DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CPT2 and Cpt1c

DIOPT Version :9

Sequence 1:	NP_647756.1	Gene:	CPT2 / 38355	FlyBaseID:	FBgn0035383	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001344599.1	Gene:	Cpt1c / 78070	MGIID:	2446526	Length:	799	Species:	Mus musculus

Alignment Length:	687	Identity:	182/687 - (26%)
Similarity:	287/687 - (41%)	Gaps:	120/687 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GQHYQYLQCSKLPTLY-FQRSLPRLPIPLLENSCRRFLEATKPLLSPAEQAQTQQTVEQFRQGIG 88
            |:|         |.|: |||:|||.|:|..:.:.|::||:.:|:|......:.......|
Mouse   159 GRH---------PRLFSFQRALPRQPVPSAQETVRKYLESVRPVLGDDAFDRATALANDF----- 209

  Fly    89 MELHA-------KLKSHDAENKHTSYISQPWFD-MYLADRAPLPLNYNPLLVMKSD---ARPEYQ 142
            :.|||       :|||....|    |:|..|.: :||..|..|   .|....|..|   ..|. .
Mouse   210 LRLHAPRLQLYLQLKSWCTSN----YVSDWWEEFVYLRSRGSL---INSTYYMMQDFLYVTPT-P 266

  Fly   143 QQVVRATNLIISSLRFWRSLQADLLEPEVYHMNAKKSDTSSYRRWMKVAPKAFATYASYAFKAFP 207
            .|..||.|.:.:.|.:...|....:.|.:. |..:                             |
Mouse   267 LQAARAGNAVHTLLLYRHLLNRQEISPTLL-MGMR-----------------------------P 301

  Fly   208 LDMSQYNRLFGTSRIPRIGKDELVQSPDAKHILVMRRGHMYAVNVLDSSGYIESPSVILGRLRAV 272
            |..:||.|:|.|:|||.:.||.|....|::|:.|..||..:.|.....:|.: ||..:..:.:.:
Mouse   302 LCSAQYERMFNTTRIPGVEKDHLRHLQDSRHVAVFHRGRFFRVGTHSPNGLL-SPRALEQQFQDI 365

  Fly   273 LKLDADREAASVP----LGVLTSGQRDEWAKTRQHFVSNTKNADLLEREVDAALFCVCLDGEEDG 333
            |    |..:.:.|    |..||:..|..||:.|:..  .|..|..|| .|:.|.|.|.||.|..|
Mouse   366 L----DDPSPACPLEEHLAALTAAPRSMWAQVRESV--KTHAATALE-AVEGAAFFVSLDSEPAG 423

  Fly   334 VFNENQQEPLLKH---LLAGKAQNRWFDKSISLLISADGTTAINFEHSWGDGVAVLRYFNELYKD 395
            :..|:....|..:   ||||:..:||||||.:|::.::|...::.||||.|    ......|::.
Mouse   424 LTREDPAASLDAYAHALLAGRGHDRWFDKSFTLIVFSNGKLGLSVEHSWAD----CPVSGHLWEF 484

  Fly   396 TLKQPFVSTETV--------HTPAEGDFSNVRP--INFEIDDATKSAVSEAYNKNASIVDNLDMN 450
            ||     :||..        |.....|.:..:|  :.:::.:..:.::|.|.....::..|:|.:
Mouse   485 TL-----ATECFQLGYATDGHCKGHPDPTLPQPQRLQWDLPEQIQPSISLALRGAKTLSGNIDCH 544

  Fly   451 VLKYPHINKPTCKQYGLSPDSIIQLSFQLAYRQAYSGYVGSYESCSTSAFRHGRTETMRPCTNAT 515
            |..:.|..|...|...:|.||.|||..|||:.:....:..:|||..|..|..|||||:|.||...
Mouse   545 VFPFSHFGKSFIKCCHVSSDSFIQLVLQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREA 609

  Fly   516 RDFCEAILQPERSKPSAGELRAMIDNCSKVHGQLTKEAAMGQGFDRHLFALRHTAQKEGIPIPDL 580
            ..|..|:...|..:......|..:|.    |..|.|.|..|||.|||||||...::...:..|.|
Mouse   610 CQFVRAMDNKETDQHCLALFRVAVDK----HQALLKAAMSGQGIDRHLFALYIMSRLLHMQSPFL 670

  Fly   581 YETEAYKRI---------NNNIISTSTLGSDALLAGSFGPVVKNGFGIGYSIQNDFAGAIVTTYK 636
            .:.::.:.:         ..::|............|.|||...:|:||.|....:.|   :|.:.
Mouse   671 TQVQSQQWLLSTSQVPVQQTHLIDVHNYPDYVSSGGGFGPAHDHGYGISYIFMGENA---ITFHI 732

  Fly   637 NQADGKVFIDS------LESAFDKICAVIQQSSSSKK 667
            :........||      :|:|...:.::.:.....|:
Mouse   733 SSKKSSTETDSHRLGQHIENALLDVASLFRVGQHFKR 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPT2	NP_647756.1	Carn_acyltransf	45..655	CDD:279140	174/652 (27%)
Cpt1c	NP_001344599.1	CPT_N	1..46	CDD:318644
		Carn_acyltransf	171..754	CDD:307070	173/649 (27%)
		Coenzyme A binding. /evidence=ECO:0000250	552..564		3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920