DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FMRFaR and frpr-8

DIOPT Version :9

Sequence 1:	NP_001261347.1	Gene:	FMRFaR / 38357	FlyBaseID:	FBgn0035385	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_509470.3	Gene:	frpr-8 / 186144	WormBaseID:	WBGene00018728	Length:	434	Species:	Caenorhabditis elegans

Alignment Length:	424	Identity:	111/424 - (26%)
Similarity:	188/424 - (44%)	Gaps:	94/424 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LQIVLNHTEVQTD-----------LQYPHYEDLGLDPDPNWTRICEDVYNPLLENNRIEFWVCGV 118
            :.::.|.|.|.||           ..||             |...|..|        |..::..:
Worm     6 ISLLNNSTLVTTDQPGFSGSTKGTCSYP-------------TNFAEVDY--------ISTYIYLL 49

  Fly   119 LINIVGVLGILGNIISMIILSRPQMRSSINYLLTGLARCDTVLIITSILLFGIPSIYPYTG---- 179
            .|..:.|||....::.:::.:|.|||||:|..|.||:..|.:|:..|.|:|.     |..|
Worm    50 AIPTICVLGAGAAVMCIVVFTRKQMRSSLNVYLAGLSVFDLILLSFSALIFS-----PLQGCVLQ 109

  Fly   180 --------HFFGYYNYVYPFISPAVFPIGMIAQTASIYMTFTVTLERYVAVCHPLKARALCTYGR 236
                    |||..       .:|...||..|||..|::....||::|::||.:||.::..||..|
Worm   110 GHGDTAVCHFFWR-------STPWTLPISNIAQCGSVWTCVAVTVDRFLAVNYPLHSKIWCTPRR 167

  Fly   237 AKIYFIVCVCFSLAYNMPRFWEVLTVTYPEPGKDVILHCVRPSRLRRSETYINIYIHWCYLIVNY 301
            |....|....||:.:..|.|:|   :|..:.|:      :|.|.||.::.|...|:.:.|||...
Worm   168 ATTILIAITVFSILFKAPMFFE---LTNDDCGR------LRTSFLRDNKYYKEYYVTFGYLIALL 223

  Fly   302 IIPFLTLAILNCLIYRQVKRANRERQRL----SRSEKREIGLATMLLCVVIVFFMLNFLPLVLNI 362
            :||:..:.|||..:.:.|.:|.:.|:.:    :..|:::.....|.:.:|:.|.:.|.:..|.|:
Worm   224 LIPWTVMIILNVFVVKAVHKAYKIRRSMQGGKNNQEEKDRRCTLMAIAMVLTFLIFNVVAAVNNL 288

  Fly   363 SEAFYSTIDHKITKISNLLITINSSVNFLIYIIFGEKFKRIFLLIFFKR--------RLSRDQPD 419
            :|..:.......:.|.||||.:||:.|.:||.:||.:|:::.:|:...|        ::.|..|
Worm   289 AETVFEVSLGFWSPIGNLLICLNSASNIVIYSLFGARFRQMCVLMLCGRQSRWMEWLKVGRYPP- 352

  Fly   420 LIHYESSISNNGDGTLNHRSSGRFSRHGTQRSTT 453
                 .|:.::.||           |.||.|.|:
Worm   353 -----QSMVSDWDG-----------RDGTTRKTS 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_001261347.1	7tm_4	122..394	CDD:304433	83/287 (29%)
FMRFaR	NP_001261347.1	7tm_1	130..393	CDD:278431	79/278 (28%)
frpr-8	NP_509470.3	7tmA_FMRFamide_R-like	45..330	CDD:320109	88/305 (29%)
		TM helix 1	47..71	CDD:320109	4/23 (17%)
		TM helix 2	79..101	CDD:320109	8/21 (38%)
		TM helix 3	125..147	CDD:320109	8/21 (38%)
		TM helix 4	170..186	CDD:320109	3/15 (20%)
		TM helix 5	212..235	CDD:320109	8/22 (36%)
		TM helix 6	263..288	CDD:320109	5/24 (21%)
		TM helix 7	301..323	CDD:320109	10/21 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001391
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46641
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.970