DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FMRFaR and M04G7.3

DIOPT Version :9

Sequence 1:	NP_001261347.1	Gene:	FMRFaR / 38357	FlyBaseID:	FBgn0035385	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_001023318.1	Gene:	M04G7.3 / 176876	WormBaseID:	WBGene00019774	Length:	479	Species:	Caenorhabditis elegans

Alignment Length:	400	Identity:	76/400 - (19%)
Similarity:	146/400 - (36%)	Gaps:	124/400 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 IVGVLGILGNIISMIILSRPQMRSSINYLLTGLARCDTVLIITSILLFGIPS---IYPYTGHFFG 183
            :..:|.::|...::..|.|..:...:...|..|...|::|::|..|.:||.:   ::..|...:.
Worm    81 VAALLSMIGARYAIKFLCRAGLNKELTAALFALCAIDSLLLLTVFLFYGIEAMSLLFFRTNIMYD 145

  Fly   184 YYNYVYPFISPAVFPIGMIAQTASIYMTFTVTLERYVAVCHPLK-------------ARAL---- 231
            ..::.|     .:..|.....|||..:...:|..|::.|..|::             ::|:
Worm   146 KQDFTY-----NLHGIASSLTTASTALVIYITFLRFMVVVQPMRFATSMNSNHRRTGSKAVRKGS 205

  Fly   232 ---------------CTYGRAKI----------------YFIVCVCFSLAYNMPRFWEVLT---- 261
                           .|:..:.|                :.::.:.||:  |:|.|:|..|
Worm   206 AQLEDSVTNNTIFSRGTFNSSSIKRHYNIRELIRPFYIPFLLILISFSV--NIPIFFEFTTTKCF 268

  Fly   262 -------VTYPEPGKDVILHCVRPSRLRRSETYINIYIHWCYLIVNYIIPFLTLA--------IL 311
                   .|.|||            .:.||.            ...|....:||.        ||
Worm   269 NVEHNVEATNPEP------------TVFRSS------------FAKYKAVLMTLTQTIGPVSIIL 309

  Fly   312 NCLIYRQVK-----RANR---ERQRLSRS-----EKREIGLATMLLCVVIVFFMLNFLPLVLNIS 363
            ...|:.:.|     :|.|   |.|:.|||     |.:|....|:.:.:.:.|.:...:|:..::.
Worm   310 VLSIFTEYKVHVSLKARRKLFESQQRSRSVVLSEELKETVSRTVAVFIAVKFLIFRTMPIFFDVY 374

  Fly   364 EAFY-----STIDHKITKISNLLITINSSVNFLIYIIFGEK---FKRIFLLIFFKRRLSRDQPDL 420
            |..|     .|:...:.::|:..|.:|::.|.|.|  ||:|   .||:.|.:..|......:..|
Worm   375 ENLYGIDEWGTVMSIMVRVSDFGIVLNTATNSLAY--FGKKRWIEKRLRLRLMKKEEKRNAKATL 437

  Fly   421 IHYESSISNN 430
            ....||::::
Worm   438 TVQGSSLNSS 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_001261347.1	7tm_4	122..394	CDD:304433	65/359 (18%)
FMRFaR	NP_001261347.1	7tm_1	130..393	CDD:278431	64/350 (18%)
M04G7.3	NP_001023318.1	7tm_GPCRs	110..410	CDD:333717	62/332 (19%)
		TM helix 2	110..129	CDD:320095	6/18 (33%)
		TM helix 3	153..173	CDD:320095	4/19 (21%)
		TM helix 4	242..258	CDD:320095	3/17 (18%)
		TM helix 5	290..313	CDD:320095	5/22 (23%)
		TM helix 6	347..373	CDD:320095	4/25 (16%)
		TM helix 7	388..410	CDD:320095	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46641
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010