DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FMRFaR and frpr-5

DIOPT Version :9

Sequence 1:	NP_001261347.1	Gene:	FMRFaR / 38357	FlyBaseID:	FBgn0035385	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_001367201.1	Gene:	frpr-5 / 183856	WormBaseID:	WBGene00008342	Length:	493	Species:	Caenorhabditis elegans

Alignment Length:	388	Identity:	106/388 - (27%)
Similarity:	172/388 - (44%)	Gaps:	57/388 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 ICEDV----YNPLLENNRIEFWVCGVLI----NIVGVLGILGNIISMIILSRPQMRSSINYLLTG 153
            :|.|:    |:|..|      |...:.|    .::.|.|:|.|||::.:.:|.::::|.|..|..
Worm    33 LCSDIQRDDYSPFFE------WANYLTIILALPVLSVFGVLTNIINVFLYTRKRLQNSANTYLLF 91

  Fly   154 LARCDTVLIITSILLFGIPSIYPYTGHFF-GYYNYVYPFISPAVFPIGMIAQTASIYMTFTVTLE 217
            ||..|.::|:|.:.:|.|.|...|..... ..|..||      ..|.|.:|||.|||.|....::
Worm    92 LACSDFMVIVTGLFIFWIDSARSYIPELTQAPYTTVY------TLPFGYMAQTCSIYFTVAAAVD 150

  Fly   218 RYVAVCHPLKARALCTYGRAKIYFIVCVCFSLAYNMPRFWEV-LTVTYPEPGKDVILHCVRPSRL 281
            .:|.||...:|:..||..|||...|..|..|:.||..||.:. |...:.:..|:.::.....|..
Worm   151 CFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSLRFPQFNLRKCFNDITKEQVIEICPTSLF 215

  Fly   282 RRSETYINIYIHWCYLIVNYIIPFLTLAILNCLIYRQVKRANRERQRLSRSEKREIGLATMLLCV 346
            ....:..|||:   |:::..::||..|..:|.:|.::..:|..: :...::|.......||:: |
Worm   216 VTINSVYNIYM---YMVLMTLLPFFFLLCINAIIVKRQSKAKTD-ESAPKNEGTSDDTITMIM-V 275

  Fly   347 VIVFFMLNFLPLVLNISEAFYS---TIDHKITKISNLLITINSSVNFLIYIIFGEKFKRIFLLIF 408
            ||:|...|.|.||:|..|.|..   .:.:.::..||.|:..|||||.:||.||...::.:||:.:
Worm   276 VILFLACNTLALVVNFIENFTEPSPVLLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYRDVFLIYW 340

  Fly   409 FK------------------RRLSRDQPDLIHYESSISNNGDGT---------LNHRSSGRFS 444
            .|                  |..|..||.........|.||..:         ||......|:
Worm   341 KKLKRVLIEEYCCCCVPAGSRNYSAYQPVSTRLVIEKSQNGSSSTKLILPSLDLNRSDQASFA 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_001261347.1	7tm_4	122..394	CDD:304433	83/276 (30%)
FMRFaR	NP_001261347.1	7tm_1	130..393	CDD:278431	79/267 (30%)
frpr-5	NP_001367201.1	7tmA_FMRFamide_R-like	54..336	CDD:410630	87/292 (30%)
		TM helix 1	54..78	CDD:410630	7/23 (30%)
		TM helix 2	86..108	CDD:410630	7/21 (33%)
		TM helix 3	127..149	CDD:410630	11/27 (41%)
		TM helix 4	172..188	CDD:410630	5/15 (33%)
		TM helix 5	221..244	CDD:410630	7/25 (28%)
		TM helix 6	269..291	CDD:410630	10/22 (45%)
		TM helix 7	304..329	CDD:410630	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001391
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910