DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FMRFaR and frpr-3

DIOPT Version :9

Sequence 1:	NP_001261347.1	Gene:	FMRFaR / 38357	FlyBaseID:	FBgn0035385	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_505004.1	Gene:	frpr-3 / 182942	WormBaseID:	WBGene00016149	Length:	360	Species:	Caenorhabditis elegans

Alignment Length:	360	Identity:	103/360 - (28%)
Similarity:	169/360 - (46%)	Gaps:	42/360 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 VLINIVGVL---GILGNIISMIILSRPQMR-SSINYLLTGLARCDTVLIITSILLFG---IPSIY 175
            ||:|::.::   |||.|.||..|.:|...| .|||.||..|:..|..:.:.:|.:|.   :..:.
Worm     8 VLVNVMVLMCFGGILTNFISFYIYTRKTFRKKSINVLLAALSMSDLCVCVLAIPVFASTQLQQVI 72

  Fly   176 PYTGHFFGYYNYVYPFISPAVFPIGMIAQTASIYMTFTVTLERYVAVCHPLKARALCTYGRAKIY 240
            |.|         :...|...::|:.::.|:.|:::..::|::||:|||||......||..||.|.
Worm    73 PPT---------ITAMIMVYLYPVTIMFQSVSVWLLVSITIDRYLAVCHPFMVNTYCTRNRALIT 128

  Fly   241 FIVCVCFSLAYNMPRFWEVLTVTYP-EPGKDVILHCVRPSRLRRSETYINIYIHWCYLIVNYIIP 304
            ..|.|.||:|||:.|.|| .|:.:. .|....|...|.| :||.:..::..|.:...|:..:..|
Worm   129 VGVVVIFSVAYNLIRIWE-YTINFDVAPENRTIEDLVVP-KLRANPHFLLWYQNVATLVSQFAFP 191

  Fly   305 FLTLAILNCLIYRQVKRANRERQRLSRSEKREIGLATMLLCVVIVFFMLNFLPLVLNI-----SE 364
            ...|.:||..:.|.:..|:.:|:.|..|.|||...|.|::.||:||.:......:|||     .|
Worm   192 LTVLCVLNIQVARTIIEASEQRRELVASVKREHSTAKMMIMVVLVFLVCYIFSFILNIWEILDKE 256

  Fly   365 AFYSTIDHKITKISNLLITINSSVNFLIYIIFGEKFKRIFLLIFFKRRLSRDQPDLIHYESSISN 429
            .|...|...:..|:|:||.:||:...:.|..:..:|          |..:|..|.:..|.|....
Worm   257 TFGGDIGWFMNDINNVLIVVNSTSAIVFYYKYSTRF----------RNQARTLPGIRWYASMSKF 311

  Fly   430 N---GDGTLNHRSSGRF-----SRHGTQRSTTTTY 456
            |   .:.|.|.....|:     |..||....::::
Worm   312 NVYDTEATSNRTMVTRYKESMISIRGTSTRLSSSH 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_001261347.1	7tm_4	122..394	CDD:304433	86/284 (30%)
FMRFaR	NP_001261347.1	7tm_1	130..393	CDD:278431	83/272 (31%)
frpr-3	NP_505004.1	7tmA_FMRFamide_R-like	12..294	CDD:320109	88/302 (29%)
		TM helix 1	12..34	CDD:320109	7/21 (33%)
		TM helix 2	41..66	CDD:320109	8/24 (33%)
		TM helix 3	81..111	CDD:320109	7/29 (24%)
		TM helix 4	123..143	CDD:320109	10/19 (53%)
		TM helix 5	176..201	CDD:320109	6/24 (25%)
		TM helix 6	221..251	CDD:320109	12/29 (41%)
		TM helix 7	264..289	CDD:320109	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BKGC
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001391
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770