DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FMRFaR and frpr-14

DIOPT Version :9

Sequence 1:	NP_001261347.1	Gene:	FMRFaR / 38357	FlyBaseID:	FBgn0035385	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_493779.3	Gene:	frpr-14 / 187113	WormBaseID:	WBGene00019496	Length:	349	Species:	Caenorhabditis elegans

Alignment Length:	330	Identity:	98/330 - (29%)
Similarity:	159/330 - (48%)	Gaps:	33/330 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 EDLGLDPDPNWTRICEDVYNPLLENNRIEFWVCGVLINIVGVLGILGNIISMIILSRP-QMRSSI 147
            |.|..:|.|.:...|....:|  |.......|.|||:.|||::|::||::.:.....| |...|.
Worm     7 ELLDFEPPPIFCNSCLGSTDP--EYLTYNLAVSGVLLAIVGMIGLIGNMLVVKTYLHPEQAIHST 69

  Fly   148 NYLLTGLARCDTVLIITSILLFGIPSIYPYTGHFFGYYNYVYPFISPAVFPIGMIAQTASIYMTF 212
            :..|..||..|..|::|::.||.:.:   :..|.:....|:|...:|.|||:..:.||:|:|...
Worm    70 SIYLAALAFSDFFLVLTAMFLFVLEA---WRHHDYPTLAYLYVIGAPIVFPVAAVFQTSSVYFCV 131

  Fly   213 TVTLERYVAVCHPLKARAL-CTYGRAKIYFIVCVCFSLAYNMPRFWEVLTV-TYPEPGKDVILHC 275
            ...::.::.|..|...:.| ||..||||..:|.:.....||:|.|:|:..| ...|.|:|.:..|
Worm   132 AAAVDCFIMVVLPESVKQLYCTPRRAKITCVVLMLICFIYNIPHFFELEKVDCLDEDGRDSMQIC 196

  Fly   276 VRPSRLRRSETYINIYIHWCYLIVNYIIPFLTLAILN-CLIYRQVKRANRERQRLSRSEKREIGL 339
              |:.:|....|..||..:.|.....|.|...|.:|| |:::..|.:.       |.:|..|..
Worm   197 --PTDIRLDPAYYAIYYTYMYTTFLAIGPLTLLILLNICVVFTVVTKG-------SSNENGEDD- 251

  Fly   340 ATMLLCVVIVFF--------MLNFLPLVLNISEAFYSTIDHKITKISNLLITINSSVNFLIYIIF 396
             |:.|.:|:.||        |:||:.::||........:|     :||||:.:|.:.||..|:||
Worm   252 -TISLILVVFFFIFCNFTALMVNFMEIILNDPSMLVYFVD-----LSNLLVVVNGTANFFCYLIF 310

  Fly   397 GEKFK 401
            |..|:
Worm   311 GTSFR 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_001261347.1	7tm_4	122..394	CDD:304433	82/283 (29%)
FMRFaR	NP_001261347.1	7tm_1	130..393	CDD:278431	78/274 (28%)
frpr-14	NP_493779.3	7tmA_FMRFamide_R-like	36..318	CDD:320109	91/299 (30%)
		TM helix 1	37..61	CDD:320109	9/23 (39%)
		TM helix 2	70..92	CDD:320109	7/21 (33%)
		TM helix 3	113..135	CDD:320109	8/21 (38%)
		TM helix 4	159..175	CDD:320109	4/15 (27%)
		TM helix 5	209..232	CDD:320109	7/22 (32%)
		TM helix 6	252..274	CDD:320109	6/21 (29%)
		TM helix 7	286..311	CDD:320109	10/29 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001391
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.870