DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FMRFaR and frpr-13

DIOPT Version :9

Sequence 1:	NP_001261347.1	Gene:	FMRFaR / 38357	FlyBaseID:	FBgn0035385	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_505299.1	Gene:	frpr-13 / 179268	WormBaseID:	WBGene00019448	Length:	365	Species:	Caenorhabditis elegans

Alignment Length:	397	Identity:	82/397 - (20%)
Similarity:	168/397 - (42%)	Gaps:	95/397 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 TEGPTVRY-DLFPQNNSQPTLQIVLNHTEVQTDLQYPHYEDLGLDPDPNWTRI---CEDVYNPLL 106
            |..|.:.: ||:  :...|..|   |.|......|:  ||:..:....|.|::   |...::..|
Worm     2 TSEPDLHFQDLY--DKIDPPFQ---NATPFARTGQF--YENRSITDFNNTTQMIDQCPFKFSQHL 59

  Fly   107 ENNRIEFWVCGVLINIVGVLGILGNIISMIILSRP-QMRSSINYLLTGLARCDTVLIITSILLFG 170
            ....|..::.|:::.        |  ||:.:.:|| |:::::.:||..|:..:.:.::.|..:|.
Worm    60 ALATIPLFIVGLILT--------G--ISIYVYTRPYQLKTTVGFLLAWLSVFEWLFLLASFQVFS 114

  Fly   171 IPSI-----------YPYTGHFFGYYNYVYPFISPAVFPIGMIAQTASIYMTFTVTLERYVAVCH 224
            |...           ||.    ...|:.:|      :||:....:...:.::..:::::::||..
Worm   115 ISETAFFACPTTENEYPK----IKAYSEIY------IFPLTHATKYMCVCISIIISIQQWIAVFL 169

  Fly   225 PLKARALCTYGRAKIYFIVCVCFSLAYNMPRFWEVLTVTYPEPGKDVILHCVR--PSRLRRSETY 287
            |::|:.||...|.|.:.:..:..|...::|:|:        |.|    :|.:.  |.:....|.|
Worm   170 PMEAKDLCNMERTKRFLVGSLVISSILSLPKFF--------EKG----IHEINGWPWQTNAVEKY 222

  Fly   288 INIYIHWCYLIVNYIIP--------FLTLAILNCLIYRQVKRANRERQRLSRSEKREIGLATMLL 344
            ..:      .:|.|:..        |..|.|:|..|...:|.::.||.|::....|:...:.|||
Worm   223 TFL------KVVQYVEENVFSVFKIFFLLFIINVSIILLLKYSHNERIRMTSQSIRDPRTSIMLL 281

  Fly   345 CVVIVF-------FML-------NFLPLVLNISEAFYSTIDHKITKISNLLITINSSVNFLIYII 395
            .|:..:       |:|       ::||     |:.:.:..|     :||..:..:...:|..|:|
Worm   282 AVLFAYVVTHLPRFLLQYDGHWKHYLP-----SDMYIARND-----LSNYFMCCHPLFSFADYLI 336

  Fly   396 FGEKFKR 402
            |.||:::
Worm   337 FSEKYRK 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_001261347.1	7tm_4	122..394	CDD:304433	60/307 (20%)
FMRFaR	NP_001261347.1	7tm_1	130..393	CDD:278431	60/298 (20%)
frpr-13	NP_505299.1	7tmA_FMRFamide_R-like	61..345	CDD:320109	67/331 (20%)
		TM helix 1	61..83	CDD:320109	5/31 (16%)
		TM helix 2	92..114	CDD:320109	4/21 (19%)
		TM helix 3	139..161	CDD:320109	3/27 (11%)
		TM helix 4	184..200	CDD:320109	1/15 (7%)
		TM helix 5	227..250	CDD:320109	5/22 (23%)
		TM helix 6	274..299	CDD:320109	6/24 (25%)
		TM helix 7	313..338	CDD:320109	6/29 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001391
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.870