DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FMRFaR and frpr-18

DIOPT Version :9

Sequence 1:	NP_001261347.1	Gene:	FMRFaR / 38357	FlyBaseID:	FBgn0035385	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_504746.1	Gene:	frpr-18 / 179076	WormBaseID:	WBGene00020586	Length:	432	Species:	Caenorhabditis elegans

Alignment Length:	363	Identity:	106/363 - (29%)
Similarity:	185/363 - (50%)	Gaps:	40/363 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 EFWVCGVLINIVGVLGILGNIISMIILSRPQMR-SSINYLLTGLARCDTVLIITSILLFGIPSIY 175
            :...|.:|  ::.::||.||.:|.|:.|||.|| ||:|.||..|:..|..|:..||.:|.||::.
Worm     5 QLMACAIL--VIVLVGIFGNSLSFILFSRPHMRSSSVNVLLCALSFFDFSLLTLSIPIFVIPNLD 67

  Fly   176 PYTGHFFGYYNYVYPFISPAVFPIGMIAQTASIYMTFTVTLERYVAVCHPLKARALCTYGRAKIY 240
            .:... .....|: .:|...::||.::.||.|:|:...:||||:||||.||:.|..||..:::..
Worm    68 LWAND-LSLSTYM-AYILKLIYPINLMMQTCSVYIMVMITLERWVAVCRPLQVRVWCTPRKSRNA 130

  Fly   241 FIVCVCFSLAYNMPRFWE---VLTVT-------YPEPGKDVILHCVRPSRLRRSETYINIYIHWC 295
            .:|.:..:..||..||:|   |:|.:       ..:|||              ...|...|....
Worm   131 ILVIIVSAFLYNFVRFFEYRFVVTESGALYEKWLRDPGK--------------HRWYYVGYYTIL 181

  Fly   296 YLIVNYIIPFLTLAILNCLIYRQVKRANRERQRLSRSEKREIGLATMLLCVVIVFFMLNFLPLVL 360
            |::.::::||..:|..|..:...:.:.::.||.|:|.::||.....|||.|..||.:.|.||.:|
Worm   182 YIVTHFLVPFSVMAFANGHVIVAMCKLSKTRQMLTRQQQREQSTTVMLLIVTFVFAICNTLPFLL 246

  Fly   361 NISEAFYST---------IDHKITKISNLLITINSSVNFLIYIIFGEKFKRIFLLIFFKRRLSRD 416
            |:||:.:.|         :.:.:..:||||:.:||...|:||..|.||:::. |:...|......
Worm   247 NVSESIFPTLFQDESTRGLAYWLNDLSNLLVVLNSGTTFIIYFTFSEKYRQT-LVFILKNGCCAT 310

  Fly   417 QPDLIHYESSISNNGDGTLNHRSSGRFSRHGTQRSTTT 454
            ..|..:| :::|......::..:.|:..|.|::.|.::
Worm   311 VSDYNNY-TAMSRTASMRISSETGGQIQRQGSKMSNSS 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_001261347.1	7tm_4	122..394	CDD:304433	91/291 (31%)
FMRFaR	NP_001261347.1	7tm_1	130..393	CDD:278431	88/282 (31%)
frpr-18	NP_504746.1	7tmA_FMRFamide_R-like	6..299	CDD:320109	97/311 (31%)
		TM helix 1	6..32	CDD:320109	9/27 (33%)
		TM helix 2	39..64	CDD:320109	9/24 (38%)
		TM helix 3	83..113	CDD:320109	12/29 (41%)
		TM helix 4	125..145	CDD:320109	3/19 (16%)
		TM helix 5	175..200	CDD:320109	6/24 (25%)
		TM helix 6	220..250	CDD:320109	13/29 (45%)
		TM helix 7	267..292	CDD:320109	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I3100
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44567
Inparanoid	1	1.050	161	1.000	Inparanoid score	I2850
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28852
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001391
OrthoInspector	1	1.000	-	-		otm14088
orthoMCL	1	0.900	-	-		OOG6_109179
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870