DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CPT2 and YAT2

DIOPT Version :9

Sequence 1:	NP_647756.1	Gene:	CPT2 / 38355	FlyBaseID:	FBgn0035383	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_010941.1	Gene:	YAT2 / 856745	SGDID:	S000000826	Length:	923	Species:	Saccharomyces cerevisiae

Alignment Length:	761	Identity:	168/761 - (22%)
Similarity:	283/761 - (37%)	Gaps:	205/761 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 TLYFQRSLPRLPIPLLENSCRRFLEATKPL----------LSPAEQAQTQQTVEQFRQG-IGMEL 91
            |...:..||:||:|.|.::.:|..|:.:||          |.|.:..:....:..|.:. :..:|
Yeast    16 TFKHEEELPKLPLPKLCDTLQRLKESLEPLYYADGYYQHPLDPEQIEKLSSIIRDFEENPVSEKL 80

  Fly    92 HAKLKS-HDAENKHTSYISQPWFDMYLADRAPLPLN--------------YNPLLVMKSDARPEY 141
            .:||:| ||..            |.|| |...|.:|              .||.||:..||.|..
Yeast    81 QSKLQSYHDTR------------DCYL-DELHLDINNQTSTREIQDDVLPRNPFLVLADDALPNI 132

  Fly   142 QQQVVRATNLIISSLRFWRSLQADLLEPEVYHMNAKKSDTSSYRRWMKVAPKAFATYASYAFKAF 206
             .|..|:..|:.|:.||..:|:.|||.|::...|.|
Yeast   133 -TQADRSAVLVHSAARFISALKQDLLPPDINATNGK----------------------------- 167

  Fly   207 PLDMSQYNRLFGTSRIPRIGKDE------------------------------------------ 229
            ||.|:.:..||||:|.|...:.|
Yeast   168 PLSMAPFLNLFGTTRSPVFQRGEVENFDLNKPYTASDLEDPDYSSDEDDNDEPTQKDFDDRKRKH 232

  Fly   230 -----------LVQSPDAKHILVMRRGHMYAVNVLDSSGYIESPSVILGRLRAVLKLDADREAAS 283
                       :.:.||:||||::.||..|.:.||||:..|...:..|..:...:..|:.....|
Yeast   233 EEDIFTGNGITIKRHPDSKHILIISRGQYYTLEVLDSTNKIIYTAAELTTIFNHIIKDSSGIEKS 297

  Fly   284 VPLGVLTSGQRDEWAKTRQHFVSNTKNADLLEREVDAALFCVCLDGEEDGVFNENQQEPLLKHLL 348
            ..||.|||.....|...|:.......|.  |.| :|:|||.:.||..::...|:......:..:.
Yeast   298 TALGSLTSHSFRNWKYARKRLQKRYPNE--LHR-IDSALFVLVLDESQEETTNDGDDTADISQMF 359

  Fly   349 --------------------------------AGKAQNRWFDKSISLLISADGTTAINFEHSWGD 381
                                            .|...:||:|| :.|:::||....:.::....|
Yeast   360 NRTITERDKKCTSANCKRVFYGTSIINSKGHQVGSCVSRWYDK-LQLVVTADAKATVIWDSFTCD 423

  Fly   382 GVAVLRYFNELYKDTLKQ---------------PFVS----------TETVHTPAEGDFSNVRP- 420
            |..|||:.:|:|.:::.:               |.|:          |.|:.....|. |.:.|
Yeast   424 GSVVLRFTSEIYTESVLRLARDVNAGDPQFSLWPNVTQMDPETKKLMTATISADGGGP-SEIDPK 487

  Fly   421 -----INFEIDDATKSAVSEAYNKNASIVDNLDMNVLKYPHINKPTCKQYGLSPDSIIQLSFQLA 480
                 |::...:...:.|..:..|.|.::...|:.....| :.:.:.::.|:.|||::|::.|:|
Yeast   488 LVVNKIDWSFSNILNTHVHLSETKLADLISKYDIVRASIP-LGRRSAQRLGVKPDSMVQVALQIA 551

  Fly   481 YRQAYSGYVGSYESCSTSAFRHGRTETMRPCTNATRDFCEAILQPERSKPSAGELRAMIDNCSKV 545
            :...|...|...|..||..|::.|:..:...:.|..:.|:..:  ..|.....:|...|..| :.
Yeast   552 HYALYGRMVFGLEPVSTRGFKNSRSSFINIQSQALLELCQLFI--SSSIDGTDKLDKFIQTC-ET 613

  Fly   546 HGQLTKEAAMGQGFDRHLFALR-----------HTAQKEGIPIPDLYETEAYKRINNNIISTSTL 599
            |..:.|.|..|.|:::|..||:           |.:..|.....||:|.......:...:..:..
Yeast   614 HNNMVKHAKSGVGYEKHFNALKYLFKFHDHFGIHLSGDESSAAKDLFENPLVLPFSQPELIVANC 678

  Fly   600 GSDALLAGSFGPVVKNGFGIGYSIQNDFAGAIVTTYKNQADGKVFI 645
            |:.|.......|.|.:||||||.|::|.....||:...|.|..:|:
Yeast   679 GNAATTTFGITPAVPHGFGIGYIIKDDQVDLTVTSQFRQGDRLMFM 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPT2	NP_647756.1	Carn_acyltransf	45..655	CDD:279140	167/754 (22%)
YAT2	NP_010941.1	Carn_acyltransf	23..733	CDD:395612	167/754 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346193
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3719
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1588
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.690