Protein Alignment CPT2 and CRAT

DIOPT Version :10

• Sequence 1: NP_647756.1
• Gene: CPT2 / 38355
• FlyBaseID: FBgn0035383
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: NP_001333475.2
• Gene: CRAT / 1384
• HGNCID: 2342
• Length: 627
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 164/641 - (25%)
• Similarity: 293/641 - (45%)
• Gaps: 63/641 - (9%)

  Fly    42 QRSLPRLPIPLLENSCRRFLEATKPLLSPAEQAQTQQTVEQFRQ--GIGMELHAKLKSHDAENKH 104
            |.:|||||:|.|:.|...:|:|.:|::|..|.|.|:|.|::|:.  |:|..|...|:..  ..|.
Human    33 QDALPRLPVPPLQQSLDHYLKALQPIVSEEEWAHTKQLVDEFQASGGVGERLQKGLERR--ARKT 95

  Fly   105 TSYISQPWF-DMYLADRAPLPLNYNPLLVMKSDARPEYQQQVVRATNLIISSLRFWRSLQADLLE 168
            .:::|:.|. ..||..|.|:.:..:|.:::......:.|.|:..|..||...|.|...:..:.|.
Human    96 ENWLSEWWLKTAYLQYRQPVVIYSSPGVMLPKQDFVDLQGQLRFAAKLIEGVLDFKVMIDNETLP 160

  Fly   169 PEVYHMNAKKSDTSSYRRWMKVAPKAFATYASYAFKAFPLDMSQYNRLFGTSRIPRIGKDELVQS 233
            .|  ::..|                             ||.|:||.::..:.|:|...:|.:...
Human   161 VE--YLGGK-----------------------------PLCMNQYYQILSSCRVPGPKQDTVSNF 194

  Fly   234 PDAK----HILVMRRGHMYAVNVLDSSGYIESPSVILGRLRAV--LKLDADREAASVPLGVLTSG 292
            ...|    ||.|:.....:.::|..|.|...:...|..:|..:  ..|..::|    |:|:|||.
Human   195 SKTKKPPTHITVVHNYQFFELDVYHSDGTPLTADQIFVQLEKIWNSSLQTNKE----PVGILTSN 255

  Fly   293 QRDEWAKTRQHFVSNTKNADLLEREVDAALFCVCLDGEEDGVFNENQQEPLLKHLLAG-----KA 352
            .|:.|||.....:.:..|.|.: |.:..::|.||||.....|..:..:..:...:|.|     .:
Human   256 HRNSWAKAYNTLIKDKVNRDSV-RSIQKSIFTVCLDATMPRVSEDVYRSHVAGQMLHGGGSRLNS 319

  Fly   353 QNRWFDKSISLLISADGTTAINFEHSWGDGVAVLRYFNELYKDTLKQPFVSTETVHTPAEGDFSN 417
            .||||||::..:::.||:..:.:||:..:|..::...:.:.:.|.|...|.:..|..|..
Human   320 GNRWFDKTLQFIVAEDGSCGLVYEHAAAEGPPIVTLLDYVIEYTKKPELVRSPLVPLPMP----- 379

  Fly   418 VRPINFEIDDATKSAVSEAYNKNASIVDNLDMNVLKYPHINKPTCKQYGLSPDSIIQLSFQLAYR 482
             :.:.|.|....||.:.:|....:.::.:||:.|:.:.|..|...|...||||:.||::.||||.
Human   380 -KKLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKDFPKSEKLSPDAFIQMALQLAYY 443

  Fly   483 QAYSGYVGSYESCSTSAFRHGRTETMRPCTNATRDFCEAILQPERSKPSAGELRAMIDNCSKVHG 547
            :.|.....:|||.|...|..|||:|:|..:..:..|.:|:   :.|..:..:...::....:.|.
Human   444 RIYGQACATYESASLRMFHLGRTDTIRSASMDSLTFVKAM---DDSSVTEHQKVELLRKAVQAHR 505

  Fly   548 QLTKEAAMGQGFDRHLFALRHTAQKEGIPIPDLYETEAYKRINNNIISTSTLGSDALLAGSFGPV 612
            ..|..|..|:.|||||..|:..|.::.:.:||::...:|....:..:|||.:.:.......||||
Human   506 GYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFHLSTSQVPAKTDCVMFFGPV 570

  Fly   613 VKNGFGIGYSIQNDFAGAIVTTYKNQADGKV--FIDSLESAFDKICAVIQQSSSSK 666
            |.:|:|:.|:.........::.|.:.|:...  ....||.|...:.|::|....:|
Human   571 VPDGYGVCYNPMEAHINFSLSAYNSCAETNAARLAHYLEKALLDMRALLQSHPRAK 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPT2	NP_647756.1	Carn_acyltransf	48..650	CDD:459926	155/617 (25%)
CRAT	NP_001333475.2	Carn_acyltransf	39..610	CDD:459926	155/617 (25%)