DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FMRFaR and frpr-17

DIOPT Version :9

Sequence 1:	NP_001261347.1	Gene:	FMRFaR / 38357	FlyBaseID:	FBgn0035385	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_510400.2	Gene:	frpr-17 / 181541	WormBaseID:	WBGene00011765	Length:	403	Species:	Caenorhabditis elegans

Alignment Length:	387	Identity:	128/387 - (33%)
Similarity:	181/387 - (46%)	Gaps:	73/387 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 LDPD----PNWTRICEDVYNPLLENNRIEF--WVCGVLINIVGVLGILGNIISMIILSRPQMRSS 146
            :||.    .|...:|...|:...|.:.|.|  .|.|:::.||||.||:||.||..:.|||:||.|
Worm    40 IDPSSVGFQNCEPLCGICYHGSKEWDYIRFNIIVIGIILPIVGVFGIVGNAISAFVYSRPEMRCS 104

  Fly   147 INYLLTGLARCDTVLIITSILLFGIPSIYPYT---GHFFGYYNYVYPFISPAVFPIGMIAQTASI 208
            .|..|..||..||.:::|.|.||.:.:..|::   ....|.       :|..|:|:||||||.|:
Worm   105 TNLYLFSLACSDTGVVLTGIFLFSLETFRPFSLTVARISGQ-------LSAIVYPMGMIAQTCSV 162

  Fly   209 YMTFTVTLERYVAVCHPLKARALCTYGRAKIYFIVCVC---FSLAYNMPRFWE--VLTVTYPEPG 268
            |.|....::.:|.||.|.|.|.  .:.|.:....:..|   ||:.||:|.|:|  |:...:.|.|
Worm   163 YFTVCAGVDCFVQVCLPEKVRR--AFSRKETVHFLATCVVIFSVLYNVPHFFEGFVIDCYHQELG 225

  Fly   269 ---KDVILHCVRPSRLRRSETYINIYIHWCYLIVNYIIPFLTLAILNCLIYRQVKRANRERQRLS 330
               |:|   |  |:.||.:|.|.:||..:.|.|...:.|..||.|||.||
Worm   226 GMSKEV---C--PATLRYNEMYQSIYYKYMYAIFLAVGPLFTLIILNTLI--------------- 270

  Fly   331 RSEKREIGLA-----------TM-LLCVVIVFFMLNFLPLVLNISEAFYS-TIDHKITKI---SN 379
                  ||.:           || |:.||::|...|.:.||:||.|::.| |:..||..|   ||
Worm   271 ------IGFSVFGSSASNMDDTMSLILVVLLFICCNTIALVINIFESYLSETLGSKINYIVDLSN 329

  Fly   380 LLITINSSVNFLIYIIFGEKFKRIFLLIFFKRRLSRDQ-----PDLIHYESSISNNGDGTLN 436
            .|:..|||.|.:|||.:...|.......|..|:...|.     |.||..:.|.|.....||:
Worm   330 FLVVFNSSFNIIIYIKYSRPFADTLFSYFCNRKPITDNDGPGPPMLITEKPSRSKKCKETLS 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_001261347.1	7tm_4	122..394	CDD:304433	105/298 (35%)
FMRFaR	NP_001261347.1	7tm_1	130..393	CDD:278431	98/289 (34%)
frpr-17	NP_510400.2	7tmA_FMRFamide_R-like	81..354	CDD:320109	107/307 (35%)
		TM helix 2	106..128	CDD:320109	9/21 (43%)
		TM helix 3	148..170	CDD:320109	11/21 (52%)
		TM helix 4	194..210	CDD:320109	5/15 (33%)
		TM helix 5	245..268	CDD:320109	9/22 (41%)
		TM helix 6	283..308	CDD:320109	9/24 (38%)
		TM helix 7	322..347	CDD:320109	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BKGC
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001391
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.770