DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FMRFaR and frpr-1

DIOPT Version :9

Sequence 1:	NP_001261347.1	Gene:	FMRFaR / 38357	FlyBaseID:	FBgn0035385	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_509368.3	Gene:	frpr-1 / 182105	WormBaseID:	WBGene00015323	Length:	378	Species:	Caenorhabditis elegans

Alignment Length:	333	Identity:	101/333 - (30%)
Similarity:	162/333 - (48%)	Gaps:	40/333 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 ENNRIEFWVCGVLINIVGVLGILGNIISMIILSRPQMRSSINYLLTGLARCDTVLIITSILLFGI 171
            |..:....|.|:::.::|.||::||.:|....||.:|.||:|..|..||..|.|:|:|:..||.:
Worm    41 EYEQFNLVVIGLMLPLIGCLGLIGNALSAFTYSRREMISSLNVYLFALACSDIVIILTAFFLFFL 105

  Fly   172 PSIYPYTGHFFGYYNYVYPFISPAVFPIGMIAQTASIYMTFTVTLERYVAVCHPLKARA-LCT-- 233
            .::...:    .:..|.:..:||.:||:|:.|||.|:::|.....:..|.|....|.:: .|:
Worm   106 ENMRKRS----EWATYYFAVLSPVMFPLGLTAQTMSVFITVASAFDCLVLVAASEKFKSKFCSVN 166

  Fly   234 ----YGRAKIYFIVCVCFSLA---------YNMPRFWEVLTV-----TYPEPGKDVILHCVRPSR 280
                .|....:..|.||..:.         ||.|..:|:..:     .|....|||   |  |:.
Worm   167 TSILVGNFNDFKNVIVCLKIIVKIFLLGIFYNSPHMYEIYVIDCWSTMYNTASKDV---C--PTA 226

  Fly   281 LRRSETYINIYIHWCYLIVNYIIPFLTLAILNCLIYRQVKRANRERQRLSRSEKREIGLATMLLC 345
            ||.:..|:.||..:.|.||..:.|.|.|.::|..|...::|        |.|...|..:.|::|
Worm   227 LRSNVDYVRIYYVYMYTIVMAVGPVLLLIVINTAIVISMRR--------SSSPNSESDIITLVL- 282

  Fly   346 VVIVFFMLNFLPLVLNISEAFYSTIDHKITKISNLLITINSSVNFLIYIIFGEKFKRIFLLIFFK 410
            ||.:|...|.|||.:|..|..:..|:..:..:|||::.:|||.|||||..||..|:|. |..:.:
Worm   283 VVCLFISCNVLPLTVNFLELLFGIINSYLIDLSNLMVVVNSSCNFLIYYTFGSNFRRT-LRYYVR 346

  Fly   411 RRLSRDQP 418
            ..|:|..|
Worm   347 AALNRRAP 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_001261347.1	7tm_4	122..394	CDD:304433	89/292 (30%)
FMRFaR	NP_001261347.1	7tm_1	130..393	CDD:278431	85/283 (30%)
frpr-1	NP_509368.3	7tmA_FMRFamide_R-like	48..341	CDD:320109	96/311 (31%)
		TM helix 1	49..75	CDD:320109	9/25 (36%)
		TM helix 2	81..106	CDD:320109	10/24 (42%)
		TM helix 3	123..153	CDD:320109	11/29 (38%)
		TM helix 4	166..201	CDD:320109	6/34 (18%)
		TM helix 5	235..260	CDD:320109	9/24 (38%)
		TM helix 6	271..301	CDD:320109	11/30 (37%)
		TM helix 7	309..334	CDD:320109	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161138
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28852
OrthoDB	1	1.010	-	-		D1342402at2759
OrthoFinder	1	1.000	-	-		FOG0001391
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.820