.|.|.| .:...::|       |:..|...|.|::|.:|:
Worm   310 TLITTGLQLIAELPPIPVFLYATIFGPAVTNEPAICVWNT-------IAVFLGLCNVSLSFFVYL 367

  Fly   395 IFGEKFKRIFLLIFFKRRLSRDQP------DLIHYESSISNNGDGTLNHRSSGRFSRHGTQRST- 452
            :|.:||:.:     .|.||....|      .|:||.   :.:.|..|......|...|..|..|
Worm   368 VFSDKFREM-----VKTRLCELIPCISSPRSLVHYS---NESTDPKLRTNLLAREQVHIKQPETE 424

  Fly   453 ----TTTYLV 458
                |.|||:
Worm   425 SSVCTETYLL 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_001261347.1	7tm_4	122..394	CDD:304433	64/299 (21%)
FMRFaR	NP_001261347.1	7tm_1	130..393	CDD:278431	62/290 (21%)
T02D1.4	NP_503104.2	7tmA_FMRFamide_R-like	88..377	CDD:320109	70/322 (22%)
		TM helix 1	90..114	CDD:320109	6/27 (22%)
		TM helix 2	122..145	CDD:320109	4/22 (18%)
		TM helix 3	166..188	CDD:320109	4/29 (14%)
		TM helix 4	211..227	CDD:320109	5/15 (33%)
		TM helix 5	259..282	CDD:320109	3/22 (14%)
		TM helix 6	304..329	CDD:320109	4/24 (17%)
		TM helix 7	345..370	CDD:320109	7/31 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46641
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010