Protein Alignment CPT2 and CPT1B

DIOPT Version :10

• Sequence 1: NP_647756.1
• Gene: CPT2 / 38355
• FlyBaseID: FBgn0035383
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: NP_004368.1
• Gene: CPT1B / 1375
• HGNCID: 2329
• Length: 772
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 169/624 - (27%)
• Similarity: 291/624 - (46%)
• Gaps: 80/624 - (12%)

  Fly    31 LQCSKLPTLY-FQRSLPRLPIPLLENSCRRFLEATKPLLSPAEQAQTQQTVEQFRQGIG--MELH 92
            |..|:.|.|| ||.|||:||:|.:..:.:|:||:.:|||...|..:.:...::|:....  ::.:
Human   158 LLSSRHPMLYSFQTSLPKLPVPRVSATIQRYLESVRPLLDDEEYYRMELLAKEFQDKTAPRLQKY 222

  Fly    93 AKLKSHDAENKHTSYISQPWFD-MYLADRAPLPLNYN-----PLLVMKSDARPEYQQQVVRATNL 151
            ..|||..|.|    |:|..|.: :||..|:||.:|.|     .:|:..:|.      |..|..|:
Human   223 LVLKSWWASN----YVSDWWEEYIYLRGRSPLMVNSNYYVMDLVLIKNTDV------QAARLGNI 277

  Fly   152 IISSLRFWRSLQADLLEPEVYHMNAKKSDTSSYRRWMKVAPKAFATYASYAFKAFPLDMSQYNRL 216
            |.:.:.:.|.|..:.::|.:                              |....|:...|..|:
Human   278 IHAMIMYRRKLDREEIKPVM------------------------------ALGIVPMCSYQMERM 312

  Fly   217 FGTSRIPRIGKDELVQSPDAKHILVMRRGHMYAVNVLDSSGYIESPSVILGRLRAVLKLDADREA 281
            |.|:|||....|.|....|::|:.|..:|..:.:.:.:.:..:: |..:..:.:.:|...:..:.
Human   313 FNTTRIPGKDTDVLQHLSDSRHVAVYHKGRFFKLWLYEGARLLK-PQDLEMQFQRILDDPSPPQP 376

  Fly   282 ASVPLGVLTSGQRDEWAKTRQHFVSNTKNADLLEREVDAALFCVCLDGEEDGVFNENQQEPLL-- 344
            ....|..||:|.|.|||:.||.|.|:.||...|| .::.|.|.|.||.|......|::....|
Human   377 GEEKLAALTAGGRVEWAQARQAFFSSGKNKAALE-AIERAAFFVALDEESYSYDPEDEASLSLYG 440

  Fly   345 KHLLAGKAQNRWFDKSISLLISADGTTAINFEHSWGDGVAVLRYFNELYKDTLKQPFVSTETVHT 409
            |.||.|...|||||||.:|:...:|...:|.||:|.| ..::.:..|....|.......|||.|.
Human   441 KALLHGNCYNRWFDKSFTLISFKNGQLGLNAEHAWAD-APIIGHLWEFVLGTDSFHLGYTETGHC 504

  Fly   410 PAEGDFSNVRP--INFEIDDATKSAVSEAYNKNASIVDNLDMNVLKYPHINKPTCKQYGLSPDSI 472
            ..:.:.:...|  :.::|....::.:..:|....::.|::::...::....|...|:...|||:.
Human   505 LGKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAF 569

  Fly   473 IQLSFQLAYRQAYSGYVGSYESCSTSAFRHGRTETMRPCTNATRDFCEAILQPERSKPSAGELRA 537
            :|::.|||:.:....:..:||:..|..||.|||||:|.||:.:..|.:|:::...:|   .:||.
Human   570 VQIALQLAHFRDRGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVQAMMEGSHTK---ADLRD 631

  Fly   538 MIDNCSKVHGQLTKEAAMGQGFDRHLFALRHTAQKEGIPIPDLYE--TEAYKRINNNIISTSTLG 600
            :....:|.|..:.:.|..|.|.|||||.|...::..|:..|.|.|  :|.::      :|||.:.
Human   632 LFQKAAKKHQNMYRLAMTGAGIDRHLFCLYLVSKYLGVSSPFLAEVLSEPWR------LSTSQIP 690

  Fly   601 SDAL-------------LAGSFGPVVKNGFGIGYSIQND 626
            ...:             ..|.||||..:|:|:.|.|..:
Human   691 QSQIRMFDPEQHPNHLGAGGGFGPVADDGYGVSYMIAGE 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPT2	NP_647756.1	Carn_acyltransf	48..650	CDD:459926	159/606 (26%)
CPT1B	NP_004368.1	CPT_N	1..47	CDD:465132
		Carn_acyltransf	176..756	CDD:459926	159/606 (26%)