DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CPT2 and Cpt2

DIOPT Version :9

Sequence 1:	NP_647756.1	Gene:	CPT2 / 38355	FlyBaseID:	FBgn0035383	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_037062.1	Gene:	Cpt2 / 25413	RGDID:	2398	Length:	658	Species:	Rattus norvegicus

Alignment Length:	630	Identity:	282/630 - (44%)
Similarity:	412/630 - (65%)	Gaps:	16/630 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 YLQCSKLPTLYFQRSLPRLPIPLLENSCRRFLEATKPLLSPAEQAQTQQTVEQFRQGIGMELHAK 94
            |||.|.:||:::|.||||||||.||::.:|:|.|.||||..::..:|:...:.|..|:|.||||.
  Rat    34 YLQHSIVPTMHYQDSLPRLPIPKLEDTMKRYLNAQKPLLDDSQFRRTEALCKNFETGVGKELHAH 98

  Fly    95 LKSHDAENKHTSYISQPWFDMYLADRAPLPLNYNPLLVMKSDARPEYQQQVVRATNLIISSLRFW 159
            |.:.|.:||||||||.|||||||..|..:.||:||.:....|.:.||..|:.|||||.:|::||.
  Rat    99 LLAQDKQNKHTSYISGPWFDMYLTARDSIVLNFNPFMAFNPDPKSEYNDQLTRATNLTVSAVRFL 163

  Fly   160 RSLQADLLEPEVYHMNAKKSDTSSYRRWMKVAPKAFATYASYAFKAFPLDMSQYNRLFGTSRIPR 224
            ::|||.||||||:|:|..||||.:::|.::..|.:.:.|.:|...|:|||||||.|||.::||||
  Rat   164 KTLQAGLLEPEVFHLNPSKSDTDAFKRLIRFVPPSLSWYGAYLVNAYPLDMSQYFRLFNSTRIPR 228

  Fly   225 IGKDELVQSPDAKHILVMRRGHMYAVNVLDSSGYIESPSVILGRLRAVLKLDADREAASVPLGVL 289
            ..:|||.....|:|:||:|:||.|..:|||..|.|.:|..|...|:.:|. |:. .....|:..|
  Rat   229 PNRDELFTDTKARHLLVLRKGHFYVFDVLDQDGNIVNPLEIQAHLKYILS-DSS-PVPEFPVAYL 291

  Fly   290 TSGQRDEWAKTRQHFVSNTKNADLLEREVDAALFCVCLDGEEDGVFNENQQEPLLKHLLAGKAQN 354
            ||..||.||:.||..:.:.....|  ::||:|:||:|||.     |.......|...:|.|...|
  Rat   292 TSENRDVWAELRQKLIFDGNEETL--KKVDSAVFCLCLDD-----FPMKDLIHLSHTMLHGDGTN 349

  Fly   355 RWFDKSISLLISADGTTAINFEHSWGDGVAVLRYFNELYKDTLKQPFVSTETVHTPAEGDFSNVR 419
            ||||||.:|:::.|||.|::|||||||||||||:|||:::|:.:.|.::.:: ...|....::|.
  Rat   350 RWFDKSFNLIVAEDGTAAVHFEHSWGDGVAVLRFFNEVFRDSTQTPAITPQS-QPAATNSSASVE 413

  Fly   420 PINFEIDDATKSAVSEAYNKNASIVDNLDMNVLKYPHINKPTCKQYGLSPDSIIQLSFQLAYRQA 484
            .::|.:..|.|:.::.|..|..:.|..|.::.:::....|...|:..||||::.||:||:|:.:.
  Rat   414 TLSFNLSGALKAGITAAKEKFDTTVKTLSIDSIQFQRGGKEFLKKKQLSPDAVAQLAFQMAFLRQ 478

  Fly   485 YSGYVGSYESCSTSAFRHGRTETMRPCTNATRDFCEAILQPERSKPSAGELRAMIDNCSKVHGQL 549
            |...|.:||||||:||:||||||:||.:..|:...||.:: :.||.|.|||:.|:..|||.||||
  Rat   479 YGQTVATYESCSTAAFKHGRTETIRPASIFTKRCSEAFVR-DPSKHSVGELQHMMAECSKYHGQL 542

  Fly   550 TKEAAMGQGFDRHLFALRHTAQKEGIPIPDLYETEAYKRINNNIISTSTLGSDALLAGSFGPVVK 614
            ||||||||||||||:|||:.|...|:.:|:||...||:::|:||:|||||.|.|:..|.|.|||.
  Rat   543 TKEAAMGQGFDRHLYALRYLATARGLNLPELYLDPAYQQMNHNILSTSTLNSPAVSLGGFAPVVP 607

  Fly   615 NGFGIGYSIQNDFAGAIVTTYKNQADGKVFI----DSLESAFDKI 655
            :||||.|::.:|:.|..|::|..: :.:.|:    ..||..||.:
  Rat   608 DGFGIAYAVHDDWIGCNVSSYSGR-NAREFLHCVQKCLEDIFDAL 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPT2	NP_647756.1	Carn_acyltransf	45..655	CDD:279140	274/613 (45%)
Cpt2	NP_037062.1	Carn_acyltransf	49..648	CDD:279140	272/610 (45%)
Cpt2	NP_037062.1	Coenzyme A binding. /evidence=ECO:0000250	452..464		4/11 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353004
Domainoid	1	1.000	532	1.000	Domainoid score	I270
eggNOG	1	0.900	-	-		E1_KOG3719
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H77
Inparanoid	1	1.050	547	1.000	Inparanoid score	I1105
OMA	1	1.010	-	-		QHG56597
OrthoDB	1	1.010	-	-		D167256at33208
OrthoFinder	1	1.000	-	-		FOG0006491
OrthoInspector	1	1.000	-	-		oto98633
orthoMCL	1	0.900	-	-		OOG6_104379
Panther	1	1.100	-	-	LDO	PTHR22589
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4735
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770